Abstract：
:Physiological levels of estrogen would seem to have a possible protective effect on hearing function and estrogen replacement therapy may delay hearing loss in menopausal women. Treatment of healthy menopausal women with Tibolone for 6 months resulted in improvement in audiometry results at low frequencies which was more prominent on the right side. The reason of better improvement on the right side is not known. There might be some other factors modifying the condition or effect of the drug such as laterality. There might be hearing lateralization in menopausal women. Especially significant improvement on right ear might be explained by differences in distribution of estrogen receptor (ER) in the ear, in another words lateralization of ER concentration. ER-α and -β might be more dense in the right ear, so give better response to estrogen treatment. Another reason might be difference in bone mineral density of sides of body which is lower on the right side. Similarly lower bone mineral density right ear bones would cause better response to estrogen therapy and better improvement in audiometry results on that side.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Köşüş N,Köşüş A,Turhan NÖdoi
10.1016/j.mehy.2010.11.018subject
Has Abstractpub_date
2011-03-01 00:00:00pages
447-9issue
3eissn
0306-9877issn
1532-2777pii
S0306-9877(10)00481-0journal_volume
76pub_type
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