Abstract：
:ATP sensitive (K(+)(ATP)) potassium cardiac channels are recruited when ATP levels are low as in ischemic injury and acute trauma. Such activation results in ECG-ST elevation and cardiac arrhythmias. K(+)(ATP) channel recruitment may be blocked by the sulfonylurea glibenclamide, permitting a wide variety of animal experimentation designed to test the genesis of ECG-ST segment elevations and depressions in diverse conditions including digitalis effect, acute arterial occlusion, tachycardias, and acute pericarditis. A specific series of animal experiments designed to test this hypothesis is proposed. Clinical implications are discussed.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Hoffman I,Saltzman Bdoi
10.1016/s0306-9877(03)00055-0keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
593-7issue
4eissn
0306-9877issn
1532-2777pii
S0306987703000550journal_volume
60pub_type
杂志文章abstract：:Pulmonary hypertension (PH) is defined as elevated mean pulmonary artery pressure secondary to e.g. congenital heart disease and chronic obstructive pulmonary disease. It elevates right ventricular afterload that eventually leads to cor pulmonale and right heart failure. Experimental research has shown that cardioprot...
journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.008
更新日期：2013-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.10.010
更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.mehy.2012.05.025
更新日期：2012-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.01.032
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Medical hypotheses
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
