Abstract:
:At the end of 2019, an emerging outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first reported from Wuhan, China. The first manifestations of patients infected with SARS-CoV-2 was flu-like symptoms, while other type of manifestations, especially gastrointestinal manifestations were discovered recently. As of June 2020, there is no specific drug or treatment strategy for COVID-19, a disease caused by SARS-CoV-2, so different combination of antiviral drugs is currently being used. Gut microbiota mostly consists of four phyla, including Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. The interaction between gut microbiota and immune system through releasing some cytokines such as IL-1β, IL-2, IL-10, TNF-α, and IFN-γ that play roles in the severity of COVID-19. In this article, a new potential treatment for COVID-19 by fecal microbiota transplantation (FMT) is described. FMT revealed promising results in different diseases, especially recurrent clostridium difficile infection, and it might reduce length of hospital admission and severity of the disease by modification of gut microbiota composition.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Nejadghaderi SA,Nazemalhosseini-Mojarad E,Asadzadeh Aghdaei Hdoi
10.1016/j.mehy.2020.110476subject
Has Abstractpub_date
2020-12-31 00:00:00pages
110476eissn
0306-9877issn
1532-2777pii
S0306-9877(20)33367-3journal_volume
147pub_type
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90105-9
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doi:10.1016/j.mehy.2007.10.013
更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.03.011
更新日期:2014-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.11.012
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0999
更新日期:2000-06-01 00:00:00
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journal_title:Medical hypotheses
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更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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