Abstract：
:Recent advances into the neuroscience research related to pathophysiology of schizophrenia have been impressive. While some are based on pre-existing theories and models, others have explored on a molecular level attempting to integrate the concepts of the past and present. However, given the complex multifactorial etiology of schizophrenia attempts to improve the current treatment modalities raise more questions than answers. In the cascade model of the hypotheses, the focus will be on a common factor/marker for the disease, to address the possible stepwise correlation between the various theories. Homeostasis of calcium, its relation to the release of glutamate, dopamine and nitric oxide will be discussed in detail with the potential for interventions aimed at every stage. Although this hypothesis emphasizes the role of calcium as a common factor, other potential causes such as autoantibodies to the receptors, such as NMDA (and GABA) cannot be ruled out.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Yarlagadda Adoi
10.1054/mehy.2001.1511keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
182-6issue
2eissn
0306-9877issn
1532-2777pii
S0306987701915117journal_volume
58pub_type
杂志文章abstract：:Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe), manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium (Ca) - have been observed in the foodchains that traditionally support the Chamorro populations affected by high incidence clusters of Alzheimer (AD), Parkinson-like ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.04.029
更新日期：2004-01-01 00:00:00
abstract：:The paper discusses certain dynamic processes leading to meiotic (haploid) partition of chromatids via the chiasmatic mode in mammalian spermatic cells. The achiasmatic case is also reviewed briefly and only in the context of homologs with centromeric braids arrayed in the Para configuration. ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(94)90013-2
更新日期：1994-12-01 00:00:00
abstract：:Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or in...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.12.019
更新日期：2018-02-01 00:00:00
abstract：:The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.10.006
更新日期：2012-01-01 00:00:00
abstract：:Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndr...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.01.029
更新日期：2007-01-01 00:00:00
abstract：:It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...
journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2007.12.004
更新日期：2008-01-01 00:00:00
abstract：:Hyperplasia of the coronoid process of the mandible has been observed in conditions like Oral submucous fibrosis, TMJ ankylosis, etc. The etiopathogenesis of this coronoid overgrowth has not been clearly sequenced or adequately hypothesized, and no definite mechanism has so far been advocated to explain this elongatio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.07.058
更新日期：2011-11-01 00:00:00
abstract：:Recent findings indicate a principal role for Hepcidin in iron homeostasis. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. Under normal conditions influx and efflux of iron from duodenal enterocytes is regulated by Ferroportin. Fer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.10.007
更新日期：2008-01-01 00:00:00
abstract：:The origin and initiating features of PBC remain obscure despite decades of study. However, recent papers have demonstrated loss of canals of Hering (CoH) to be the earliest histologic change in liver biopsy specimens from patients with primary biliary cholangitis (PBC). We posit that CoH loss prior to significant inf...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109680
更新日期：2020-03-16 00:00:00
abstract：:The hypothesis is put forward that coronary heart disease (CHD) arises from a chronic imbalance between anabolism and catabolism in the body, induced by the psychosocial environment and mediated through the central nervous system (CNS) and neuroendocrine system. Psychosocial demands increase periods of waking arousal ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90044-0
更新日期：1983-11-01 00:00:00
abstract：:Pinealectomy leads to increased formation of fibrous tissue in the abdominal cavity, increased skin pigmentation and elevated cholesterol and alkaline phosphatase levels. It also leads to reduced formation and/or action of prostaglandin (PG) E1 and thromboxane (TX) A2. PGE1 plays an important role in enhancing functio...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(79)90107-5
更新日期：1979-04-01 00:00:00
abstract：:Alpha-fetoprotein (AFP) is overexpressed in the majority of hepatocellular carcinomas (HCCs), and thus may offer attractive target for immunotherapy against this neoplasm. CD40 ligand (CD40L) is the major signal that induces B cells to efficiently present antigen to T cells, and CD40-activated B (CD40-B) lymphocyte ce...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.12.050
更新日期：2009-11-01 00:00:00
abstract：:Contributory risk factors to premature coronary artery disease (CAD) in premenopausal women are poorly understood and data on this subset of women is lacking. There is growing evidence that the process of inflammation is a part of the atherosclerotic process. Mechanistic insights from animal work suggest that the prof...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.09.010
更新日期：2017-11-01 00:00:00
abstract：:Cancer is the second cause of death worldwide, but current therapies are often insufficient or linked with toxicity. Initial evidence in scientific literature seems to support the role of non-pharmacological strategies, including hypoglycemia, in cancer treatment. The biological rationale for hypoglycemia-based treatm...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109276
更新日期：2019-09-01 00:00:00
abstract：:A case-control study was conducted in order to test the hypothesis that a reduced exposure to human seminal factors in the early reproductive life of women is a risk factor in breast cancer. The relative risk of exposure to the hypothetical semen-factor deficiency is 4.7 times greater for breast-cancer patients than f...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(78)90051-8
更新日期：1978-03-01 00:00:00
abstract：:A new hypothesis concerning the association of low levels of steroid hormones and hypercholesterolemia is proposed. This study presents data that concurrent restoration to youthful levels of multiple normally found steroid hormones is able to normalize or improve serum total cholesterol (TC). We evaluated 20 patients ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00324-9
更新日期：2002-12-01 00:00:00
abstract：:An association between Alzheimer's Disease (AD) and low CSF and serum vitamin B12 (B12) has recently been described (1, 2, 3). This is apparently independent of nutritional intake (4). It has been suggested that such patients may exhibit an atypical form of cobalamin deficiency (3, 4). It is therefore proposed that th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90074-m
更新日期：1992-03-01 00:00:00
abstract：:Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2007.10.016
更新日期：2008-01-01 00:00:00
abstract：:Clinical studies have shown that ionic zinc (Zn2+) dissolved in the mouth shortened manifestations of the common cold significantly, by an unknown mechanism. The observed immediate effect on symptoms is consonant with osmotic transport of Zn2+, placing a temporary chemical clamp on critical nerves. It is proposed that...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(96)90259-5
更新日期：1996-03-01 00:00:00
abstract：:Cystic fibrosis-related diabetes (CFRD) has emerged in the last thirty years as a critical complication of cystic fibrosis (CF) and is present in about 15% of CF patients with increasing prevalence with age approaching 50 for over 30 year olds. The mechanism of diabetes development in this group of patients is not ver...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.07.058
更新日期：2009-01-01 00:00:00
abstract：:A hypothesis is proposed here to reconcile the inconsistencies observed in the IQ-P3 latency relation. The hypothesis stems from the observation that task-induced increase in P3 latency correlates positively with IQ scores. It is hypothesised that: (a) there are several parallel information processing pathways of vary...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0979
更新日期：2000-06-01 00:00:00
abstract：:Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.10.011
更新日期：2013-01-01 00:00:00
abstract：:The cancer cell appears to contain two non phosphorylating glycolytic pathways in addition to phosphorylating glycolysis and the aerobic citric acid and phosphogluconate cycles. It is hypothesised that these pathways are all interconnected and in the static adult cell non phosphorylating glycolysis is in a state of co...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(83)90017-8
更新日期：1983-02-01 00:00:00
abstract：:Breast cancer associated with pregnancy is defined as the one in which the diagnosis is made in a pregnancy or within one year of delivery. Breast cancer is the second most common malignancy during pregnancy and it is generally considered to have a worse prognosis than the one that is not associated with pregnancy. Th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.05.072
更新日期：2007-01-01 00:00:00
abstract：:In this paper I hypothesize that a woman through her vagina absorbs sufficient quantities of the prostaglandins from her partner's semen, to affect her mood. The vagina appears to have an active transport mechanism which readily absorbs the hormones found in seminal plasma. The seminal secretions include estrogens, F....
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90128-3
更新日期：1986-06-01 00:00:00
abstract：:Open-angle glaucoma, idiopathic intracranial hypertension, and Meniere's disease are disorders managed by different specialties in medicine viz. ophthalmology, neurology, and otorhinolaryngology respectively. By working in silos, the similarity of these disorders is overlooked. Close inspection of these disorders reve...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.109361
更新日期：2019-11-01 00:00:00
abstract：:This paper describes a presumptive mechanism for the development of changes in respiratory function due to chronic neck pain. The patient with neck pain presents a number of factors that could constitute a predisposition of leading to a respiratory dysfunction: (a) the decreased strength of deep neck flexors and exten...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2007.07.050
更新日期：2008-01-01 00:00:00
abstract：:Intrauterine growth retardation (IUGR) is associated with insulin resistance, non-insulin-dependent diabetes mellitus (NIDDM) and cardiovascular diseases in adulthood. Postnatal tissues contain stem cells that though quiescent, retain their capacity to self-renew and regenerate tissues to fulfil organ demands. I propo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(03)00182-8
更新日期：2003-09-01 00:00:00
abstract：:Cannabinoid hyperemesis syndrome (CHS), a variant of cyclic vomiting syndrome, is an enigmatic and challenging clinical disorder. As cannabis legalization, use, and potency has increased worldwide over the past decade, so has the prevalence of CHS. These patients often require acute care and inpatient treatment for re...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.04.018
更新日期：2017-06-01 00:00:00
abstract：:Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.07.003
更新日期：2018-10-01 00:00:00
