Abstract:
:An unexpected and novel finding is described and discussed here concerning the synaptic physiology of hippocampal slices during the period of recovery after brain dissection. Contrary to the common notion that the amplitude of synaptic responses recovers in a single exponential rising fashion, we found that synaptic response amplitude displayed an oscillatory pattern. The period of oscillation was of 6h and its frequency depended on the input frequency of stimulation. Based on these preliminary data we can make an assumption that the recovery-associated oscillatory behavior of synaptic responses may be hippocampus specific. These data suggest the existence of a previously undescribed element that modifies the electrical properties underlying the modulation of synaptic responses in a neuronal population. The article hypothesizes a mechanism for this phenomenon.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Gourov AVdoi
10.1016/j.mehy.2011.09.010subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1094-7issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(11)00463-4journal_volume
77pub_type
杂志文章abstract::The malignant melanoma may display extremely variable forms of development, from clinical forms with a lethal course to the unforeseeable situations of spontaneous cures. The basic immunotherapeutic procedures, as well as hypotheses regarding the mechanisms involved in courses towards spontaneous regressions, are pres...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90443-0
更新日期:1996-08-01 00:00:00
abstract::Antisense oligonucleotides (oligos) have demonstrated efficacy for the treatment of various cancers, infectious diseases and metabolic disorders. While most studies have utilized single oligos either administered alone, or more recently in combination therapy with other drugs, some investigators have administered more...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.12.032
更新日期:2005-01-01 00:00:00
abstract::Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's disease. Moreover, MAP ha...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.09.025
更新日期:2014-12-01 00:00:00
abstract::The incidence of breast cancer in women has increased dramatically over the last decade. Epidemiological markers of this increased incidence include: endocrine related phenomena (early menarche, age of first parity and age of menopause); exposure of the breast to X-radiation; and a group of seemingly disparate factors...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90090-y
更新日期:1992-07-01 00:00:00
abstract::Obesity is the second largest cause of preventable death in the United States. Historically, obesity was considered a behavioral problem that could be simply addressed with behavioral modifications in diet and exercise. As scientific advancements have demonstrated in other neurological healthcare conditions such as al...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.08.041
更新日期:2007-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organs involved. Kidney damage is common among SLE patients. In lupus nephritis, extracellular DNA accumulation from necrosis cells and activated cells is perceived as initial step of inflammation. The up-regulated type I IFN is one pivotal cyto...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.09.015
更新日期:2018-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.11.007
更新日期:2008-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00103-8
更新日期:2003-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.1999.0979
更新日期:2000-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109375
更新日期:2019-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90071-l
更新日期:1990-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00363-8
更新日期:2003-02-01 00:00:00
abstract::In the recent hypothesis that hair loss might be a manifestation of metabolic abnormalities particularly hyperglicemia. It has been reported various environmental risk factors affecting hair loss. There is growing evidence on the relationship between prediabetes and worse metabolic profile. However, there are few stud...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.09.014
更新日期:2012-12-01 00:00:00
abstract::Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90194-1
更新日期:1989-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 信件
doi:10.1016/j.mehy.2020.110046
更新日期:2020-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.10.006
更新日期:2012-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(79)90041-0
更新日期:1979-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90066-7
更新日期:1995-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.04.042
更新日期:2008-01-01 00:00:00
abstract::Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.04.039
更新日期:2011-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2003.12.059
更新日期:2005-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.02.051
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.11.006
更新日期:2011-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1089
更新日期:2000-12-01 00:00:00
abstract::Logic, a fundamental component of research in the exact sciences is often not applied in prominent fields of medical research. Investigation into the aetiopathogenesis of headache, vertigo, and fatigue--acknowledged as the commonest and amongst the most prominent and debilitating of symptoms known to mankind--may be s...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90025-a
更新日期:1990-04-01 00:00:00
abstract::It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant). Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00294-3
更新日期:2003-08-01 00:00:00
abstract::The hypothesis proposed in this article is that a haemodynamic mechanism may cause amyotrophic lateral sclerosis (ALS). The hypothesis is synthesized from three separate streams of medical research: (1) multiple sclerosis (MS) research; (2) ALS research; (3) atherosclerosis research. Each research stream was reviewed ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.03.017
更新日期:2010-10-01 00:00:00
abstract::The AIDS dementia complex and peripheral neuropathy in AIDS are considered to be direct or indirect manifestations of HIV infection, yet the pathogenesis in unclear. There are parallels between AIDS and Tangier disease clinically and histopathologically and in lipid metabolism. The neurological disorders in AIDS may b...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90085-s
更新日期:1990-09-01 00:00:00
abstract::High doses of oestrogens in the dog and ferret cause myeloid hyperplasia in the bone marrow superseded by hypoplasia affecting all cell lines. In the peripheral blood after an initial leucocytosis, there is thrombocytopenia, anaemia and leucopenia. These effects, which are ultimately lethal, do not occur in cats, rats...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90070-2
更新日期:1985-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(03)00072-0
更新日期:2003-06-01 00:00:00