Abstract:
:Cancer is the second cause of death worldwide, but current therapies are often insufficient or linked with toxicity. Initial evidence in scientific literature seems to support the role of non-pharmacological strategies, including hypoglycemia, in cancer treatment. The biological rationale for hypoglycemia-based treatment of cancer resides in the evidence that cancer cells predominantly utilize glucose as an energy source; notably, cancer cells seem to have damaged glycolysis regulation and few, defective mitochondria showing impaired oxidative phosphorylation. Preliminary data arising from both preclinical and human studies support the role of hypoglycemia in inducing apoptosis on cancer cells. In this paper, we describe how to induce and maintain severe hypoglycemia without causing damage to either the brain or the heart. Our hypothesis is that ExtraCorporeal Membrane Oxygenation (ECMO) and selective glucose perfusion of the carotid vessels are able to maintain severe hypoglycemia without causing cardiac or brain damage. This will allow physicians to study the effect of severe hypoglycemia on cancer cell apoptosis in vivo.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Baiardo Redaelli M,Zangrillo A,Gregorc V,Ciceri F,Dagna L,Tshomba Y,Navalesi P,Landoni Gdoi
10.1016/j.mehy.2019.109276subject
Has Abstractpub_date
2019-09-01 00:00:00pages
109276eissn
0306-9877issn
1532-2777pii
S0306-9877(19)30114-8journal_volume
130pub_type
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