Sleepiness as a state-trait phenomenon, comprising both a sleep drive and a wake drive.

Abstract:

:In this paper it is proposed to extend the classical models of sleepiness in two ways. Firstly, the role of a wake drive, besides a sleep drive, in determining sleepiness is emphasised. Although this has already been suggested in literature and convincing arguments can be found, it is not generally accepted. Secondly, we argue to incorporate trait aspects of sleepiness or a long-term person-specific level of sleepiness, besides short-term changes of sleepiness or 'state-sleepiness'. Shortly, a conceptualisation of sleepiness in which situational wake drive and sleep drive modify a basal level of both wake drive and sleep drive, is proposed. It implies that sleepiness can result from essentially different factors involved: a chronic condition or an acute state of either a high level of sleep drive, a low level of arousal or a combination of both. This is illustrated in a working model and potential assessment tools for the wake drive and state versus trait sleepiness are discussed.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

De Valck E,Cluydts R

doi

10.1016/s0306-9877(02)00444-9

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

509-12

issue

4

eissn

0306-9877

issn

1532-2777

pii

S0306987702004449

journal_volume

60

pub_type

杂志文章
  • Peripheral arterial disease: a manifestation of evolutionary dislocation and feed-forward dysfunction.

    abstract::Peripheral arterial disease in the legs represents a subset of atherosclerosis that manifests a particularly sinister profile. A predominance of sympathetic activity in the periphery favors the development of neurogenic atherosclerosis. Atherosclerosis may then produce flow derangements and decreased physical activity...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.03.027

    authors: Simpson JD,Doux JD,Lee PY,Yun AJ

    更新日期:2006-01-01 00:00:00

  • Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19?

    abstract::Toll-like receptor 7 is critical in recognition of single strand RNA viruses, including SARS CoV-2, and generation of anti-viral immunity. Coronaviruses evolved strategies to dampen the host immunity. Herein, we discuss the potential use of TLR7 agonists in the early stages of COVID-19 treatment. ...

    journal_title:Medical hypotheses

    pub_type: 信件

    doi:10.1016/j.mehy.2020.110202

    authors: Avcilar H,Eken A

    更新日期:2020-11-01 00:00:00

  • Synaptic instability in a neuronal population as an element of encoding information.

    abstract::An unexpected and novel finding is described and discussed here concerning the synaptic physiology of hippocampal slices during the period of recovery after brain dissection. Contrary to the common notion that the amplitude of synaptic responses recovers in a single exponential rising fashion, we found that synaptic r...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2011.09.010

    authors: Gourov AV

    更新日期:2011-12-01 00:00:00

  • Edaravone: a new therapeutic approach for the treatment of acute stroke.

    abstract::Acute stroke, including acute ischemic stroke (AIS) and acute hemorrhagic stroke, (AHS) is a common medical problem with particular relevance to the demographic changes in industrialized societies. In recent years, treatments for AIS have emerged, including thrombolysis with tissue plasminogen activator (t-PA). Althou...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.07.038

    authors: Kikuchi K,Kawahara K,Miyagi N,Uchikado H,Kuramoto T,Morimoto Y,Tancharoen S,Miura N,Takenouchi K,Oyama Y,Shrestha B,Matsuda F,Yoshida Y,Arimura S,Mera K,Tada K,Yoshinaga N,Maenosono R,Ohno Y,Hashiguchi T,Maruyama

    更新日期:2010-12-01 00:00:00

  • Nutraceutical strategies for ameliorating the toxic effects of alcohol.

    abstract::Rodent studies reveal that oxidative stress, much of it generated via induction/activation of NADPH oxidase, is a key mediator of a number of the pathogenic effects of chronic ethanol overconsumption. The highly reactive ethanol metabolite acetaldehyde is a key driver of this oxidative stress, and doubtless works in o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2012.12.040

    authors: McCarty MF

    更新日期:2013-04-01 00:00:00

  • Is there a role for lymph in intestinal glucose absorption?

    abstract::Although the role of the lymphatic circulation in the uptake of dietary fat is well established, the absorption of water-soluble compounds, secreted by the enterocyte into the lymph, has received little attention. In the present study an estimate is made of the amount of dietary glucose that can be absorbed via the ly...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(90)90169-f

    authors: Argilés JM,Fernández-López JA,Casado J,Alemany M

    更新日期:1990-11-01 00:00:00

  • Biophysical body-brain-mind unity: theory and practice.

    abstract::A novel substance-attributed biophysical theory of brain-mind unity is presented. We separate spiritualism and matters of the soul from the medical sphere. Biophysical principles are responsible for the body's operational regimen (BOR) in the homeostatic state which allows for materialization and emergence of the mind...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.1999.0852

    authors: Naisberg Y

    更新日期:2000-03-01 00:00:00

  • A new concept of renal hemodynamics.

    abstract::Observations which show that urine output can vary with changes in the contour of the pulse cure, that it can even increase while the mean blood pressure falls during counterpulsation, that the well known hypertensive effect of a renal artery stenosis can also be produced by an aneurysm of the renal artery, cannot be ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(78)90004-x

    authors: Gatzek WJ

    更新日期:1978-05-01 00:00:00

  • Sulfite oxidase deficiency: a high risk factor in SO2, sulfite, and bisulfite toxicity?

    abstract::It has been hypothesized that sulfite oxidase deficient persons may be at increased risk to toxicity from SO2 and dietary sulfites widely used for food preservation. Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion. Human and animal studies have shown ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(81)90110-9

    authors: Calabrese E,Sacco C,Moore G,DiNardi S

    更新日期:1981-02-01 00:00:00

  • Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome.

    abstract:BACKGROUND:Somatization is a multisomatoform disorder characterized by medically unexplained, functional or psychosomatic symptoms. Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS:This paper reviews the evidence that such symptoms are o...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/j.mehy.2012.02.023

    authors: Anderson G,Maes M,Berk M

    更新日期:2012-06-01 00:00:00

  • Biophotons, microtubules and CNS, is our brain a "holographic computer"?

    abstract::Several experiments show that there is a cell to cell communication by light in different cell types. This article describes theoretical mechanisms and subcellular structures that could be involved in this phenomenon. Special consideration is given to the nervous system, since it would have excellent conditions for su...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/S0306-9877(03)00308-6

    authors: Grass F,Klima H,Kasper S

    更新日期:2004-01-01 00:00:00

  • gamma-Glutamyltransferase is a promising biomarker for cardiovascular risk.

    abstract::Oxidative stress plays a crucial role in a variety of clinical settings of atherogenesis, and mediates many pathways linked to atherosclerosis and inflammation. gamma-Glutamyltransferase (GGT), an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis an...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审

    doi:10.1016/j.mehy.2006.04.010

    authors: Turgut O,Yilmaz A,Yalta K,Karadas F,Birhan Yilmaz M

    更新日期:2006-01-01 00:00:00

  • The suppression of endogenous adrenalin in the prolongation of ketamine anesthesia.

    abstract::This study investigated whether or not the anesthetic effect of ketamine in rats is dependent on adrenal gland hormones. The study was performed on two main rat groups, intact and adrenalectomized. Rat were divided into subgroups and given appropriate doses of ketamine, metyrapone or metyrosine. Durations of anesthesi...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2014.03.033

    authors: Aksoy M,Ince I,Ahiskalioglu A,Dostbil A,Celik M,Turan MI,Cetin N,Suleyman B,Alp HH,Suleyman H

    更新日期:2014-07-01 00:00:00

  • Keloid and hypertrophic scar: neurogenic inflammation hypotheses.

    abstract::The mechanisms of fibroproliferation disease (FPD) of the skin, such as keloids and hypertrophic scars, are still unknown. Since mechanical stress appears to be an important factor for FPD generation, we have studied the intervening factors that connect mechanical stress with keloid and scar formation. Hence, we intro...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2008.01.032

    authors: Akaishi S,Ogawa R,Hyakusoku H

    更新日期:2008-01-01 00:00:00

  • Mosaic aging.

    abstract::Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.12.031

    authors: Walker LC,Herndon JG

    更新日期:2010-06-01 00:00:00

  • Neuropharmacologic control of cerebral capillary permeability: current implications for therapy of vasogenic brain edema.

    abstract::Vasogenic brain edema occurs as a result of a diverse spectrum of central nervous system pathology. The fundamental physiologic abnormality of vasogenic brain edema is an increase in cerebral capillary permeability. It is hypothesized that the recent development of new, potent, synthetic vasopressin antagonists will m...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(88)90112-0

    authors: Weinand ME

    更新日期:1988-05-01 00:00:00

  • Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 d

    abstract::The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to car...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2019.02.027

    authors: Sjöblad S

    更新日期:2019-04-01 00:00:00

  • Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?

    abstract::SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatm...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109843

    authors: Abeygunasekera A,Jayasinghe S

    更新日期:2020-10-01 00:00:00

  • Three-dimensional spring model: a new hypothesis of pathogenesis of adolescent idiopathic scoliosis.

    abstract::The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2009.02.046

    authors: Yang Z,Xie Y,Li M

    更新日期:2009-11-01 00:00:00

  • Hv1 proton channel possibly promotes atherosclerosis by regulating reactive oxygen species production.

    abstract::Atherosclerosis and its fatal complications, such as myocardial infarction or stroke, represent the most common cause of morbidity or mortality in modern world. It was observed that an excess of reactive oxygen species (ROS) accompanies atherosclerosis. Under physiological circumstances, intracellular H+ accumulates a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.109724

    authors: Zheng Z,Zhang Z,Wang M

    更新日期:2020-08-01 00:00:00

  • The hyponatramia of multiple myeloma is true and not pseudohyponatramia.

    abstract::The hyponatremia found in multiple myeloma and which is associated with a reduced anion gap (ag) is considered to be pseudohyponatremia due to the displacement of water by the high globulin content in the blood. Serum proteins participate in acid-base balance. Stewart and other authors in their approach to acid-base i...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.02.051

    authors: Sachs J,Fredman B

    更新日期:2006-01-01 00:00:00

  • Potential human health risks associated with animal retroviruses: some hypotheses.

    abstract::Several studies have demonstrated the existence of morphological, biological, genetic and antigenic correlations between human and animal retroviruses. Furthermore, some agents of bovine and feline origin can also be considered useful comparative models for the pathogenetic study of human diseases such as leukaemia, a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(89)90194-1

    authors: Di Guardo G

    更新日期:1989-07-01 00:00:00

  • Intra-monocyte pathogens delineate autism subgroups.

    abstract::Immune panels of many autism-spectrum children reveal signs of atypical infections and shifted cell counts. In conjunction with trait-related cerebral hypometabolism and hypoperfusion, these findings suggest a hypothesis: Several autism-spectrum subgroups derive from intra-monocyte pathogens such as measles virus, cyt...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2000.1247

    authors: Binstock T

    更新日期:2001-04-01 00:00:00

  • Is EPA's radium-226 drinking water standard justified?

    abstract::The U.S. Environmental Protection Agency's (EPA) proposed drinking water standard for radium-226 (226Ra) of 5 pCi/l is evaluated according to its health basis and carcinogenic implications. Proposed health risks of 226Ra in drinking water by other leading theoreticians (Evans, Gofman-Tamplin and Peterson) are also con...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(77)90002-0

    authors: Riddiough CR,Musselman R,Calabrese EJ

    更新日期:1977-09-01 00:00:00

  • The dawn of the yawn: is yawning a warning? Linking neurological disorders.

    abstract::Yawning continues to pose as a scientist's conundrum. Evidence is presented of yawning and contagious yawning in a number of different neurological disorders. Explanations are discussed in the context of disparate neurological disorders together with proposals for how theses findings may be linked. Thus, greater under...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2010.08.002

    authors: Thompson SB

    更新日期:2010-12-01 00:00:00

  • Night terrors and sudden unexplained nocturnal death.

    abstract::A high incidence of sudden unexplained nocturnal deaths has been reported among young Asian males. These deaths are known as Pokkuri in Japan, Bangungut in the Philippines and Sudden Unexplained Nocturnal Death in the United States. Post mortem analysis has demonstrated cardiac conduction defects in many of the victim...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/0306-9877(88)90071-0

    authors: Melles RB,Katz B

    更新日期:1988-06-01 00:00:00

  • Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.

    abstract::Essential hypertension is a heterogeneous multifactorial syndrome associated with a high cardiovascular risk. A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2006.07.058

    authors: Ferrari P,Ferrandi M,Valentini G,Manunta P,Bianchi G

    更新日期:2007-01-01 00:00:00

  • L-Homoserine: a novel excreted metabolic marker of hepatitis B abnormally produced in liver from methionine.

    abstract::The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid L-homoserine is a patho...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1054/mehy.2001.1527

    authors: Gazarian KG,Gening LV,Gazarian TG

    更新日期:2002-04-01 00:00:00

  • Washing hands and the face may reduce COVID-19 infection.

    abstract::The contribution of various modes of transmission of SARS-CoV-2 has been the subject of recent intensive debate. The predominant route of the viral transmission is via exhaled droplets of different sizes which can be inhaled by nearby exposed individuals or deposited on peoples and surfaces. Touching contaminated surf...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2020.110261

    authors: Przekwas A,Chen Z

    更新日期:2020-11-01 00:00:00

  • Carbon dioxide therapy in hypocapnic respiratory failure.

    abstract::Oxygen therapy, usually administered by a facemask or nasal cannulae, is the current default treatment of respiratory failure. Since respiration entails intake of oxygen and release of carbon dioxide from tissues as waste product, the notion of administering carbon dioxide in respiratory failure appears counter-intuit...

    journal_title:Medical hypotheses

    pub_type: 杂志文章

    doi:10.1016/j.mehy.2017.11.010

    authors: Julu POO,Shah M,Monro JA,Puri BK

    更新日期:2018-01-01 00:00:00