Abstract:
:A comparison is made of the x-ray induced thyroid adenocarcinoma in the rat by the in-vitro, in-vivo method of Clifton et al. with previous data of Doniach on in-vivo irradiation in whole animals. The Clifton data consists of only one point at 500 rad. I have assumed that the probability of transformation per viable cell from 0 to 500 rad is proportioned to dose and that at higher doses, it is proportional to dose squared. The fraction of rats developing adenocarcinoma agrees with the data of Doniach at 500 and 1100 rads. The rest of the data is filled in by calculation.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Rosen Pdoi
10.1016/0306-9877(84)90070-7subject
Has Abstractpub_date
1984-04-01 00:00:00pages
381-4issue
4eissn
0306-9877issn
1532-2777pii
0306-9877(84)90070-7journal_volume
13pub_type
杂志文章abstract::Oral water irrigation devices (WIDs) are widely used for oral physiotherapy in homes and dental clinics throughout the world. A major area of concern in the use of WIDs has been the possibility of injury to the sulcular epithelium and underlying tissue. There are several documented clinical cases of tissue injury with...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(85)90110-0
更新日期:1985-12-01 00:00:00
abstract::It was hypothesized decades ago that reduced levels of brain monoamines such as serotonin or norepinephrine form, at least in part, a pathophysiological basis for major depression. Consistent with this hypothesis, a conventional strategy used, with varying success, to treat major depression involves administering anti...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.03.023
更新日期:2013-06-01 00:00:00
abstract::Evidence exists for the presence of a neuro-anatomy that can produce cardiac vasospasm. Recent experimental and clinical data suggest that this neuro-anatomic mechanism can be activated by behavioral events in the psycho-social surround of the patient with coronary artery disease. I hypothesize that this mechanism can...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(87)90214-3
更新日期:1987-12-01 00:00:00
abstract::Inotropic treatment remains the cornerstone for cardiogenic shock, an emergency that requires immediate resuscitative therapy before shock irreversibly damages vital organs. Although the sympathomimetic drug dobutamine is the most widely-used inotropic drug worldwide, it has several side effects including sinus tachyc...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.05.002
更新日期:2013-08-01 00:00:00
abstract::Recently, the concept of drug delivery requires that the release of encapsulated drug be produced only at the diseased site with controllable rates. Given that thermosensitive hydrogels have been widely investigated for controlled delivery based on their phase transition, we speculate that nanoparticles with the novel...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.03.023
更新日期:2008-08-01 00:00:00
abstract::HLA-G is a nonclassical HLA immunotolerogenic molecule expressed in different human cell types. Successful embryo implantation is a consequence of information exchange between the uterus and the blastocyst. It is widely accepted that HLA-G expression by the fetus promotes the establishment of several mechanisms that, ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.03.030
更新日期:2017-05-01 00:00:00
abstract::Trypanosomiasis is common in Africa and South America. The surface of trypanosomes is covered by glycosyl phosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) that contains the fatty acid myristate (14:0) as its lipid moiety that is essential for its survival. Myristic acid, being a saturated fatty a...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.11.002
更新日期:2010-04-01 00:00:00
abstract::Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric b...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2017.08.012
更新日期:2017-09-01 00:00:00
abstract::Delivery of large DNA constructs is necessary for combinatorial, anti-aging gene therapy. However, this is hindered by the lack of a non-inflammatory vector with sufficient packaging space and the ability to effectively spread through tissue. It is possible that a mitochondrion, altered to be able to secrete therapeut...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.05.014
更新日期:2018-08-01 00:00:00
abstract::Ergothioneine is believed not to be synthesized by man but it accumulates to high concentrations in some mammalian cells as a result of dietary intake. Ergothioneine is known to chelate divalent metal ions with high affinity. Other substances which are potent chelators of divalent metal ions such as diphenylthiocarbaz...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(82)90137-2
更新日期:1982-08-01 00:00:00
abstract::Chlorination of potable water supplies high in organics may yield carcinogenic compounds such as trihalomethanes. Chlorine dioxide has been proposed as an alternative disinfectant to chlorine. However, chlorine dioxide is a strong oxidant that forms significant amounts of chlorite when added to potable water supplies,...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(78)90017-8
更新日期:1978-09-01 00:00:00
abstract::The concept of reentry as the most important element in a hypothesis for consciousness proposed by Edelman and Tononi is reviewed. Reentry, is a process of ongoing parallel and recursive signalling between separate neuronal groups along parallel reciprocally fibers that link these groups anatomically. Reentry alters t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.007
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109869
更新日期:2020-10-01 00:00:00
abstract::The various neurotransmitter systems postulated to be involved in the pathogenesis of Gilles de la Tourette syndrome(GTS) are described with special reference to the endogenous opioid system(EOS). Malfunction of the opioid system is proposed as the underlying disturbance in this disease causing secondary dysfunction o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90112-x
更新日期:1986-04-01 00:00:00
abstract::Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development o...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2013.10.030
更新日期:2014-01-01 00:00:00
abstract::Stroke is a major cause of neurological disability across all countries in the world. Functional recovery after stroke is limited because of neuronal death and degeneration. Although early reperfusion therapy may improve outcome, thrombolysis does not reverse ischaemic neuronal death and carries the risk of cerebral h...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.01.091
更新日期:2007-01-01 00:00:00
abstract::Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in h...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.06.029
更新日期:2012-10-01 00:00:00
abstract::It is sometimes asserted that UK science is thriving, at other times that it has declined. We suggest that both assertions are partly true because the UK is thriving with respect to the volume of 'normal' science production but at the same time declining in the highest level of 'revolutionary' science. Revolutionary s...
journal_title:Medical hypotheses
pub_type: 社论
doi:10.1016/j.mehy.2007.12.004
更新日期:2008-01-01 00:00:00
abstract::The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.02.046
更新日期:2009-11-01 00:00:00
abstract::The mechanism of dermatomyositis/polymyositis (DM/PM) is unknown. There are multiple probable trigger mechanisms. Internal malignancy is a specific trigger for some cases of DM/PM. It is known that there are marked changes in the extracellular matrix around tumors and that various fractions of depolymerized glycosamin...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90033-m
更新日期:1993-07-01 00:00:00
abstract::The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90192-9
更新日期:1996-04-01 00:00:00
abstract::Bipedal locomotion and fine motility of hand and larynx of humans introduced musculoskeletal adaptations, new pyramidal, corticostriatal, corticobulbar, nigrostriatal, and cerebellar pathways and expansions of prefrontal, cingular, parieto-temporal and occipital cortices with derived new brain capabilities. All select...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.05.034
更新日期:2008-11-01 00:00:00
abstract::Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109938
更新日期:2020-11-01 00:00:00
abstract::Thrombotic thrombocytopenic purpura (TTP) is a severe, occlusive, thrombotic microangiopathy characterized by a systemic platelet aggregation, organ ischemia, profound thrombocytopenia and erythrocyte fragmentation. Recent observations have documented that a deficiency of a von Willebrand factor (VWF)-cleaving proteas...
journal_title:Medical hypotheses
pub_type: 临床试验,杂志文章
doi:10.1016/j.mehy.2005.06.015
更新日期:2005-01-01 00:00:00
abstract::Exercise-induced hypoalgesia is characterised by a reduction in pain sensitivity following exercise. Recently, low intensity exercise performed with blood flow restriction has been shown to induce hypoalgesia. The purpose of this manuscript is to discuss the mechanisms of exercise-induced hypoalgesia and provide ratio...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2019.109370
更新日期:2019-11-01 00:00:00
abstract::For American medical historiography, to borrow from Dickens, these are the best of times and the worst of times. These are the times when rigorous scholarship has been brought to bear on the field (with great improvement in the quality of research) and when medicine is disappearing from its own history. These are the ...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/0306-9877(92)90079-r
更新日期:1992-06-01 00:00:00
abstract::For many years there was a general belief that the enzyme renin, having been secreted into the circulation by the kidney in response to appropriate stimuli, initially generates the inactive decapeptide angiotensin I in the bloodstream. This is then converted to the biologically active octapeptide angiotensin II by ang...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1201
更新日期:2001-04-01 00:00:00
abstract::I hypothesize that the intermediates of the kynurenine (Kyn) pathway (KP) of tryptophan (Trp) degradation kynurenic acid (KA) and quinolinic acid (QA) play opposite roles in inflammatory diseases, with KA being antiinflammatory and QA being immunosuppressant. Darlington et al. have demonstrated a decrease in the ratio...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2018.06.021
更新日期:2018-09-01 00:00:00
abstract::The DSM is not brain-related and is thus unable to relate clinical assessments to putative brain disturbances. 'Clinical brain profiling' (CBP) involves the rearrangement of clinical findings to assess the relevant disturbances in brain dynamics. CBP has three major pathological dimensions, (1) disorders of basic brai...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.02.039
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Somatization is a multisomatoform disorder characterized by medically unexplained, functional or psychosomatic symptoms. Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS:This paper reviews the evidence that such symptoms are o...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.02.023
更新日期:2012-06-01 00:00:00