Abstract:
:Myocardial ischemia/reperfusion injury (I/RI) is the principal cause of mortality and morbidity in diabetic patients undergoing cardiac surgery. However, there is no specific measure available to protect diabetic hearts in this clinical setting. Our clinical studies showed that adenosine pre-treatment or post-treatment and adding adenosine to cardioplegia solution had significant myocardial protective effects in patients undergoing cardiac surgery. However, the specific protective effects and mechanisms of adenosine in diabetic myocardial I/RI are not clear. Calpain is an important proteolytic enzyme in the myocardium. Studies show that the activation of calpain is an injury factor in not only the diabetic myocardium but also myocardial I/RI progression. We therefore hypothesize that adenosine play a protective role in diabetic myocardial I/RI through the inhibition of calpain.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Yang Y,Duan W,Zhou J,Yan J,Liu J,Zhang J,Jin Z,Yi Ddoi
10.1016/j.mehy.2012.06.022subject
Has Abstractpub_date
2012-10-01 00:00:00pages
462-4issue
4eissn
0306-9877issn
1532-2777pii
S0306-9877(12)00298-8journal_volume
79pub_type
杂志文章abstract::The terminology of cerebellar ataxias encompasses a variety of sporadic and inherited debilitating diseases. Patients exhibit disabling deficits such as dysmetria, kinetic tremor and ataxia of stance/gait. We are currently lacking effective treatments in degenerative cerebellar ataxias. Animal models of cerebellar dis...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.01.009
更新日期:2008-01-01 00:00:00
abstract::Recently, a theory has been postulated that suggests that vital enzymes in ingested food interact synergistically with enzymes within the human body and more specifically with enzymes in the digestive tract. Alterations in food enzymes induced by bulk processing including heating and irradiation and also the addition ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90152-x
更新日期:1994-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(97)90305-4
更新日期:1997-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2016.06.012
更新日期:2016-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90144-9
更新日期:1994-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2011.07.030
更新日期:2011-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.07.021
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Medical hypotheses
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更新日期:2020-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.01.026
更新日期:2005-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00213-x
更新日期:2002-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1985-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.12.030
更新日期:2010-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(98)90025-1
更新日期:1998-03-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.04.003
更新日期:2010-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.12.052
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.08.027
更新日期:2010-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2001.1336
更新日期:2001-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.07.030
更新日期:2006-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1980-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1983-11-01 00:00:00