Induction of a local pseudo-pregnancy for the treatment of endometriosis.

Abstract:

:As a common cause of chronic pelvic pain, endometriosis affects 10% of women of reproductive age. The most popular strategy for treating endometriosis is pseudo-pregnancy therapy. However, the efficacy of common systemic pseudo-pregnancy therapy is significantly attenuated by poor compliance because of so many side effects. While levonorgestrel-releasing intrauterine systems (LNG-IUS) successfully localize the effect of pseudo-pregnancy to the genital tract in treating endometriosis, it seemed to be insufficient to suppress the ovarian and extragenital endometriosis. We postulate that induction of a local pseudo-pregnancy via progestogen-loaded microsphere in the lesions of endometriosis may provide a more effective treatment with fewer side effects.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Yuan P,Huang Y,Cheng B,Zhang J,Xin X

doi

10.1016/j.mehy.2009.08.001

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

56-8

issue

1

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(09)00550-7

journal_volume

74

pub_type

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