Discrepancy in improvement of hearing loss between left and right ears after postmenopausal hormone therapy.


:Physiological levels of estrogen would seem to have a possible protective effect on hearing function and estrogen replacement therapy may delay hearing loss in menopausal women. Treatment of healthy menopausal women with Tibolone for 6 months resulted in improvement in audiometry results at low frequencies which was more prominent on the right side. The reason of better improvement on the right side is not known. There might be some other factors modifying the condition or effect of the drug such as laterality. There might be hearing lateralization in menopausal women. Especially significant improvement on right ear might be explained by differences in distribution of estrogen receptor (ER) in the ear, in another words lateralization of ER concentration. ER-α and -β might be more dense in the right ear, so give better response to estrogen treatment. Another reason might be difference in bone mineral density of sides of body which is lower on the right side. Similarly lower bone mineral density right ear bones would cause better response to estrogen therapy and better improvement in audiometry results on that side.


Med Hypotheses


Medical hypotheses


Köşüş N,Köşüş A,Turhan NÖ




Has Abstract


2011-03-01 00:00:00














  • DCoH: A novel biomarker for diagnosing acute kidney injury.

    abstract::Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Singh V

    更新日期:2016-10-01 00:00:00

  • T and B lymphocytes: two different cell populations for the "first defence barrier" at cutaneous and mucosal levels?

    abstract::Data on lymphocyte biology indicate that the humoral system of B-cells is specifically active with precise analogies at all mucosal levels. Might there be a corresponding function for T-lymphocytes at the cutaneous structure level? Certain physiological findings appear to suggest that the two main lymphocyte populatio...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Franchi F,Seminara P,Montella F

    更新日期:1981-09-01 00:00:00

  • FNDC5/irisin, a molecular target for boosting reward-related learning and motivation.

    abstract::Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and ha...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Zsuga J,Tajti G,Papp C,Juhasz B,Gesztelyi R

    更新日期:2016-05-01 00:00:00

  • The aetiology of premenstrual syndrome is with the progesterone receptors.

    abstract::Recent work by molecular biologists into the behaviour of progesterone receptors (PR) has suggested an aetiological hypothesis for premenstrual syndrome (PMS). The proposition is that PMS is related to the transport by PR of sufficient progesterone (P) molecules into the cell nuclei during menstruating years. PR are w...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Dalton K

    更新日期:1990-04-01 00:00:00

  • Bilateral middle cerebral artery thromboembolic occlusion. Could maternal hyperthermia be a detrimental factor?

    abstract::We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

    更新日期:2011-08-01 00:00:00

  • AIDS possibly caused by HIV and latent malaria coinfection.

    abstract::The presented hypothesis suggests that chronic latent malaria infection prepares the niche where the otherwise feeble HIV coinfection can thrive and cause AIDS. It is suggested that the roots of the HIV outbreak and AIDS pandemic lay in the urbanization processes in Africa that resulted in the eradication of the Anoph...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Yaffe I

    更新日期:2001-10-01 00:00:00

  • Predictive role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in normal-tension glaucoma.

    abstract::As a type of primary open-angle glaucoma, normal-tension glaucoma (NTG) is a health problem that manifests itself with low intraocular pressure (IOP) levels and preserves its importance for public health care. In population-based screenings, which take the IOP levels of 21mmHg as a cut-off for the diagnosis of glaucom...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Atalay K,Kaldirim Erdogan H,Kirgiz A,Asik Nacaroglu S

    更新日期:2017-06-01 00:00:00

  • Ictogenesis: the origin of seizures in humans. A new look at an old theory.

    abstract::Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues to elude medical science. Antiepileptic drug (AED) therapy fails to control seizures in 20% of patients with primary generalized epilepsy and 35% of patients with partial epil...

    journal_title:Medical hypotheses

    pub_type: 历史文章,杂志文章


    authors: Doman G,Pelligra R

    更新日期:2003-01-01 00:00:00

  • A book of ideas collected from Medical Hypotheses: Death can be cured by Roger Dobson.

    abstract::A new collection of ideas from Medical Hypotheses by Roger Dobson is entitled Death can be cured and 99 other Medical Hypotheses. It consists of humorous summaries of Medical Hypotheses articles from the past 30 years. The book's humour derives mainly from the subject matter, although sometimes also from the 'unconven...

    journal_title:Medical hypotheses

    pub_type: 社论


    authors: Charlton BG

    更新日期:2008-01-01 00:00:00

  • Hypothesis: Role for the circadian Clock system and sleep in the pathogenesis of adhesions and chronic pelvic pain?

    abstract::Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

    更新日期:2011-03-01 00:00:00

  • Oral mucosal pellicle as an immune protection against micro-organisms in patients with recurrent aphthous stomatitis: A hypothesis.

    abstract::Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative diseases of oral mucosa affecting an estimate of 20% of the world's population. Majority of the people affected by RAS are under 30 years of age. RAS is located on the lining (non-keratinized) oral mucosa, i.e. buccal mucosa, lateral side of the tongue,...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Pärssinen M,Jäsberg H,Mikkonen JJW,Kullaa AM

    更新日期:2021-01-01 00:00:00

  • Treatment-induced stress syndromes.

    abstract::Placebo controlled trials in disease states as currently constituted are designed to show a drug "works" when in fact it may not. Efficacy of this type may be constructed in trials that demonstrate some marginal superiority of a drug over placebo in disease states that do not take into account any potentialities of th...

    journal_title:Medical hypotheses

    pub_type: 社论,历史文章,评审


    authors: Healy D

    更新日期:2010-05-01 00:00:00

  • Etiology of antisocial personality disorder: benefits for society from an evolutionary standpoint.

    abstract::As human society is mainly cooperative, it is not clear how antisocial personality disorder (APD) persists. The current explanation is that sociopaths are cheaters who maximize their fitness by taking advantages from others. Although this argument is valid, we show here that society also benefits from APD. We propose ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Miric D,Hallet-Mathieu AM,Amar G

    更新日期:2005-01-01 00:00:00

  • Reducing the risk of skin pathologies in diabetics by using copper impregnated socks.

    abstract::Diabetic individuals frequently suffer from skin pathologies, especially in their feet. Co-existing peripheral vascular disease and neuropathy exacerbate the capacity of these individuals to cope with infections, minor cuts and wounds, often leading to hard to treat and chronic ulcers. Copper has potent anti-fungal an...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Borkow G,Zatcoff RC,Gabbay J

    更新日期:2009-12-01 00:00:00

  • Stress-induced suppression of the cellular immune reactions: on the neuroendocrine control of the immune system.

    abstract::Immune competence is considered as a state of equilibrium between humoral and cellular immunity. This notion fits well with the functionally antagonistic cytokine profiles in cell groups of CD4(+)-helper cells as described by Mosmann and Coffman. The Th-1 cells release mainly IL-2, IL-12 and IFN gamma and thereby stim...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hässig A,Wen-Xi L,Stampfli K

    更新日期:1996-06-01 00:00:00

  • Depression and the causal role of specific memory system degenerations: link may be supported by reported therapeutic benefits of Omega 3 fatty acids.

    abstract::It is well documented that depressed patients, as a result of their illness, often experience some difficulties with their memory. This hypothesis suggests a vice-versa; that it is a gradual impairment and ultimate failure of specific memory systems that may underpin the onset and continuation of a depressive illness....

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Frais AT

    更新日期:2007-01-01 00:00:00

  • Vitamin D regulates the production of vascular endothelial growth factor: A triggering cause in the pathogenesis of rheumatic heart disease?

    abstract::Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Sarkar S,Chopra S,Rohit MK,Banerjee D,Chakraborti A

    更新日期:2016-10-01 00:00:00

  • Speculations on vitamin K, VKORC1 genotype and autism.

    abstract::Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberration...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: DeSoto MC

    更新日期:2016-11-01 00:00:00

  • The potential importance of steroids in the treatment of autistic spectrum disorders and other disorders involving mercury toxicity.

    abstract::Autism is a neurodevelopmental disorder that according to the Centers for Disease Control and Prevention (CDC) affects 1 in 150 children in the United States. Autism is characterized by impairments in social relatedness and communication, repetitive behaviors, abnormal movements, and sensory dysfunction. Recently emer...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Geier MR,Geier DA

    更新日期:2005-01-01 00:00:00

  • Pathophysiology of postoperative delirium: systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment.

    abstract::Postoperative delirium represents a serious complication after major surgery. Patients suffer from anxiety, hallucinations and delusions, and have higher postoperative morbidity and mortality. Generally, the role of acetylcholine deficiency in delirium pathophysiology is widely accepted. How this pathologic state evol...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Hála M

    更新日期:2007-01-01 00:00:00

  • Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors.

    abstract::A mechanism of action for Panax ginseng (PG) and Eleutherococcus senticosus (ES) is proposed which explains how they could produce the paradoxical effect of sometimes increasing and sometimes decreasing the stress response. The mechanism suggests that this biphasic effect results from increased occupancy of positive a...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Gaffney BT,Hügel HM,Rich PA

    更新日期:2001-05-01 00:00:00

  • Three-dimensional spring model: a new hypothesis of pathogenesis of adolescent idiopathic scoliosis.

    abstract::The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Yang Z,Xie Y,Li M

    更新日期:2009-11-01 00:00:00

  • A circadian model for viral persistence.

    abstract::Persistently infecting DNA viruses depend heavily on host cell DNA synthesis machinery. Replication of cellular and viral DNA is inhibited by mutagenic stress. It is hypothesized that diurnal regulation of viral DNA replication may occur at the level of cell cycle checkpoints and DNA repair, to protect DNA from exposu...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Shadan FF

    更新日期:2007-01-01 00:00:00

  • Tumor-derived microvesicles: the metastasomes.

    abstract::Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Ghasemi R,Grassadonia A,Tinari N,Piccolo E,Natoli C,Tomao F,Iacobelli S

    更新日期:2013-01-01 00:00:00

  • Immune reaction links disease progression in cancer patients with depression.

    abstract::Mood disturbances and depression are supposed to have a negative impact on patients' outcome in malignant tumour disease. On the other hand, poor prognosis in cancer patients is associated with chronic immune challenge which is paralleled by enhanced degradation of the essential amino acid tryptophan and thus decrease...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Murr C,Widner B,Sperner-Unterweger B,Ledochowski M,Schubert C,Fuchs D

    更新日期:2000-08-01 00:00:00

  • Down-shifting among top UK scientists? - the decline of 'revolutionary science' and the rise of 'normal science' in the UK compared with the USA.

    abstract::It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...

    journal_title:Medical hypotheses

    pub_type: 社论


    authors: Charlton BG,Andras P

    更新日期:2008-01-01 00:00:00

  • gamma-Glutamyltransferase is a promising biomarker for cardiovascular risk.

    abstract::Oxidative stress plays a crucial role in a variety of clinical settings of atherogenesis, and mediates many pathways linked to atherosclerosis and inflammation. gamma-Glutamyltransferase (GGT), an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis an...

    journal_title:Medical hypotheses

    pub_type: 杂志文章,评审


    authors: Turgut O,Yilmaz A,Yalta K,Karadas F,Birhan Yilmaz M

    更新日期:2006-01-01 00:00:00

  • Commitment reversion model of unrestricted cell growth.

    abstract::Through the analysis of accumulated experimental data of cell growth, a model of unrestricted cell growth is presented here. This model is based hypothetically on the cellular commitment to senescence as in the previously presented commitment theory. Cells are divided into 3 types, namely uncommitted cells, committed ...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Tsuboi K,Hatabu H,Lee K,Nio Y,Tobe T,Hatanaka M

    更新日期:1992-08-01 00:00:00

  • The psychological puzzle presented by physiological acts.

    abstract:UNLABELLED:Physiological acts present the puzzle that we are unable to explain how we performed them, how we solved the technical difficulties involved in their execution. For instance, when we sing, we produce various musical notes by changing the shape of the larynx. The normal person does not even know what the lary...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: Seely S

    更新日期:2002-12-01 00:00:00

  • Gender differences in stem cell population are induced by pregnancy.

    abstract::Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in h...

    journal_title:Medical hypotheses

    pub_type: 杂志文章


    authors: El-Badri NS,Groer M

    更新日期:2012-10-01 00:00:00