Abstract:
:Invasive carcinoma originates from the epithelial cells lining the lumen of an organ. It is often preceded by metaplasia, dysplasia or carcinoma in situ. The purpose of this review is to suggest that this disease of the epithelium may be, in part, the result of underlying tissue-based disorganization. Human cancer is frequently associated with pre-existing tissue disease. For example, hepatocellular carcinoma usually occurs in patients with a macronodular cirrhotic liver. Most lung cancers arise among patients with chronic lung disease (bronchitis, emphysema, and chronic infection). Mechanical forces appear to play a major role in regulating normal and cancer cell growth. The loss of cell polarity by neoplastic cells, coupled to an otherwise normal growth rate is enough to explain the cancer star-shaped pattern. By changing the plane of cell division, tumor cells may escape physical constraints from surrounding cells and divide. Loss of cell polarity and the resulting cell proliferation appears to be a consequence of either tissue-based disorganization (chronic inflammation, fibrosis) or of direct carcinogenic insult. The multiple mutations frequently described in cancer may be, in part, secondary to physical stress and not primary events. Several animal and clinical trials have shown that tissue disruption (i.e. radiation-induced fibrosis or liver cirrhosis) can be successfully treated. It is possible that treatment targeted at tissue disruption would delay or reduce cancer incidence regardless of the precise biological mechanism of carcinogenesis.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Schwartz L,Balosso J,Baillet F,Brun B,Amman JP,Sasco AJdoi
10.1054/mehy.2001.1539keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
340-6issue
4eissn
0306-9877issn
1532-2777pii
S0306987701915397journal_volume
58pub_type
杂志文章abstract::The terminology relating to 'psychological stress' is so confused and ambiguous that research in this field - and application of its results - must surely be hampered. Relevant words with conflicting usages and scientific definitions include 'stress' itself, 'stressor', 'strain', 'challenge', 'demand', 'threat', 'reso...
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更新日期:2002-05-01 00:00:00
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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doi:10.1016/j.mehy.2009.10.009
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
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