A novel hypothesis of atherosclerosis: EPCs-mediated repair-to-injury.

abstract：:Inotropic treatment remains the cornerstone for cardiogenic shock, an emergency that requires immediate resuscitative therapy before shock irreversibly damages vital organs. Although the sympathomimetic drug dobutamine is the most widely-used inotropic drug worldwide, it has several side effects including sinus tachyc...

journal_title：Medical hypotheses

authors： Roubille F,Lattuca B,Busseuil D,Leclercq F,Davy JM,Rhéaume E,Tardif JC

更新日期：2013-08-01 00:00:00

abstract：:Lack of vascularization results in increased demand for oxygen and creates a defined feature of the tumor microenvironment known as tumor hypoxia. It is well established that in response to hypoxia, hypoxia-inducible factor-1 α (HIF-1α) is induced which is an important factor in angiogenesis, invasion and metastasis. ...

journal_title：Medical hypotheses

authors： Farhadi P,Yarani R,Kiani S,Mansouri K

更新日期：2021-01-01 00:00:00

abstract：:Three important issues must be addressed in any attempt to determine whether combination painkillers play a role in analgesic nephropathy. The first issue, namely that of a causal link between the combination itself and nephrotoxicity, has never been adequately documented. On the contrary, there is much evidence that ...

journal_title：Medical hypotheses

authors： Driesens F,Awouters F,Goossens T,Janssen P

更新日期：1993-01-01 00:00:00

abstract：:For diagnosis of Human Immunodeficiency Virus (HIV) infection by the recently developed Polymerase Chain Reaction (PCR), the two commonly used clinical samples are either the peripheral blood monocytes (PBMC) or the plasma of the infected individuals. In the former instance, DNA is extracted from PBMC. The integrated ...

journal_title：Medical hypotheses

authors： Nandi J,Banerjee K

更新日期：1993-01-01 00:00:00

abstract：:Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis ...

journal_title：Medical hypotheses

authors： Sarode GS,Sarode SC,Tupkari JV,Deshmukh R,Patil S

更新日期：2016-08-01 00:00:00

abstract：:Goldberger discovered human pellagra was a non-infectious disease, affecting mostly the small and the timid in overcrowded institutions. Symptoms were diarrhoea, dermatitis and dementia. The staff and older children escaped the disease. They ate the meat and left the small and timid with the gravy. The 'Goldberger syn...

journal_title：Medical hypotheses

authors： Reid G

更新日期：1993-05-01 00:00:00

abstract：:Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manu...

journal_title：Medical hypotheses

authors： Greenspan HC

更新日期：1993-02-01 00:00:00

abstract：:The present paper hypothesizes that the top positions in academic medicine are generally occupied by less talented and skilled physicians who find more time to spare for administrative activities as compared to physicians who are successful in their research projects or enjoy their skills as practicing clinicians. A p...

journal_title：Medical hypotheses

authors： Sonnenberg A

更新日期：2007-01-01 00:00:00

abstract：:Fulminant hepatitis is associated with an 80% mortality rate. Surviving patients do not develop chronic liver disease. Failure to produce adequate amounts of interferon and to achieve an antiviral state seem to be the basic defects in this condition. Tumor necrosis factor (TNF) has been shown to be induced by viruses....

journal_title：Medical hypotheses

authors： Aderka D,Levo Y

更新日期：1988-11-01 00:00:00

abstract：:Muscle spindles are increasingly recognized as playing a pivotal role in the cause of dystonia. This development and own laryngeal observations that support the idea of causally "well-intentioned" stuttering motivated us to present the following hypothesis: stuttering events compensate for a sensory problem that arise...

journal_title：Medical hypotheses

authors： Schuster SH,Schuster FM

更新日期：2012-07-01 00:00:00

abstract：:Antidepressants, including tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors and serotonin-noradrenalin reuptake inhibitors, are the main biological treatment for major depression. However, not all depressed patients improve clinically despite appropriate treatment. Thus,...

journal_title：Medical hypotheses

authors： Tsai SJ

更新日期：2006-01-01 00:00:00

abstract：:A mechanism is proposed for the formation of Ebg-evolved beta galactosidase-of E. coli based on the following assumptions: 1. In the presence of lactose, certain proteins being translated bind to their m-RNA-ribosome complexes; 2. This binding interferes with the release of m-RNA from the bacterial chromosome, marking...

journal_title：Medical hypotheses

authors： Erhan S

更新日期：1979-11-01 00:00:00

abstract：:In early 2012 deaths (all-cause mortality) in England and Wales showed an unexpected and unexplained increase which continued for 18 months before abating. The highest percentage increase in deaths was noted to be for neurological degenerations (mainly dementia, Alzheimer's, Parkinson's). This study seeks to understan...

journal_title：Medical hypotheses

authors： Jones RP,Goldeck D

更新日期：2014-07-01 00:00:00

abstract：:Cameron and Pauling have reported large survival increases in terminal cancer patients treated with Vitamin C. Their trials, which have been criticised because not based on random, double-blind principles, are reviewed here using a broad inductive method that relies on diverse data of varying quality. Conclusions are ...

journal_title：Medical hypotheses

authors： Jaffey M

更新日期：1982-01-01 00:00:00

abstract：:Physiological levels of estrogen would seem to have a possible protective effect on hearing function and estrogen replacement therapy may delay hearing loss in menopausal women. Treatment of healthy menopausal women with Tibolone for 6 months resulted in improvement in audiometry results at low frequencies which was m...

journal_title：Medical hypotheses

authors： Köşüş N,Köşüş A,Turhan NÖ

更新日期：2011-03-01 00:00:00

abstract：:As human society is mainly cooperative, it is not clear how antisocial personality disorder (APD) persists. The current explanation is that sociopaths are cheaters who maximize their fitness by taking advantages from others. Although this argument is valid, we show here that society also benefits from APD. We propose ...

journal_title：Medical hypotheses

authors： Miric D,Hallet-Mathieu AM,Amar G

更新日期：2005-01-01 00:00:00

abstract：:Dental tissues contains stem cells or progenitors that have high proliferative capacity, are clonogenic in vitro and demonstrate the ability to differentiate to multiple type cells involving neurons, bone, cartilage, fat and smooth muscle. Numerous experiments have demonstrated that the multipotent stem cells are not ...

journal_title：Medical hypotheses

authors： Xin LZ,Govindasamy V,Musa S,Abu Kasim NH

更新日期：2013-10-01 00:00:00

abstract：:Circulating tumor cells (CTCs) have the potential to provide a surrogate for "real-time biopsy" of tumor biological activity. Enumeration and molecular characterization of CTCs in pancreatic cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy b...

journal_title：Medical hypotheses

authors： Ren C,Chen H,Han C,Jin G,Wang D,Wang D,Tang D

更新日期：2013-06-01 00:00:00

abstract：:Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...

journal_title：Medical hypotheses

authors： Wrightham MN,Cann AJ,Sewell HF

更新日期：1992-07-01 00:00:00

abstract：:Although membrane sphingomyelin (SPH) serves as the precursor for many signaling molecules, its presence in large amounts, and its specific localization in the outer monolayer of the plasma membrane suggest that it may have a cytoprotective function. We propose that SPH helps maintain the integrity of the plasma membr...

journal_title：Medical hypotheses

authors： Subbaiah PV,Sargis RM

更新日期：2001-08-01 00:00:00

abstract：:The hypterphosphorylation of tau proteins is a well-established step in the expression of the pathological features in Alzheimer's disease (AD). While a primary event that links aluminum and AD, the so-called 'aluminum hypotheses', is far from being demonstrated, however, the metal ion could be an important etiologica...

journal_title：Medical hypotheses

authors： Zatta PF

更新日期：1995-03-01 00:00:00

abstract：:Delayed healing and nonunions of bone fracture are critical problems in orthopedic surgery. Electrical stimulation has been used as a therapeutic method for enhancing bone healing for a long time. Despite unanimous clinical success, the underlying mechanism concerning bone tissue in response to electrical stimulation ...

journal_title：Medical hypotheses

authors： Huang CP,Chen XM,Chen ZQ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Eelier studies demonstrated the up-regulation of some transcriptional factors such as Oct4, Nanog, Sox2 in undifferentiated cancer cells. These transcriptional regulators are up-regulated in pluripotent cells, as well and are responsible for cell reprogramming in normal cells. It might be said that normal ce...

journal_title：Medical hypotheses

authors： Tavakol S

更新日期：2014-12-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) have traditionally been attributed to atherosclerosis, although there is increasing epidemiological, biochemical and genetic evidence that aneurysmal arterial disease is different from occlusive atherosclerosis. One of the most consistent biochemical findings in the aneurysmal aorta i...

journal_title：Medical hypotheses

authors： Norman PE,Wysocki SJ,Lamawansa MD

更新日期：1995-07-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) serum levels in man have long been utilized as a tumor marker and as a birth defect screening agent in the clinical laboratory. Although the physiological role of AFP has remained obscure, the stereotypic carrier/transport function of a fetal counterpart to albumin has been attributed to this o...

journal_title：Medical hypotheses

authors： Dauphinée MJ,Mizejewski GJ

更新日期：2002-06-01 00:00:00

abstract：:Obesity is a major public health problem, which occurs in epidemic proportions. Our understanding of the systems of the brain related to energy balance has increased over the last decade. As a result, drugs most commonly used today in the management of obesity have their primary effect in modulating the balance betwee...

journal_title：Medical hypotheses

authors： Rosmond R

更新日期：2004-01-01 00:00:00

abstract：:Although all multicellular organisms undergo structural and functional deterioration with age, senescence is not a uniform process. Rather, each organism experiences a constellation of changes that reflect the heterogeneous effects of age on molecules, cells, organs and systems, an idiosyncratic pattern that we refer ...

journal_title：Medical hypotheses

authors： Walker LC,Herndon JG

更新日期：2010-06-01 00:00:00

abstract：:Over the past decade evidence from multiple research trajectories have converged to provide evidence that impaired glucose metabolism and mitochondrial dysfunction in the brain are the critical issues laying at the root of Bipolar Disorder (BD). These developments have been paralleled by increasing recognition of the ...

journal_title：Medical hypotheses

authors： Campbell I,Campbell H

更新日期：2020-12-01 00:00:00

abstract：:No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properti...

journal_title：Medical hypotheses

authors： Warner TF,Azen EA

更新日期：1988-06-01 00:00:00

abstract：:It has been speculated that the rise of the adaptive immune system in jawed vertebrates some 400 million years ago gave them a superior protection to detect and defend against pathogens that became more elusive and/or virulent to the host that had only innate immune system. First, this line of thought implies that ada...

journal_title：Medical hypotheses

authors： Usharauli D

更新日期：2010-08-01 00:00:00