Pathophysiology of postoperative delirium: systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment.

abstract：:The incidence and prevalence of Crohn's disease (CD) among children in developed countries is extremely high. Although, dietary factors have long been implicated, to date no single causative element has been identified. Risks or benefits for CD from dietary elements would depend on their appropriate metabolism within ...

journal_title：Medical hypotheses

authors： K Amre D,G Seidman E

更新日期：2003-03-01 00:00:00

abstract：:Why is modern science less efficient than it used to be, why has revolutionary science declined, and why has science become so dishonest? One plausible explanation behind these observations comes from an essay First and second things published by CS Lewis. First Things are the goals that are given priority as the prim...

journal_title：Medical hypotheses

authors： Charlton BG

更新日期：2010-01-01 00:00:00

abstract：:Tourette syndrome is a chronic, idiopathic, childhood onset neuropsychiatric disorder with both motor and vocal tics. Tourette syndrome occurs worldwide and the clinical features are similar irrespective of the country of origin, with genetic causes suspected, but to date not proven. A link between red hair colour and...

journal_title：Medical hypotheses

authors： Sterling-Levis K,Williams K

更新日期：2009-11-01 00:00:00

abstract：:Non-invasive molecular analysis of fetal DNA is the diagnostic goal of prenatal medicine. Circulating fetal DNA can be detected in maternal plasma. Recently, it has been detected in the urine of pregnant women. We hypothesize that fetal DNA is present also in maternal saliva and that advances in stabilization and isol...

journal_title：Medical hypotheses

authors： Vlková B,Szemes T,Minárik G,Turna J,Celec P

更新日期：2010-02-01 00:00:00

abstract：:At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Give...

journal_title：Medical hypotheses

authors： Tao H,Ge G,Li W,Liang X,Wang H,Li N,Sun H,Zhang W,Geng D

更新日期：2020-12-01 00:00:00

abstract：:The present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification p...

journal_title：Medical hypotheses

authors： Açıkoğlu M,Tuncer SA

更新日期：2020-02-01 00:00:00

abstract：:Neural tube defect (NTD) is more common among spontaneously aborted fetuses than in infants born in the third trimester, but there is no direct evidence that NTD-affected conceptuses, presenting at these two different gestational ages, are components of a single disease process. Evidence for homology is here presented...

journal_title：Medical hypotheses

authors： Machin GA

更新日期：1979-02-01 00:00:00

abstract：:This paper compares two models of the sense of smell and demonstrates that the new model has advantages over the accepted model with implications for medical research. The accepted transduction model had an odourant or pheromone contacting an aqueous sensory lymph then movement through it to a receptor membrane beneat...

journal_title：Medical hypotheses

authors： Nicholson B

更新日期：2001-09-01 00:00:00

abstract：:Many clinical trials have clearly demonstrated the benefit of statins in the prevention of coronary heart disease. Although other effects have subsequently been described, the so-called pleiotropic effects of statins, there is a tendency to relate all those effects, more or less directly, to inhibition of 3-hydroxy-3-...

journal_title：Medical hypotheses

authors： Negrão MR,Mota A,Azevedo I,Martins MJ

更新日期：2006-01-01 00:00:00

abstract：:Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (espec...

journal_title：Medical hypotheses

authors： Kowara M,Kasarełło K,Czarzasta K,Opolski G,Cudnoch-Jędrzejewska A

更新日期：2019-01-01 00:00:00

abstract：:Learning disability, attentional disorder and childhood major depression are frequent diagnoses in children with behavioral disturbances and impaired school performance. All three disorders are associated with right cerebral hemisphere dysfunction. Anatomical disturbance of right hemisphere function results in learnin...

journal_title：Medical hypotheses

authors： Brumback RA,Staton RD

更新日期：1982-05-01 00:00:00

abstract：:We have previously presented a new Systemic Evolutionary Theory of Cancer (SETOC) based on the failure of proper endosymbiosis in eukaryotic cells. Here, we propose that the progressive uncoupling of two endosymbiotic subsystems (information and energy) inside the cell, as a consequence of long-term injuries, gives ri...

journal_title：Medical hypotheses

authors： Mazzocca A,Ferraro G,Misciagna G,Fais S

更新日期：2018-12-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is a severe pulmonary sequela which can affect up to 15% of patients with cirrhotic liver disease. There is no treatment for HPS other than liver transplantation. The cause of HPS is incompletely understood, but the pulmonary vasodilation in HPS is thought to be related to increased leve...

journal_title：Medical hypotheses

authors： Altschuler EL,Kast RE

更新日期：2004-01-01 00:00:00

abstract：:At present, researchers are still debating the effect of blue light on the eyes.Studies have shown thatwhile blue lighthelpsto maintain normal biological rhythms,excessive blue light radiation mayinduce fundus lesions. The preliminary survey shows that the incidence of vitreous floaters is high among digital device us...

journal_title：Medical hypotheses

authors： Chen JT,Wu HJ

更新日期：2020-06-01 00:00:00

abstract：:The S-oxidation of S-carboxymethyl-l-cysteine has been reported previously to be a biomarker of disease susceptibility in Parkinson's disease and Amyotrophic lateral sclerosis. In this investigation, the original observations have been confirmed with the incidence of the poor metaboliser phenotype (no urinary recovery...

journal_title：Medical hypotheses

authors： Steventon GB,Mitchell SC

更新日期：2018-09-01 00:00:00

abstract：:"Consciousness" "mood," "identity" and "personality" are all emergent properties from whole-brain organizations; these are typically disturbed in psychiatric disorders. This work proposes that the underlying etiopathology of mental disorders originates from disturbances to global brain dynamics, or "Globalopathies" th...

journal_title：Medical hypotheses

authors： Peled A

更新日期：2013-12-01 00:00:00

abstract：:Logic, a fundamental component of research in the exact sciences is often not applied in prominent fields of medical research. Investigation into the aetiopathogenesis of headache, vertigo, and fatigue--acknowledged as the commonest and amongst the most prominent and debilitating of symptoms known to mankind--may be s...

journal_title：Medical hypotheses

authors： Eidelman D

更新日期：1990-04-01 00:00:00

abstract：:Neuronal degeneration in the post-menopausal term leads to cognitive symptoms such as anxiety, difficulty in concentrating, overreacting to minor upsets, quickly becoming irritated and forgetfulness in approximately 70-80% of all women around the world. These symptoms, which result from microtubule damage in the axon ...

journal_title：Medical hypotheses

authors： Karamese M,Aksak S,Gundogdu OB,Unal B

更新日期：2013-09-01 00:00:00

abstract：:Clinical studies have shown that ionic zinc (Zn2+) dissolved in the mouth shortened manifestations of the common cold significantly, by an unknown mechanism. The observed immediate effect on symptoms is consonant with osmotic transport of Zn2+, placing a temporary chemical clamp on critical nerves. It is proposed that...

journal_title：Medical hypotheses

authors： Novick SG,Godfrey JC,Godfrey NJ,Wilder HR

更新日期：1996-03-01 00:00:00

abstract：:Initial diagnosis of acute kidney injury (AKI) is usually based on measuring serum-creatinine and blood urea nitrogen levels; however such measurements are still poor in identifying renal injuries at initial stages. These standard matrices are not enough to monitor the outcome and progression of AKI. The prognosis pre...

journal_title：Medical hypotheses

authors： Singh V

更新日期：2016-10-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a common and underdiagnosed medical disorder. OSA is associated with the symptoms of excessive daytime sleepiness (EDS). These patients typically follow a sedentary lifestyle, and sedentary behavior is related to impaired fluid dynamics in the lower body, particularly the legs. In a su...

journal_title：Medical hypotheses

authors： Mirrakhimov AE

更新日期：2013-02-01 00:00:00

abstract：:Inflammatory eye diseases such as uveitis are common and may eventually result in vision loss. Iron can play a critical role in ocular inflammation via promoting the generation of oxygen free radicals and it is also nutritionally essential for microbial growth. Considering this involvement of iron in inflammation and ...

journal_title：Medical hypotheses

authors： Chen J,Zhou J,Kelly M,Holbein BE,Lehmann C

更新日期：2017-06-01 00:00:00

abstract：:This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadv...

journal_title：Medical hypotheses

authors： Siefkes D

更新日期：1993-10-01 00:00:00

abstract：:Knowledge about how information is stored in neurons of animals and in the human brain is still incomplete. A hypothesis related to long-term changes in synaptic efficiency has strong experimental support, but does not seem to be able to explain all observations. It has recently been proposed that magnetite together w...

journal_title：Medical hypotheses

authors： Alfsen EM,Størmer FC,Njå A,Walløe L

更新日期：2018-10-01 00:00:00

abstract：:Metformin, a drug widely used in the treatment of type II diabetes mellitus (T2DM), has been the focus of interest as a potential therapeutic agent for certain types of malignancies, including gynaecological cancers [i.e. endometrial cancer (EC)]. Although the exact mechanism behind the potential anticancer activity o...

journal_title：Medical hypotheses

authors： Karadeniz Z,Aynacıoğlu AŞ,Bilir A,Tuna MY

更新日期：2020-01-01 00:00:00

abstract：:Developmental alcohol exposure adversely influences the developing brain. Alcohol exposure during rapid brain growth causes cell loss, alters connections between brain regions, and lowers the production of biological substances responsible for the communication among neurons. It is reasonable to suggest that alcohol m...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...

journal_title：Medical hypotheses

authors： Anselmi A,Ruggieri VG,Harmouche M,Mascle S,Auffret V,Le Breton H,Beneux X,Verhoye JP

更新日期：2015-05-01 00:00:00

abstract：:Neutrophils are activated in the coronary circulation during acute coronary events (unstable angina and myocardial infarction), often prior to the onset of ischemic damage. Moreover, neutrophils infiltrate coronary plaque in these circumstances, and may contribute to the rupture or erosion of this plaque, triggering t...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2004-01-01 00:00:00

abstract：:Narcolepsy type 1 is a lifelong sleep disorder characterized by the loss of hypocretin-producing neurons in the brain. Environmental agents, including influenza, neurotoxic metals, and combustion smoke, have been implicated in the pathogenesis, especially in carriers of the human leukocyte antigen class II DQB1*06:02 ...

journal_title：Medical hypotheses

authors： Mori I

更新日期：2019-10-01 00:00:00

abstract：:The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

journal_title：Medical hypotheses

authors： Altschuler E

更新日期：1999-07-01 00:00:00