Postencephalitic Parkinson's disease, amyotrophic lateral sclerosis on Guam and influenza revisited: focusing on neurofibrillary tangles and the trail of tau.


:Circumstantial evidence links neuropathological changes in postencephalitic Parkinson's disease and amyotrophic lateral sclerosis on Guam to the 1918 influenza pandemic. Postencephalitic Parkinson's disease and amyotrophic lateral sclerosis have neuronal neurofibrillary tangles that anatomically correlate with clinical signs and symptoms. Occurrences of the disorders peaked in the early 1950s and are now disappearing. Neurovirulent influenza associated with the lethal 1918 pandemic is suggested as the etiology of both diseases. Permissive tissue antigens are considered an important contributing factor. Neurofibrillary tangles also correlate with signs and symptoms in Alzheimer's disease. Oxidative stress may be the pathological process that induces neurofibrillary tangles. Tangles contain abnormally phosphorylated tau. In Alzheimer's disease, tau is present in cerebrospinal fluid and is deposited in corpora amylacea, demonstrating the direction of cerebrospinal fluid flow.


Med Hypotheses


Medical hypotheses


Maurizi CP





Has Abstract


2002-03-01 00:00:00














  • Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency.

    abstract::An aldehyde-dehydrogenase (ALDH2) deficiency is a biological curb on excess alcohol-drinking. This enzyme deficiency is very common amongst Oriental people while it is relatively rare for most other populations. We observe that there is good geographical correlation between the prevalence of the mutant ALDH2*2 alleles...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lin YP,Cheng TJ

    更新日期:2002-08-01 00:00:00

  • Evolutionary medicine: bottle feeding, birth spacing, and autism.

    abstract::To compensate for the high metabolic costs of lactation, the likelihood of re-impregnation shortly after childbirth is normally reduced due to hormonal changes triggered by breast feeding during the postpartum period. Nowadays, however, bottle feeding as a substitute for breast feeding precludes such changes and leads...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Gallup GG Jr,Hobbs DR

    更新日期:2011-09-01 00:00:00

  • Smoking, lung cancer and hypothesis testing.

    abstract::It has been shown previously that the precipitator hypothesis of causation is able to account for certain key features of the epidemiological evidence that conflict with initiator and promoter hypotheses. The precipitator hypothesis states that the carcinogenic risk depends linearly in the average rate of smoking at a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Burch PR

    更新日期:1981-12-01 00:00:00

  • Combined morphine and limb remote ischaemia postconditioning may produce an enhanced cardioprotection.

    abstract::The limb remote ischaemia postconditioning (RIPOC), a newly conceived idea of applying brief limb ischaemic stimulus after onset of the myocardial ischaemia but prior to the reperfusion, can offer the possibility of applying this cardioprotective strategy to the patients with acute myocardial infraction. Although incr...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Xu YC,Xue FS,Liao X,Xiong J,Yang QY,Wang WL,Zhang YM

    更新日期:2009-09-01 00:00:00

  • Can testosterone replacement decrease the memory problem of old age?

    abstract::The world is rapidly ageing. It is against this backdrop that there are increasing incidences of dementia reported worldwide, with Alzheimer's disease (AD) being the most common form of dementia in the elderly. It is estimated that AD affects almost 4 million people in the US, and costs the US economy more than 65 mil...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Lim D,Flicker L,Dharamarajan A,Martins RN

    更新日期:2003-06-01 00:00:00

  • Elimination communication as colic therapy.

    abstract::Colic is generally defined as excessive crying in early infancy and can have negative consequences on the infant as well as on the infant's family life. Excessive crying can result in escalating parental stress levels, abusive caregiver response, increased risk of shaken baby syndrome and parental postpartum depressio...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jordan GJ

    更新日期:2014-09-01 00:00:00

  • Evolutionary origin of bipolar disorder-revised: EOBD-R.

    abstract::The hypothesis of the evolutionary origin of bipolar disorder (EOBD) synthesized ideas about the biological clock and seasonal shifts in mood (Rosenthal, Wehr) with theorizing that bipolar disorder descends from a pyknic (compact, cold-adapted) group (Kretchmer). The hypothesis suggested that bipolar behaviors evolved...

    journal_title:Medical hypotheses

    pub_type: 历史文章,杂志文章


    authors: Sherman JA

    更新日期:2012-01-01 00:00:00

  • Exploring the role of an endogenous caffeine-like substance in the pathogenesis of schizophrenia.

    abstract::In a previous paper, I have proposed that the deficiency of an endogenous caffeine-like substance is the underlying pathogenic mechanism in schizophrenia (1). In the present paper, my new concept is used to explain many of the clinical, biochemical, radiologic and pharmacologic facts about schizophrenia. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Missak SS

    更新日期:1991-10-01 00:00:00

  • Down-regulation of HLA-G gene expression as an immunogenetic contraceptive therapy.

    abstract::HLA-G is a nonclassical HLA immunotolerogenic molecule expressed in different human cell types. Successful embryo implantation is a consequence of information exchange between the uterus and the blastocyst. It is widely accepted that HLA-G expression by the fetus promotes the establishment of several mechanisms that, ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kaminski V,Ellwanger JH,Chies JAB

    更新日期:2017-05-01 00:00:00

  • Involvement of the central nervous system in neuroblastomas: A potential direct pathway.

    abstract::Although frequently disseminated to other anatomical sites, neuroblastoma (NB) is rarely reported as involving the central nervous system (CNS), which may reflect insufficient research in poorly controlled systemic disease. Here we demonstrate the involvement of the CNS in patients with NB over 18 months of age at dia...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Odone-Filho V,Cristofani LM,Maluf PT,Almeida MTA,Halley N,Vince CSC,de Azambuja AMP,Brumatti M,Lubraico P,da Camara Lopes LHA,Leite KRM,Silva JLF,Plese JPP,Weltman E

    更新日期:2020-03-01 00:00:00

  • An explanation of how migraine headaches can trigger relapse in systemic lupus erythematosus.

    abstract::Except for a few diseases of molecular mimicry such as rheumatic fever, post-streptococcal glomerulonephritis in children, and gluten-sensitive enteropathy, the cause of autoimmune diseases is unknown. Most autoimmune diseases are remitting-relapsing and the pathophysiology of either the initial attack or subsequent r...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Eggers AE

    更新日期:2013-05-01 00:00:00

  • Posterior vitreous wick syndrome: a potential cause of endophthalmitis following vitreo-retinal surgery.

    abstract::Endophthalmitis following pars-plana procedures such as a vitrectomy vitreo-retinal procedures has been infrequently reported in literature. The cited incidence is about 0.1% to 0.2%. In the 8 cases of endophthalmitis that have been reported in literature, the prognosis has been indicated as very poor due to a delay i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Venkatesh P,Verma L,Tewari H

    更新日期:2002-06-01 00:00:00

  • Deep brain stimulation as a possible treatment of hyperthermia in patients with serotonin syndrome.

    abstract::Maintaining a body temperature within a narrow range is vital for the survival of all mammals, including humans. With the help of optogenetics, a better understanding of the thermoregulatory organs and pathways is achieved. Optogenetic activation of the GABAergic neurons in the ventral part of the lateral preoptic nuc...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Koleva K,Pavlov O,Nikolov R,Behr R

    更新日期:2020-06-01 00:00:00

  • Hv1 proton channel possibly promotes atherosclerosis by regulating reactive oxygen species production.

    abstract::Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Zheng Z,Zhang Z,Wang M

    更新日期:2020-08-01 00:00:00

  • Mono-inverted reciprocation of segments from two chromatids.

    abstract::The paper discusses a mechanism for reciprocal translocation of midsegments between two chromatids so that one of the segments is restacked in inverted configuration. Regarding malignant cells, such process could derive from anachronistic assembly of the nuclear envelope. ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Matioli GT

    更新日期:1998-06-01 00:00:00

  • Hypothalamic opioid-melanocortin appetitive balance and addictive craving.

    abstract::Whilst the parallels between drug and food craving are receiving increasing attention, the recently elucidated complex physiology of the hypothalamic appetite regulatory centres has been largely overlooked in the efforts to understand drug craving which is one of the most refractory and problematic aspects of drug and...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Reece AS

    更新日期:2011-01-01 00:00:00

  • A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10.

    abstract::Multiple sclerosis (MS) is a neurodegenerative disease of uncertain etiology. In MS, neurodegeneration is thought to be secondary to autoimmune-mediated damage. However, no cohesive explanation yet exists as to how environmental factors interact to induce a neurodegenerative autoimmune response. Insufficient sunlight ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hayes CE,Donald Acheson E

    更新日期:2008-01-01 00:00:00

  • Effects of electrostatic potentials generated on the surface of the skin by wearing synthetic and semisynthetic fabrics on physical condition, mood and behavior: role of acupuncture points.

    abstract::Synthetic and semisynthetic fabrics generate electrostatic potentials on the surface of the skin. The author suggests that the effects of electrostatic potentials on physical and psychological condition are mediated by acupuncture points. The author further suggests that electrostatic charges on the surface of the ski...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sher L

    更新日期:2000-03-01 00:00:00

  • Possible use of indole-3-acetic acid and its antagonist tryptophan betaine in controlled killing of horseradish peroxidase-labeled human cells.

    abstract::It has been proposed that combination of indole-3-acetic acid (IAA) and horseradish peroxidase (HRP) could be useful as the basis for targeted cancer therapy involving antibody-, polymer-, or gene-directed approaches. By circulating IAA in human body, the cells labeled with HRP could be selectively killed since cytoto...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kawano T

    更新日期:2003-05-01 00:00:00

  • Salt and miscarriage: Is there a link?

    abstract::Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmun...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Abdoli A

    更新日期:2016-04-01 00:00:00

  • Human fetal skin fibroblasts: Extremely potent and allogenic candidates for treatment of diabetic wounds.

    abstract::The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

    更新日期:2015-06-01 00:00:00

  • On the oncodevelopmental role of human imprinted genes.

    abstract::Genome imprinting has an essential role in normal embryonal mammalian development. Starting early in differentiation, the transcripts of certain human genes, e.g. the paternally-H19 and the maternally-imprinted IGF2, are expressed in specific tissues and organs during fetal life. In several malignant disorders, imprin...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Biran H,Ariel I,De Groot N,Hochberg A

    更新日期:1994-08-01 00:00:00

  • Stress-induced suppression of the cellular immune reactions: on the neuroendocrine control of the immune system.

    abstract::Immune competence is considered as a state of equilibrium between humoral and cellular immunity. This notion fits well with the functionally antagonistic cytokine profiles in cell groups of CD4(+)-helper cells as described by Mosmann and Coffman. The Th-1 cells release mainly IL-2, IL-12 and IFN gamma and thereby stim...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hässig A,Wen-Xi L,Stampfli K

    更新日期:1996-06-01 00:00:00

  • X-ray induced thyroid adenocarcinoma.

    abstract::A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable c...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Rosen P

    更新日期:1984-04-01 00:00:00

  • A new therapeutic candidate for oral aphthous ulcer: Allicin.

    abstract::Recurrent aphthous ulcer (RAU) is the most common ulcer of oral non-keratinized mucosa, but the treatment is always limited at present. Considering the multifactorial etiology of RAU, a novel therapeutic agent with multi-bioactivties should be presented. Garlic has been recognized as a favorable natural medicine again...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Jiang XW,Hu J,Mian FI

    更新日期:2008-12-01 00:00:00

  • GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.

    abstract::Noonan syndrome (NS OMIM 163950) is a relatively common autosomal dominant developmental disorder characterized by short stature, specific facial features, and congenital cardiac anomalies. Approximately 50-66% of cases have defined mutations in the K-ras/Raf/MEK/ERK pathway that lead to constitutive signaling, but a ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Huang X,Fu Y,Charbeneau RA,Neubig RR

    更新日期:2009-07-01 00:00:00

  • A proposed tandem mechanism for memory storage in neurons involving magnetite and prions.

    abstract::Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Alfsen EM,Størmer FC,Njå A,Walløe L

    更新日期:2018-10-01 00:00:00

  • A possible haemodynamic mechanism for amyotrophic lateral sclerosis.

    abstract::The hypothesis proposed in this article is that a haemodynamic mechanism may cause amyotrophic lateral sclerosis (ALS). The hypothesis is synthesized from three separate streams of medical research: (1) multiple sclerosis (MS) research; (2) ALS research; (3) atherosclerosis research. Each research stream was reviewed ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Arhart RW

    更新日期:2010-10-01 00:00:00

  • Are some melanomas caused by artificial light?

    abstract::The incidence rate of cutaneous melanoma has been increasing faster than that of any other cancer in white-skinned populations over the past decades. The main risk factors for melanoma (i.e. exposure to sunlight, naevus count, phototype, and family history of melanoma) may not wholly explain the epidemiological trends...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Kvaskoff M,Weinstein P

    更新日期:2010-09-01 00:00:00

  • Deleterious effects of prostaglandin E2 in oesophageal carcinogenesis.

    abstract::Oesophageal carcinoma is a devastating disease with a poor prognosis. This hypothesis shows how prostaglandin E2 exerts carcinogenic effects in the oesophagus. The contribution of prostaglandin E2 is related to other factors that predispose to oesophageal carcinoma. The implication of the hypothesis is that nonsteroid...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Morgan G

    更新日期:1997-02-01 00:00:00