The enteric toxicity of gluten enhances graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

abstract：:A holistic-organismic approach is suggested as foundation for intensified, systematic inquiry into relationships among adult attachment styles and various dimensions of physical and mental health. Exploratory findings of differences in stamina associated with adult attachment style are noted. The extent to which attac...

journal_title：Medical hypotheses

authors： Pellegrini RJ,Hicks RA,Camagna-Foley TF,Donato M

更新日期：2003-07-01 00:00:00

abstract：:Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu...

journal_title：Medical hypotheses

authors： Greenspan HC

更新日期：1993-02-01 00:00:00

abstract：:Optic neuropathy is an invaliding pathology with diverse clinical manifestation and varying causes. Current understanding of etiopathological aspects of optical neuropathy does not provide an effective treatment protocol. In this article we discuss existing treatment methods, and their effectiveness, evaluated dependi...

journal_title：Medical hypotheses

authors： Shkarubo AN,Nikolenko VN,Velichko AY,Sinelnikov MY

更新日期：2020-10-01 00:00:00

abstract：:The disturbances of the 11p15.5 chromosomal region are associated with Beckwith-Wiedemann syndrome, Russell-Silver syndrome, Wilms tumor, IMAGe syndrome, and idiopathic hemihyperplasia. The aim of this research was to examine the hypothesis that 11p15.5 initially became unstable in the European population about 200 ye...

journal_title：Medical hypotheses

authors： Shterenshis M,Roitblat Y,Ilani J,Lumbroso J,Padilla-Raygoza N

更新日期：2018-12-01 00:00:00

abstract：:Most cancer cells differ from normal cells in that they show higher beta-glucuronidase activity and lower pH of their cytoplasm. Anti-cancer drugs can be designed which take advantage of these gradients to deliver maximal toxicity to tumors and minimal toxicity to normal tissue. Many design criteria are suggested here...

journal_title：Medical hypotheses

authors： Rubin DM,Rubin EJ

更新日期：1980-01-01 00:00:00

abstract：:The paper based on the hypothesis that mechanical impulses cause the transmission of excitement in the peripheral and central nervous system. Possible connections between changes in the tubular neuronal network and the morphological findings of Alzheimer's disease are presented. Additionally, changes in the viscosity ...

journal_title：Medical hypotheses

authors： Barz H,Barz U

更新日期：2014-05-01 00:00:00

abstract：:Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development o...

journal_title：Medical hypotheses

authors： Mikolasevic I,Racki S,Lukenda V,Pavletic-Persic M,Milic S,Orlic L

更新日期：2014-01-01 00:00:00

abstract：:There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compare...

journal_title：Medical hypotheses

authors： Dahlen HG,Kennedy HP,Anderson CM,Bell AF,Clark A,Foureur M,Ohm JE,Shearman AM,Taylor JY,Wright ML,Downe S

更新日期：2013-05-01 00:00:00

abstract：:The Davson-Danielli model of the cell membrane accounted for nearly all the space within it by suggesting that it was composed of structural proteins and lipids; this would leave virtually no space for the large number of enzymes, carriers, antigens, antibodies, and receptors for hormones, transmitters, drugs and toxi...

journal_title：Medical hypotheses

authors： Hillman H

更新日期：1988-07-01 00:00:00

abstract：:Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

journal_title：Medical hypotheses

authors： Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

更新日期：2013-01-01 00:00:00

abstract：:Styrene is one of the most important plastic monomers worldwide. Styrene-7,8-oxide (SO), the major in-vivo metabolite of styrene, is classified as probably carcinogenic to humans and carcinogenic in rodents. Biological monitoring of exposure to styrene is usually carried out by determination of mandelic acid and pheny...

journal_title：Medical hypotheses

authors： Marczynski B,Peel M,Baur X

更新日期：2000-04-01 00:00:00

abstract：:We develop here the hypothesis that polycystic kidneys (PCK) may maintain, to a certain extent, the ability to perform endocrine functions. We know that patients with adult polycystic kidney disease (APCKD) produce more erythropoietin and maintain a higher hematocrit than patients with other primary diseases of the ki...

journal_title：Medical hypotheses

authors： Rotellar C,Gelfand MC

更新日期：1989-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary tumor of liver and its incidence continues to increase worldwide. HCC is a disease with multifactorial causes and genetic variability has been discussed as a risk factor for its development. Liver is a hormone-sensitive organ and therefore is influenced by gona...

journal_title：Medical hypotheses

authors： Baldissera VD,Alves AF,Almeida S,Porawski M,Giovenardi M

更新日期：2016-01-01 00:00:00

abstract：:In a previous paper, I have proposed that the deficiency of an endogenous caffeine-like substance is the underlying pathogenic mechanism in schizophrenia (1). In the present paper, my new concept is used to explain many of the clinical, biochemical, radiologic and pharmacologic facts about schizophrenia. ...

journal_title：Medical hypotheses

authors： Missak SS

更新日期：1991-10-01 00:00:00

abstract：:In the present study, we used the potential of bioinformatics and computational analysis to predict the existence and biological relevance of zinc finger (ZF) motifs in heamagglutinin (HA) protein of Avian Influenza (AI) virus. Sequence data of Avian Influenza (AI) viruses were retrieved from accessible databases (Gen...

journal_title：Medical hypotheses

authors： Muraina IA,Meseko CA,Fasina FO

更新日期：2020-11-01 00:00:00

abstract：:The efficiency of anti-tumour drug strongly depends on its dose. Higher drug doses and exposure times usually result in better treatment. It is why the implementation of high-dose treatment is always attractive. However, most of the drug delivery techniques meet essential limitations. In isolated regional perfusion a ...

journal_title：Medical hypotheses

authors： Rukhlenko OS,Guria GT,Vorobiev AI

更新日期：2017-07-01 00:00:00

abstract：:Vulvodynia (vulvar pain syndrome) is a chronic multifactorial disease affecting almost 13 million women in the USA and can lead to morbidity and a reduced quality of life. We hypothesize that an initial microbiological insult in the vagina causes modifications in the biological vaginal milieu and/or an alteration on t...

journal_title：Medical hypotheses

authors： Ventolini G,Gygax SE,Adelson ME,Cool DR

更新日期：2013-08-01 00:00:00

abstract：:The structural rearrangement of human sheathed capillaries in congestive splenomegaly has been considered. In abnormal spleens the external diameter and wall thickness were decreased, while the internal diameter was increased. Moreover, the total length and the absolute number of sheathed capillaries were increased, t...

journal_title：Medical hypotheses

authors： Pallotti C,Pettazzoni P,Slawomirski MR

更新日期：1995-05-01 00:00:00

abstract：:An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

journal_title：Medical hypotheses

authors： Lin YP,Cheng TJ

更新日期：2002-08-01 00:00:00

abstract：:Over-degradation of extracellular components by matrix metalloproteinases (MMPs) has been implicated as an important characteristic during the pathological evolution of the abdominal aortic aneurysm (AAA) and cerebral aneurysm (CA), which contribute to progressive dilation of vascular wall. However, mRNA and protein e...

journal_title：Medical hypotheses

authors： Zhou X,Ji WJ,Tu Y,Yao M,Li YM

更新日期：2007-01-01 00:00:00

abstract：:Depression is often associated with insulin resistance, owing to cortisol overproduction; conversely, many studies suggest that diabetics are at increased risk for depression. Recent evidence indicates that insulin is transported through the blood-brain barrier and influences brain function via widely distributed insu...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：1994-10-01 00:00:00

abstract：:Fissured tongue (FT) is a condition frequently seen in the general population. Clinically, FT is characterized by grooves that vary in depth and are noted along the dorsal and/or dorsolateral aspects of the tongue. Furthermore, FT presents many enlarged, smooth filiform papillae and subepithelial inflammatory infiltra...

journal_title：Medical hypotheses

authors： Järvinen J,Mikkonen JJ,Kullaa AM

更新日期：2014-06-01 00:00:00

abstract：:Human endometrium is a highly regenerative tissue and contains a low number of cells which have high replicative ability and differentiation efficiency. This has been identified by many scientists. When the fresh growth of tissue and blood vessels is shed during each menstrual cycle, some cells with regenerative capab...

journal_title：Medical hypotheses

authors： Zhang MJ,Liu B,Xia W,Sun ZY,Lu KH

更新日期：2009-03-01 00:00:00

abstract：:Pelvis is a functional shell-like unit consisting of the pelvic floor and perineum. The patients, who underwent a radical operation of the pelvis due to an oncological disease, often develop pelvic disorders. These disorders do not depend on the type of surgery or any presence of postoperative treatment (radio- and ch...

journal_title：Medical hypotheses

authors： Vannelli A,Battaglia L,Poiasina E,Leo E

更新日期：2009-03-01 00:00:00

abstract：:Logic, a fundamental component of research in the exact sciences is often not applied in prominent fields of medical research. Investigation into the aetiopathogenesis of headache, vertigo, and fatigue--acknowledged as the commonest and amongst the most prominent and debilitating of symptoms known to mankind--may be s...

journal_title：Medical hypotheses

authors： Eidelman D

更新日期：1990-04-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The hallmark pathologic feature of PD is dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons. Current treatments for PD mainly address the dopaminergic features of the disease; howe...

journal_title：Medical hypotheses

authors： Tsai SJ

更新日期：2007-01-01 00:00:00

abstract：:A mechanism of action for Panax ginseng (PG) and Eleutherococcus senticosus (ES) is proposed which explains how they could produce the paradoxical effect of sometimes increasing and sometimes decreasing the stress response. The mechanism suggests that this biphasic effect results from increased occupancy of positive a...

journal_title：Medical hypotheses

authors： Gaffney BT,Hügel HM,Rich PA

更新日期：2001-05-01 00:00:00

abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...

journal_title：Medical hypotheses

authors： Tao H,Ge G,Li W,Liang X,Wang H,Li N,Sun H,Zhang W,Geng D

更新日期：2020-12-01 00:00:00

abstract：:A mechanism is proposed for the formation of Ebg-evolved beta galactosidase-of E. coli based on the following assumptions: 1. In the presence of lactose, certain proteins being translated bind to their m-RNA-ribosome complexes; 2. This binding interferes with the release of m-RNA from the bacterial chromosome, marking...

journal_title：Medical hypotheses

authors： Erhan S

更新日期：1979-11-01 00:00:00

abstract：:A hypothesis is proposed here to reconcile the inconsistencies observed in the IQ-P3 latency relation. The hypothesis stems from the observation that task-induced increase in P3 latency correlates positively with IQ scores. It is hypothesised that: (a) there are several parallel information processing pathways of vary...

journal_title：Medical hypotheses

authors： Sircar SS

更新日期：2000-06-01 00:00:00