Abstract：
:Many clinical trials have clearly demonstrated the benefit of statins in the prevention of coronary heart disease. Although other effects have subsequently been described, the so-called pleiotropic effects of statins, there is a tendency to relate all those effects, more or less directly, to inhibition of 3-hydroxy-3-methylglutaryl coenzyme A. Several clinical and laboratory studies show an association between statins and increased bone formation and/or density, but no clear explanation for that statin effect has emerged. We therefore hypothetized that statins may have an effect on alkaline phosphatase activity (ALP), an enzyme with an important role in bone mineralization and that may also contribute to pathological mineralization in other tissues, such as vascular calcification. Our experience with drug effects on ALP lead us to admit the possibility of finding a statin with an ALP increasing effect on bone but not on vascular tissue, or with a more marked effect upon one of the ALP isoforms or isoenzymes. That information would allow the design of clinical trials to confirm the suitability of a specific statin to a specific clinical condition.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Negrão MR,Mota A,Azevedo I,Martins MJdoi
10.1016/j.mehy.2006.02.046subject
Has Abstractpub_date
2006-01-01 00:00:00pages
524-8issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00187-3journal_volume
67pub_type
杂志文章abstract：:Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for t...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109671
更新日期：2020-03-14 00:00:00
abstract：:Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and a...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2017.07.021
更新日期：2017-10-01 00:00:00
abstract：:The assessment of nature and the extent of extraocular muscle injuries during initial visit in ocular emergencies is of paramount importance to avoid/minimize the subsequent need for strabismus surgery. Based on our experience in managing acute globe and orbital injuries and cases of strabismus, we propose the probabl...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2019.01.011
更新日期：2019-02-01 00:00:00
abstract：:Restless legs syndrome (RLS) exhibits sensorimotor symptoms. In familial cases, a gene at chromosomal location 9p-24-22 is linked to RLS and the expressed mutation is Dopamine Receptor Specific Individual Sensitivity (DRSIS). The symptoms are triggered during changes in alertness, generally at sleep hours, resulting f...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.02.028
更新日期：2009-08-01 00:00:00
abstract：:In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90284-6
更新日期：1991-08-01 00:00:00
abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.03.025
更新日期：2011-07-01 00:00:00
abstract：:Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.02.032
更新日期：2018-05-01 00:00:00
abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPR...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110089
更新日期：2020-10-01 00:00:00
abstract：:Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...
journal_title：Medical hypotheses
pub_type： 社论,历史文章,评审
doi：10.1016/j.mehy.2010.01.038
更新日期：2010-05-01 00:00:00
abstract：:Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metaboli...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.05.025
更新日期：2012-09-01 00:00:00
abstract：:The prevalence of adult and childhood obesity are increasing. Most of the human newborn's body fat accumulates in the last half of intrauterine life. Fat in the fetus was thought to be mostly synthesized from glucose, but now it is commonly accepted that the bulk of it is the product of placental transfer of maternal ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2018.10.022
更新日期：2019-01-01 00:00:00
abstract：:Many risk factors that promote cardiovascular disease (CVD) have been identified. These include hypertension, hypercholesterolemia, diabetes, decreased estrogen in post-menopausal women, increased homocysteine, and cigarette smoking. It has recently become clear that a mechanism common to these risk factors is oxidati...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2007.10.016
更新日期：2008-01-01 00:00:00
abstract：:This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal period...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.06.006
更新日期：2016-09-01 00:00:00
abstract：:Calcification is the most characteristic pathologic feature of healed meconium peritonitis. Occurrence of calcification in meconium peritonitis has been reported, but its mechanism has not been discussed. According to our studies, the cause of calcification and giant cell reaction is meconium peritonitis is related to...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90062-8
更新日期：1984-05-01 00:00:00
abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.11.005
更新日期：2013-02-01 00:00:00
abstract：:Despite the widespread use of antidepressant medication, there are no signs that the burden of depression and suicide is decreasing in the industrialised world. This is generating mounting scepticism on the effectiveness of this class of drugs as an approach for the treatment of mood disorders. These doubts are also f...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2005.02.037
更新日期：2005-01-01 00:00:00
abstract：:Genetic and environmental influences are both known to be causal factors in the development and maintenance of obesity. Stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting increased glucocorticoid exposure are known to be important pathophysiological mechanisms in the deve...
journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2010.10.049
更新日期：2011-03-01 00:00:00
abstract：:Cancer pathologies are deeply associated with mitochondrial dysfunction. TFAM, transcription factor A of mitochondria plays eminent role in transcription and replication of mtDNA to synthesize different mitochondrial proteins, has been reported to have elevated levels during malignancy and can be a compelling target o...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.110075
更新日期：2020-10-01 00:00:00
abstract：:The hypothesis proposed in this article is that a haemodynamic mechanism may cause amyotrophic lateral sclerosis (ALS). The hypothesis is synthesized from three separate streams of medical research: (1) multiple sclerosis (MS) research; (2) ALS research; (3) atherosclerosis research. Each research stream was reviewed ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.03.017
更新日期：2010-10-01 00:00:00
abstract：:In the AKR strain of mice a high incidence of spontaneous lymphoid leukemia develops before 12 months of age. Genetic, viral, and endocrine factors interact during development to produce the syndrome. Many of the deficiencies of AKR mice are associated with gene action in chromosome 17, at or near the major histocompa...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(76)80005-9
更新日期：1976-11-01 00:00:00
abstract：:Yawning continues to pose as a scientist's conundrum. Evidence is presented of yawning and contagious yawning in a number of different neurological disorders. Explanations are discussed in the context of disparate neurological disorders together with proposals for how theses findings may be linked. Thus, greater under...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2010.08.002
更新日期：2010-12-01 00:00:00
abstract：:The hyponatremia found in multiple myeloma and which is associated with a reduced anion gap (ag) is considered to be pseudohyponatremia due to the displacement of water by the high globulin content in the blood. Serum proteins participate in acid-base balance. Stewart and other authors in their approach to acid-base i...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.02.051
更新日期：2006-01-01 00:00:00
abstract：:Acute carbon monoxide (CO) poisoning causes the neurologic symptoms and brain lesions during both acute and delayed phase. We propose that catecholamine crises in globus pallidus and deep white matter are the key pathophysiological factors causing acute and delayed brain injuries respectively. Increased sympathetic ac...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.04.032
更新日期：2014-08-01 00:00:00
abstract：:There are large amounts of zinc in muscle and zinc ions can enhance the degree of muscle contraction in response to direct stimulation while at the same time inhibiting neuromuscular transmission. The opposites of these effects would lead to myotonia and muscle weakness. There are many parallels between the non-muscul...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90052-3
更新日期：1980-04-01 00:00:00
abstract：:Emerging evidences indicate that elevated cholesterol and triglyceride levels precede Alzheimer's disease (AD) pathology. High caloric intake based on saturated fat raises hyperlipidaemia and also promotes AD pathology. As a result, strategy that limits the absorption of dietary fat and attenuates hyperlipidemia could...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.04.046
更新日期：2009-11-01 00:00:00
abstract：:The materno-fetal relationship is governed by critical levels of progesterone (P) and prostaglandin F2 alpha (PGF2 alpha). The 'see-saw' in concentration of these molecules maintain and terminate pregnancy in placental mammals. Apart from the enhancement or suppression of uterine contractility by PGF2 alpha and P resp...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(80)90021-3
更新日期：1980-10-01 00:00:00
abstract：:Whether retroviral integration is a phenomenon specific to properties of the surrounding genomic region is a widely debated question. In this paper we attempt to enlight the involvement of genomic regions prone to DNA double strand breaks in such process, as well as the more general concept of genome plasticity concer...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00410-3
更新日期：2003-02-01 00:00:00
abstract：:Tubulointerstitial fibrosis is a final common pathway to the eventual structural desolation of kidneys. However, the mechanism involved in this phenomenon is still poorly understood, and current therapies are ineffective or only marginally effective. Mast cell has a variety of physiological and pathological functions ...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.10.059
更新日期：2007-01-01 00:00:00
abstract：:TP53 (Tumor Protein 53, previously known as p53) is probably the best known of all tumor suppressor genes, and is mutated in nearly all (96%) high-grade serous ovarian cancer (HGS-OvCa), which is the most common histopathological type of epithelial ovarian cancer (EOC). Recently, TP53 is found to involve in regulating...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2013.06.009
更新日期：2013-10-01 00:00:00
abstract：:Cognitive plasticity, a developmental trait that promotes acquisition of complex skills such as language or playing musical instruments, diminishes substantially during puberty. The loss of plasticity has been attributed to surge of sex steroids during adolescence, but the phenomenon remains poorly understood. We hypo...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.07.027
更新日期：2004-01-01 00:00:00
