Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide.

abstract：:The comorbidity of eating disorders and reflex sympathetic dystrophy syndrome in the same patients raises the possibility of a common pathway for both conditions. Reflex sympathetic dystrophy syndrome may be manifesting itself in those individuals who have sympathetic overdrive. Microtrauma, often induced by compulsiv...

journal_title：Medical hypotheses

authors： Silber TJ

更新日期：1997-03-01 00:00:00

abstract：:The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...

journal_title：Medical hypotheses

authors： Wendorf MA

更新日期：1999-05-01 00:00:00

abstract：:There is no secret that despite the rapid development of new methods of cancer therapy, we still are not able to completely destroy the tumor. Every time we attack the tumor, the tumor neutralizes our attempts. Carcinogenesis can be presented as a tree whose branches are different pro-tumor mechanisms and whose trunk ...

journal_title：Medical hypotheses

authors： Malyshev IY,Kuznetsova LV,Mardente S

更新日期：2020-04-01 00:00:00

abstract：:Most of the body iron is found within hemoglobin in red cells (the erythron), a smaller amount being distributed in other tissues such as muscles and in deposits. Iron homeostasis is a finely tuned process in which the most important regulators are probably the liver-derived hepcidin which blocks iron absorption and d...

journal_title：Medical hypotheses

authors： Cucuianu A,Patiu M,Trifa AP,Tomuleasa C,Dima D

更新日期：2014-11-01 00:00:00

abstract：:This study investigated whether or not the anesthetic effect of ketamine in rats is dependent on adrenal gland hormones. The study was performed on two main rat groups, intact and adrenalectomized. Rat were divided into subgroups and given appropriate doses of ketamine, metyrapone or metyrosine. Durations of anesthesi...

journal_title：Medical hypotheses

authors： Aksoy M,Ince I,Ahiskalioglu A,Dostbil A,Celik M,Turan MI,Cetin N,Suleyman B,Alp HH,Suleyman H

更新日期：2014-07-01 00:00:00

abstract：:The biophysical processes during electroconvulsive therapy (ECT) are discussed. The multilayer head structure causes a shunting and spreading of the major portions of the current all over the extracranial tissues. The final effect is that only a small percentage of the injected current passes into the brain. The secon...

journal_title：Medical hypotheses

authors： Zyss T

更新日期：1994-08-01 00:00:00

abstract：:Lactic acid produced by the malignant tumor is what keeps the malignancy going. Suppression or the removal of lactic acid is the prerequisite for any cancer treatment. ...

journal_title：Medical hypotheses

authors： Niakan B

更新日期：2001-05-01 00:00:00

abstract：:Regulation of ion transport across the airway mucosa may be involved in the mechanisms producing hyperreactivity and asthma. Atrial Natriuretic Peptide (ANP) has been proposed to participate in the pathogenesis of asthma, and it has been found to have a bronchodilatory effect on asthmatic patients. Experimental eviden...

journal_title：Medical hypotheses

authors： Almirall JJ,Hedenstierna G

更新日期：1991-09-01 00:00:00

abstract：:Numerous studies indicate that aberrant amyloid precursor protein metabolism, elevated peroxidative damage, depressed energy metabolism and altered calcium homeostasis are four pivotal deleterious factors in the pathogenesis of Alzheimer's disease. Cumulative evidence further suggests that these four factors are intim...

journal_title：Medical hypotheses

authors： Ying W

更新日期：1996-05-01 00:00:00

abstract：:Based on a consideration of biochemical mechanisms, rational methods for the prevention of cancer and for its positive regression are presented. It is demonstrated that the means employed are fundamentally opposed so that if the preventive method were to be used after the onset of cancer, it would only accelerate its ...

journal_title：Medical hypotheses

authors： Duchesne J

更新日期：1981-04-01 00:00:00

abstract：:Chloroquine is one of the antimalaria drugs, also used to treat rheumatoid arthritis and systemic lupus erythematosus (SLE). Although well tolerated in most individuals, it was suggested that chloroquine can exert a profound influence on renal function, especially in individuals with compromised body fluid status. How...

journal_title：Medical hypotheses

authors： Ahmed MH,Osman MM

更新日期：2007-01-01 00:00:00

abstract：:Diabetic individuals frequently suffer from skin pathologies, especially in their feet. Co-existing peripheral vascular disease and neuropathy exacerbate the capacity of these individuals to cope with infections, minor cuts and wounds, often leading to hard to treat and chronic ulcers. Copper has potent anti-fungal an...

journal_title：Medical hypotheses

authors： Borkow G,Zatcoff RC,Gabbay J

更新日期：2009-12-01 00:00:00

abstract：:Erectile dysfunction after nerve injury is a common disease after radical prostatectomy. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. It has been demonstra...

journal_title：Medical hypotheses

authors： Chiang PK,Yang FY

更新日期：2019-01-01 00:00:00

abstract：:The three events, viz. schizophrenia, dissociative anaesthesia and Near-Death Experience, despite their seemingly unrelated manifestation to each other, have nevertheless similar functional basis. All three events are linked to the glutamate sensitive N-methyl-D-aspartate (NMDA) receptor complex, which serves as their...

journal_title：Medical hypotheses

authors： Bonta IL

更新日期：2004-01-01 00:00:00

abstract：:A wide range of hyperimmune-associated diseases plague post-industrial society, with a prevalence and impact that is staggering. Strong evidence points towards a loss of helminths from the ecosystem of the human body (the human biome) as the most important factor in this epidemic. Helminths, intestinal worms which are...

journal_title：Medical hypotheses

authors： Bilbo SD,Wray GA,Perkins SE,Parker W

更新日期：2011-10-01 00:00:00

abstract：:Over the last century and a half there has been a secular decline in the age of menarche in Western, industrialized cultures. This trend has been largely ascribed to improved nutrition and health, and we offer an alternative hypothesis that changes in socio-economic conditions have resulted in changes in the pheromona...

journal_title：Medical hypotheses

authors： Burger J,Gochfeld M

更新日期：1985-05-01 00:00:00

abstract：:Purpura fulminans is a life threatening complication of many septic states, most notably meningococcaemia. It can also occur due to congenital deficiency of anticoagulant proteins. The pathophysiology of purpura fulminans is complex and not fully understood, but involves abnormalities of coagulation pathways, damage t...

journal_title：Medical hypotheses

authors： Oram J,Bodenham A

更新日期：2008-01-01 00:00:00

abstract：:Primary hyperparathyroidism is one of the most common causes of hypercalcemia. Most cases result from sporadic benign monoclonal adenomas or hyperplasia. Increased body weight is consistently present in cohorts of patients with primary hyperparathyroidism. It has been shown that fat mass is the major determinant of se...

journal_title：Medical hypotheses

authors： Cheng SP,Doherty GM,Chang YC,Liu CL

更新日期：2011-01-01 00:00:00

abstract：:The pathogenesis of seasonal affective disorder (SAD) has been attributed to abnormal melatonin metabolism. Perorally administered psoralens increase the daytime levels of melatonin via the competitive inhibition of hepatic melatonin metabolism. Some findings among SAD patients are parallel to those observed after the...

journal_title：Medical hypotheses

authors： Partonen T

更新日期：1998-06-01 00:00:00

abstract：:Trypanosomiasis is common in Africa and South America. The surface of trypanosomes is covered by glycosyl phosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) that contains the fatty acid myristate (14:0) as its lipid moiety that is essential for its survival. Myristic acid, being a saturated fatty a...

journal_title：Medical hypotheses

authors： Das UN

更新日期：2010-04-01 00:00:00

abstract：:Diabetes is a metabolic condition associated with hyperglycemia manifested by the elevation of blood glucose levels occurring when the pancreas decreases or stops the production of insulin, in case of insulin resistance or both. The current literature supports that insulin resistance may be responsible for the memory ...

journal_title：Medical hypotheses

authors： Leão LL,Tangen G,Barca ML,Engedal K,Santos SHS,Machado FSM,de Paula AMB,Monteiro-Junior RS

更新日期：2020-06-01 00:00:00

abstract：:Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...

journal_title：Medical hypotheses

authors： Kluger N

更新日期：2012-05-01 00:00:00

abstract：:Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor, we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor. We discuss t...

journal_title：Medical hypotheses

authors： Corrigan FM,MacDonald S,Brown A,Armstrong K,Armstrong EM

更新日期：1994-10-01 00:00:00

abstract：:Atherosclerosis develops gradually as a subclinical condition and eventually becomes clinically apparent as heart disease or stroke. The degree of decreased arterial compliance affects both pulse pressure (PP) and diastolic blood pressure (DBP). These relations would be clear in the distal periphery. We propose that t...

journal_title：Medical hypotheses

authors： Nesnawy S,Tolba K,Roshdy I,Abdel Kader M

更新日期：2020-02-01 00:00:00

abstract：:The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocul...

journal_title：Medical hypotheses

authors： Sahu DK,Pradhan D,Naik PK,Kar B,Ghosh G,Rath G

更新日期：2020-11-01 00:00:00

abstract：:Deciding for an amputation in case of complex regional pain syndrome type I (CRPS-I) is controversial. Evidence for favorable or adverse effects of an amputation is weak. We therefore follow a careful and well-structured decision making process. After referral of the patient with the request to amputate the affected l...

journal_title：Medical hypotheses

authors： Schrier E,Dijkstra PU,Zeebregts CJ,Wolff AP,Geertzen JHB

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...

journal_title：Medical hypotheses

authors： Tavakol S

更新日期：2014-12-01 00:00:00

abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...

journal_title：Medical hypotheses

authors： Royall DR

更新日期：2013-02-01 00:00:00

abstract：:Ampligen, a mismatched double stranded RNA, is hypothesized to be an ideal base therapy for HIV disease to which other agents, such as the nucleoside analogue, AZT, can be advantageously added. The unique properties of Ampligen which support this hypothesis include activation of immune cells, inhibition of virus repli...

journal_title：Medical hypotheses

authors： Gillespie D,Carter WA

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...

journal_title：Medical hypotheses

authors： Poonsiri J,van Putten SWE,Ausma AT,Geertzen JHB,Dijkstra PU,Dekker R

更新日期：2020-10-01 00:00:00