Fecal microbiota transplantation for COVID-19; a potential emerging treatment strategy.

Abstract:

:At the end of 2019, an emerging outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first reported from Wuhan, China. The first manifestations of patients infected with SARS-CoV-2 was flu-like symptoms, while other type of manifestations, especially gastrointestinal manifestations were discovered recently. As of June 2020, there is no specific drug or treatment strategy for COVID-19, a disease caused by SARS-CoV-2, so different combination of antiviral drugs is currently being used. Gut microbiota mostly consists of four phyla, including Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. The interaction between gut microbiota and immune system through releasing some cytokines such as IL-1β, IL-2, IL-10, TNF-α, and IFN-γ that play roles in the severity of COVID-19. In this article, a new potential treatment for COVID-19 by fecal microbiota transplantation (FMT) is described. FMT revealed promising results in different diseases, especially recurrent clostridium difficile infection, and it might reduce length of hospital admission and severity of the disease by modification of gut microbiota composition.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Nejadghaderi SA,Nazemalhosseini-Mojarad E,Asadzadeh Aghdaei H

doi

10.1016/j.mehy.2020.110476

subject

Has Abstract

pub_date

2020-12-31 00:00:00

pages

110476

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(20)33367-3

journal_volume

147

pub_type

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