Abstract:
:This article reviews the significance of changes in the level of cerebrospinal fluid acetylcholinesterase or cholinesterase in patients with Alzheimer's disease or other dementias. Evidence has shown that the methodology of assaying cerebrospinal fluid acetylcholinesterase or cholinesterase is reliable and the activity of the enzyme is stable. Low acetylcholinesterase or cholinesterase levels presenting in cerebrospinal fluid of a demented individual may confirm the clinical diagnosis of Alzheimer's disease or other organic dementia. A low activity of acetylcholinesterase or cholinesterase existing in cerebrospinal fluid of a non-demented individual may indicate a brain at risk, or that the person is in the preclinical stage of dementia. Recognition of the presence of the preclinical stage may be very beneficial for explaining the real meaning of the 'overlap' in the biochemistry and pathology between dementia and non-dementia, and also very important for prevention and treatment. Therefore, the strategy of prevention and of treatment should no longer be designed to inhibit acetylcholinesterase activity. In contrast, it should be designed to enhance the neuronal acetylcholinesterase activity or to delay the degeneration of brain acetylcholinesterase system.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Shen ZXdoi
10.1016/s0306-9877(96)90216-9subject
Has Abstractpub_date
1996-11-01 00:00:00pages
363-76issue
5eissn
0306-9877issn
1532-2777pii
S0306-9877(96)90216-9journal_volume
47pub_type
杂志文章abstract::Numerous studies implicate cellular immunological effector systems in the partial containment of virus replication during the early stages of HIV infection. Immunostimulatory therapeutic regimes designed to enhance virus clearance are therefore theoretically attractive, but are accompanied by the risk of concomitant a...
journal_title:Medical hypotheses
pub_type: 杂志文章
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journal_title:Medical hypotheses
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Medical hypotheses
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pub_type: 杂志文章
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 信件
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更新日期:2020-10-01 00:00:00
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pub_type: 社论,历史文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(94)90002-7
更新日期:1994-05-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90026-b
更新日期:1990-04-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109762
更新日期:2020-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2008.07.058
更新日期:2009-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(95)90056-x
更新日期:1995-08-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90148-x
更新日期:1988-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(96)90071-7
更新日期:1996-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2010.08.029
更新日期:2011-01-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(93)90080-a
更新日期:1993-10-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2012.11.022
更新日期:2013-02-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 信件
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更新日期:2020-11-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Medical hypotheses
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00