Abstract：
:Tubulointerstitial fibrosis is a final common pathway to the eventual structural desolation of kidneys. However, the mechanism involved in this phenomenon is still poorly understood, and current therapies are ineffective or only marginally effective. Mast cell has a variety of physiological and pathological functions through the production of heparin, histamine, neutrophil chemoattractants, immunoregulatory cytokines, and mast cell-specific serine proteases tryptase and chymase. The survival and proliferation of mast cell are dependent upon stem cell factor. Presently, mast cells are known to participate in the pathogenesis of tubulointerstitial fibrosis in many kidney diseases. Several therapeutic approaches to inhibit mast cell activation have already demonstrated some clinical utility in tissue fibrosis or inflammatory diseases such as the use of mast cell stabilizers, inhibitors of tryptase or chymase, blockade of stem cell factor and anti-IgE therapy. We hypothesize that mast cell has a significant role in the progression of tubulointerstitial fibrosis, thus the treatment strategies based on mast cell appear to be promising in these conditions. Development of these novel therapeutic approaches will enable us to target any types of renal disease.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Li Y,Liu FY,Peng YM,Li J,Chen Jdoi
10.1016/j.mehy.2006.10.059subject
Has Abstractpub_date
2007-01-01 00:00:00pages
99-103issue
1eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00854-1journal_volume
69pub_type
杂志文章abstract：:For many years there was a general belief that the enzyme renin, having been secreted into the circulation by the kidney in response to appropriate stimuli, initially generates the inactive decapeptide angiotensin I in the bloodstream. This is then converted to the biologically active octapeptide angiotensin II by ang...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1201
更新日期：2001-04-01 00:00:00
abstract：:Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metaboli...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.05.025
更新日期：2012-09-01 00:00:00
abstract：:Preterm birth is an important perinatal health problem. Several possible mechanisms have been proposed but it may be important to have a testable mechanistic hypothesis that can explain the possible common mechanism for preterm births around the globe. Altered metabolism of micronutrients, like folic acid, vitamin B(1...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.08.001
更新日期：2011-11-01 00:00:00
abstract：:The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single l...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109318
更新日期：2019-11-01 00:00:00
abstract：:Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.04.046
更新日期：2009-11-01 00:00:00
abstract：:Benign intracranial hypertension and communicating hydrocephalus are uncommon but important disorders that affect cerebrospinal fluid dynamics. They have clinical similarities but their management is usually different. The factors determining which of the two disorders will develop include brain compliance, the state ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(97)90081-5
更新日期：1997-11-01 00:00:00
abstract：:It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.01.046
更新日期：2007-01-01 00:00:00
abstract：:Contrast-induced nephropathy (CIN) is regarded as acute tubular necrosis resulting from the cytotoxicity of contrast media and the medullary hypoxia linking to the interplay of vasoconstriction and vasodilatation. Saline infusion may prevent CIN by inhibiting renin release and thus production of angiotensin II (ANG II...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.09.020
更新日期：2015-12-01 00:00:00
abstract：:Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. V...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0695
更新日期：1999-06-01 00:00:00
abstract：:Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues to elude medical science. Antiepileptic drug (AED) therapy fails to control seizures in 20% of patients with primary generalized epilepsy and 35% of patients with partial epil...
journal_title：Medical hypotheses
pub_type： 历史文章,杂志文章
doi：10.1016/s0306-9877(02)00348-1
更新日期：2003-01-01 00:00:00
abstract：:Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmun...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.02.003
更新日期：2016-04-01 00:00:00
abstract：:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic disease in adults, and it is thought to be increasing in incidence. FSGS is often difficult to treat and even has a high propensity to relapse after transplant. Indeed, this suggests that there might be some circulating factor responsible for pro...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1438
更新日期：2001-12-01 00:00:00
abstract：:The prevalence of atopic diseases (atopic dermatitis, bronchial asthma, allergic rhinitis) has considerably increased for the last 40 years. This tendency has coincided with the beginning of the epoch of the use of the topical corticosteroids, which have a potent immunomodulation action. This fact itself as well as a ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.059
更新日期：2005-01-01 00:00:00
abstract：:A possible mechanism for maintaining immune memory, based on idiotypic-anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2000.1132
更新日期：2001-02-01 00:00:00
abstract：:The per review system for the assessment of research proposals is widely respected by working scientists. Nevertheless two problems associated with the operation of this system by the US National Institutes of Health are identified. First the scientist has no control over which committee will review an application and...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(76)80019-9
更新日期：1976-01-01 00:00:00
abstract：:Burnout is a state of physical or mental collapse caused by overwork or stress. Burnout during residency training has gained significant attention secondary to concerns regarding job performance and patient care. The new COVID-19 pandemic has raised public health problems around the world and required a reorganization...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109972
更新日期：2020-11-01 00:00:00
abstract：:Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.11.010
更新日期：2018-01-01 00:00:00
abstract：:The number of deaths per year from hepatocellular carcinoma (HCC) exceeds 250000, placing it sixth as the cause of death from cancer worldwide. The primary etiology of most cases of HCC in the US is hepatitis B and/or C. Extensive research has demonstrated that the relationship between hepatitis B infection and the pr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00263-9
更新日期：2004-01-01 00:00:00
abstract：:We recently demonstrated that amyloid beta peptide (Abeta) is catabolized primarily by a neutral endopeptidase, neprilysin, in the brain and that a neuropeptide, somatostatin (SST), regulates brain Abeta level via modulation of neprilysin activity. Because SST expression in the brain declines upon aging in various mam...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.045
更新日期：2005-01-01 00:00:00
abstract：:Over-proliferation of SMC (smooth muscle cell) is one characteristics of atherosclerosis. One well accepted mechanism is that the decrease of ECs (endothelial cells) induced by over apoptosis leads to endothelial dysfunction, which in turn results in over-proliferation of SMC. Obviously, the mechanism works after endo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.07.037
更新日期：2007-01-01 00:00:00
abstract：:Extracts of the unripe fruit of Momordica charantia--bitter melon, which flourishes throughout the tropics--appear to have utility in the management of type 2 diabetes. Rodent studies suggest that the thus-far-uncharacterized active components of such extracts enhance the efficiency of postprandial glucose storage in ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.01.041
更新日期：2004-01-01 00:00:00
abstract：:Following allegations that Hepatitis B vaccination causes or triggers multiple sclerosis (MS), several epidemiological studies have been conducted to evaluate the association between MS and vaccination. In one study conducted in the US, a significant protective effect on the development of MS was observed for tetanus ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.05.009
更新日期：2005-01-01 00:00:00
abstract：:Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.03.023
更新日期：2008-08-01 00:00:00
abstract：:Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulat...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1997.0655
更新日期：1999-05-01 00:00:00
abstract：:Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5-10% of cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of SARS-CoV-2 and its pathology of associated acute lung injury (ALI), acute respiratory distress syndrome (ARDS), sepsis, coagulopathy and mu...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109906
更新日期：2020-10-01 00:00:00
abstract：:Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90226-1
更新日期：1996-01-01 00:00:00
abstract：:Chronic, tertiary Lyme disease, a vector-borne infection most accurately designated neuroborreliosis, is often misdiagnosed. Infectors of the human brain, Lyme borrelial spirochetes are neurotropic, similar to the spirochetes of syphilis. Symptoms of either disease may be stable and persistent, transient and inconsist...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.04.009
更新日期：2005-01-01 00:00:00
abstract：:Irritable Bowel Syndrome (IBS) is a condition that may be marked by abdominal pain, bloating, fullness, indigestion, belching, constipation and/or diarrhea. IBS symptoms can result from malabsorption of fructose. Fructose is a monosaccharide found naturally in small quantities in fruits and some vegetables, and in muc...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.05.019
更新日期：2015-09-01 00:00:00
abstract：:It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and diff...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90185-0
更新日期：1989-07-01 00:00:00
abstract：UNLABELLED:CRPS is an acute pain disease expressed as chronic pain with a severe loss of tissue and function. CRPS usually occurs after minor injuries and then progresses in a way that is scarcely controllable, or completely uncontrollable. This article addresses the functional control mechanism of a biological organis...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2015.07.017
更新日期：2015-11-01 00:00:00
