Abstract：
:High fat and low carbohydrate diet, designated ketogenic diet, has been successfully used for the treatment of intractable epilepsy in a portion of patients, particularly in children. Several hypotheses have been worked out for the explanation of its beneficial effects, among others acetone has been raised as a causative factor. However, despite the endeavours the mode of action of the diet is still an enigma. And it is also not known why the diet is effective in some patients, while in others it is without any effect. Here a possible way for the effect of ketogenic diet is proposed in which the central point of seizure preventing effect of the diet is the metabolism of acetone. The proposal nominates S-D-lactoylglutathione, an intermediate of acetone metabolism, as a factor being responsible for seizure controlling effect of ketogenic diet and on the other hand, a sequence of evidence is given for the support of suggestion. S-D-lactoylglutathione would exert its effect by the influence of K(+) channels. The proposal also gives an explanation of why only a portion of patients benefit while on the diet. A proposition is also made for the future directions of research involving the measurement of intermediates of S-D-glutathione breakdown in the cerebrospinal fluid and clinical trials with selected groups of patients. The establishment of this specific mechanism for the ketogenic diet may lead to novel strategies for the investigation and the treatment of intractable epilepsies.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Kalapos MPdoi
10.1016/j.mehy.2006.10.041subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1382-8issue
6eissn
0306-9877issn
1532-2777pii
S0306-9877(06)00789-4journal_volume
68pub_type
杂志文章abstract：:Breast cancer associated with pregnancy is defined as the one in which the diagnosis is made in a pregnancy or within one year of delivery. Breast cancer is the second most common malignancy during pregnancy and it is generally considered to have a worse prognosis than the one that is not associated with pregnancy. Th...
journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.05.072
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(89)90105-9
更新日期：1989-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2008.07.028
更新日期：2008-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(84)90071-9
更新日期：1984-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,评审
doi：10.1016/j.mehy.2007.10.016
更新日期：2008-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00260-8
更新日期：2002-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2006.02.017
更新日期：2006-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109848
更新日期：2020-11-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.02.003
更新日期：2016-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2016.05.030
更新日期：2016-08-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 社论
doi：10.1016/j.mehy.2008.05.018
更新日期：2008-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(91)90008-m
更新日期：1991-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.1999.0943
更新日期：2000-05-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.09.044
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2012.12.016
更新日期：2013-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.10.042
更新日期：2012-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(86)90112-x
更新日期：1986-04-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2011.06.040
更新日期：2011-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2014.10.002
更新日期：2014-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1054/mehy.2001.1284
更新日期：2001-09-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.07.058
更新日期：2007-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/0306-9877(92)90057-j
更新日期：1992-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2009.08.027
更新日期：2010-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章,meta分析
doi：10.1016/s0306-9877(98)90047-0
更新日期：1998-10-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2004.10.013
更新日期：2005-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(02)00156-1
更新日期：2002-12-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2003.12.030
更新日期：2004-01-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/s0306-9877(98)90201-8
更新日期：1998-02-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2020.109614
更新日期：2020-06-01 00:00:00
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journal_title：Medical hypotheses
pub_type： 杂志文章
doi：10.1016/j.mehy.2006.08.041
更新日期：2007-01-01 00:00:00
