General principle of existence of natural objects.

abstract：:Recent investigations on protease inhibitors in articular cartilage have provided new insights into the possible initial lesions of osteoarthrosis. A hypothesis has been formulated based upon an impaired ability of chondrocytes to synthesize protease inhibitors, which leads to loss of matrix integrity and vascular inv...

journal_title：Medical hypotheses

authors： Stephens RW,Ghosh P,Taylor TK

更新日期：1979-07-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that the regular practice of mindfulness meditation is associated with increased physiological levels of melatonin. Melatonin may be related to a variety of biologic functions important in maintaining health and preventing disease, including breast and prostate ca...

journal_title：Medical hypotheses

authors： Massion AO,Teas J,Hebert JR,Wertheimer MD,Kabat-Zinn J

更新日期：1995-01-01 00:00:00

abstract：:Dementia and other causes of functional disability can create considerable burdens for families and society as a whole, but it may be possible to partially alleviate this strain through technical innovations that replace some functions of human caregivers. This article proposes the hypothesis that cell phones, interne...

journal_title：Medical hypotheses

authors： Alisky JM

更新日期：2006-01-01 00:00:00

abstract：:A neural network approach to modeling the development of personality traits through social learning is presented. From the more general model the special case of a network mapping four situation dimensions (input neurons) into seven dimensional personality traits (output neurons) is described. This network is allowed ...

journal_title：Medical hypotheses

authors： Gonzalez-Heydrich J

更新日期：1993-08-01 00:00:00

abstract：:The nasal mucosa is very vascular, receiving more blood flow per cubic centimeter of tissue than does muscle, brain or liver (Drettner and Aust, 1974; [1]). This vascularity can present a major problem during sinus surgery. Surgeons routinely use topical vasoconstrictors in endoscopic sinus surgery however, the optima...

journal_title：Medical hypotheses

authors： Campbell RG,Nair S,Sacks R,Douglas RG

更新日期：2014-06-01 00:00:00

abstract：:Autism continues to be a significant cause of psychosocial pathology in affected children and adults. Until recently, the predominant research thrust to uncover the cause of this condition has been the search for a major nuclear mutation. Although a small percentage of cases do demonstrate such a DNA fault, recent eff...

journal_title：Medical hypotheses

authors： Steinman G

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. ...

journal_title：Medical hypotheses

authors： Brenner SR

更新日期：2017-05-01 00:00:00

abstract：:It is suggested that chronic fatigue syndrome/fibromyalgia is caused by virus injury to the calcium channels leading to larger quantities than usual of calcium ions entering the striated muscle cells. Should this be true, then treatment with a calcium antagonist (CA) may possibly be of value. ...

journal_title：Medical hypotheses

authors： Lund-Olesen LH,Lund-Olesen K

更新日期：1994-07-01 00:00:00

abstract：:Neurodegenerative diseases are associated with neuronal inclusions, comprised of protein aggregates. In Alzheimer's Disease (AD) and Lewy Body Disease (LBD) such lesions are distributed in a hierarchical retrograde transynaptic spatial pattern. This implies a retrograde transynaptic temporal propagation as well. There...

journal_title：Medical hypotheses

authors： Royall DR

更新日期：2013-02-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a severe, occlusive, thrombotic microangiopathy characterized by a systemic platelet aggregation, organ ischemia, profound thrombocytopenia and erythrocyte fragmentation. Recent observations have documented that a deficiency of a von Willebrand factor (VWF)-cleaving proteas...

journal_title：Medical hypotheses

authors： Franchini M

更新日期：2005-01-01 00:00:00

abstract：:Epidemiologic literatures suggest that temporomandibular joint disorders (TMD) are more prevalent in women than in men. It is affecting approximately 7-15% of the adult population in North America, and 80% of patients treated for TMD are women. The severity of symptoms is also related to the age of the patients. The g...

journal_title：Medical hypotheses

authors： Wang J,Chao Y,Wan Q,Zhu Z

更新日期：2008-10-01 00:00:00

abstract：:The U.S. Environmental Protection Agency's (EPA) proposed drinking water standard for radium-226 (226Ra) of 5 pCi/l is evaluated according to its health basis and carcinogenic implications. Proposed health risks of 226Ra in drinking water by other leading theoreticians (Evans, Gofman-Tamplin and Peterson) are also con...

journal_title：Medical hypotheses

authors： Riddiough CR,Musselman R,Calabrese EJ

更新日期：1977-09-01 00:00:00

abstract：:Recent findings indicate a principal role for Hepcidin in iron homeostasis. Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease. Under normal conditions influx and efflux of iron from duodenal enterocytes is regulated by Ferroportin. Fer...

journal_title：Medical hypotheses

authors： Arnold J,Sangwaiya A,Bhatkal B,Arnold A

更新日期：2008-01-01 00:00:00

abstract：:The biophysical processes during electroconvulsive therapy (ECT) are discussed. The multilayer head structure causes a shunting and spreading of the major portions of the current all over the extracranial tissues. The final effect is that only a small percentage of the injected current passes into the brain. The secon...

journal_title：Medical hypotheses

authors： Zyss T

更新日期：1994-08-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 is causally associated with a subset of oral cancers, predominantly those cancers arising in the oropharynx (OP). Increased HPV16 E6 and E7 oncogene expressions are responsible for the malignant transmission in these cancers. ErbB-2 is the family member most closely implicated in hum...

journal_title：Medical hypotheses

authors： Altundag O,Altundag K,Morandi P,Gunduz M

更新日期：2004-01-01 00:00:00

abstract：:A steady fall in mortality rates from cardiovascular diseases (CVD) has been reported recently in the United States. This study tests the hypothesis that fruits and vegetables had a protective effect against cardiovascular mortality among the American population from 1964-78. Special attention was focused on more spec...

journal_title：Medical hypotheses

authors： Verlangieri AJ,Kapeghian JC,el-Dean S,Bush M

更新日期：1985-01-01 00:00:00

abstract：:On the nature of wellness, stress, netting and the radical gas nitric oxide (NO). The multi-complex role of NO resulted in its discoverers receiving a Nobel award, its presence everywhere and volatility makes it a suitable candidate to be a main signal in an instantaneous communication network. Such network, with the ...

journal_title：Medical hypotheses

authors： Ralt D

更新日期：2008-01-01 00:00:00

abstract：:The hypterphosphorylation of tau proteins is a well-established step in the expression of the pathological features in Alzheimer's disease (AD). While a primary event that links aluminum and AD, the so-called 'aluminum hypotheses', is far from being demonstrated, however, the metal ion could be an important etiologica...

journal_title：Medical hypotheses

authors： Zatta PF

更新日期：1995-03-01 00:00:00

abstract：:Recurrent aphthous ulcer (RAU) is the most common ulcer of oral non-keratinized mucosa, but the treatment is always limited at present. Considering the multifactorial etiology of RAU, a novel therapeutic agent with multi-bioactivties should be presented. Garlic has been recognized as a favorable natural medicine again...

journal_title：Medical hypotheses

authors： Jiang XW,Hu J,Mian FI

更新日期：2008-12-01 00:00:00

abstract：:Computer algorithms can only produce seemingly random or pseudorandom numbers whereas certain natural phenomena, such as the decay of radioactive particles, can be utilized to produce truly random numbers. In this study, the ability of humans to generate random numbers was tested in healthy adults. Subjects were simpl...

journal_title：Medical hypotheses

authors： Persaud N

更新日期：2005-01-01 00:00:00

abstract：:Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. ...

journal_title：Medical hypotheses

authors： Farhadi P,Yarani R,Kiani S,Mansouri K

更新日期：2021-01-01 00:00:00

abstract：:A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allo...

journal_title：Medical hypotheses

authors： Łuczkiewicz P,Daszkiewicz K,Chróścielewski J,Witkowski W,Kuik L

更新日期：2017-04-01 00:00:00

abstract：:There are many observations regarding the behaviour of melanoma which points away from sunshine as the main cause of this tumour. Incidence data shows that the increase is mostly seen for thin melanomas which cannot be attributed to sun exposure but increasing screening over the last 20 years. Melanoma behaves in a si...

journal_title：Medical hypotheses

authors： Bataille V

更新日期：2013-11-01 00:00:00

abstract：:Exercise is thought to have considerable potential as a preventive for osteoporosis. We critically examined 27 studies that address the prophylactic role of exercise in osteoporosis. The results from both cross-sectional and longitudinal studies showed that differences in bone mass were more pronounced in the axial sk...

journal_title：Medical hypotheses

authors： Block JE,Smith R,Friedlander A,Genant HK

更新日期：1989-09-01 00:00:00

abstract：:So-called 'limited life span' of diploid cells does not depend on their unresponsiveness to growth factors from the data obtained by complete protein-free culture of tumor cells. Limited proliferation (called limited life span) of diploid cells is one of the 'ad-hoc' negative regulatory mechanisms in animals, and can ...

journal_title：Medical hypotheses

authors： Chigira M,Watanabe H

更新日期：1993-10-01 00:00:00

abstract：:Class II malocclusion is one of the most common orthodontic problems. The main aetiology of Class II malocclusion is mandibular retrognathia. A variety of functional appliances have been used to stimulate mandibular growth in adolescence, however, the effects remain unsatisfactory. Therefore, new approaches are in nee...

journal_title：Medical hypotheses

authors： Li Y,Yang P,Fan X,Wang J,Liu J,Zhao Z,Zhao M

更新日期：2009-03-01 00:00:00

abstract：:Regulation of ion transport across the airway mucosa may be involved in the mechanisms producing hyperreactivity and asthma. Atrial Natriuretic Peptide (ANP) has been proposed to participate in the pathogenesis of asthma, and it has been found to have a bronchodilatory effect on asthmatic patients. Experimental eviden...

journal_title：Medical hypotheses

authors： Almirall JJ,Hedenstierna G

更新日期：1991-09-01 00:00:00

abstract：:Exercise induced bronchospasm (EIB) affects approximately 10% of normal individuals with higher prevalence rates among children, obese adults, and competitive athletes. Although hyperpnea with dry air is the best known cause, the problem is multifactorial with atopy, asthma and chlorine all playing established roles. ...

journal_title：Medical hypotheses

authors： Simkin PA,Snitily BK

更新日期：2015-11-01 00:00:00

abstract：:In this paper it is proposed to extend the classical models of sleepiness in two ways. Firstly, the role of a wake drive, besides a sleep drive, in determining sleepiness is emphasised. Although this has already been suggested in literature and convincing arguments can be found, it is not generally accepted. Secondly,...

journal_title：Medical hypotheses

authors： De Valck E,Cluydts R

更新日期：2003-04-01 00:00:00

abstract：:Corona virus disease 2019 (Covid-19), a pandemia emerged recently, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The receptor for corona virus and influenza A is the mucosal cell membrane protein angiotensin converting enzyme 2 (ACE2), which is abundant on the membrane of alveolar cells and ...

journal_title：Medical hypotheses

authors： Niv Y

更新日期：2020-10-01 00:00:00