Abstract:
:Cytokines and their effects are widely studied in immunology, but the cellular mechanisms responsible for producing these substances are not yet described or proven. Antigen presenting cells (APCs), macrophages and dendritic cells are suitable subjects for such a study. One of the many papers illustrating the interplay between phagocytosis, cytokine secretion, and cell adhesion is one by Kitajima et al. The intracellular processes involve both cytokine secretion and mobilization of the membrane system of the cell. Five pieces of evidence are presented to propose that the Golgi complex is the source both of the membrane translocated and cytokine production. Morphologic evidence is cited that reverse pinicytosis does not play a significant role in the mouse macrophage system.
journal_name
Med Hypothesesjournal_title
Medical hypothesesauthors
Fedorko MEdoi
10.1054/mehy.1997.0720keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
107-9issue
2eissn
0306-9877issn
1532-2777pii
S0306-9877(97)90720-9journal_volume
53pub_type
杂志文章abstract::A wealth of research data points to increased oxidative stress as a key driver of the cardiac remodeling triggered by chronic pressure overload, loss of functional myocardial tissue, or atrial fibrillation. Oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the def...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2009.12.025
更新日期:2010-08-01 00:00:00
abstract::It is postulated that the induction of immunological tolerance to chemical carcinogens is due to the penetration of carcinogens and its albumin and DNA adducts from the maternal organism into the embryo. Maternal serum lgG-antibodies to carcinogens promote the transportation of carcinogens and adducts into the embryo ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1054/mehy.2000.1393
更新日期:2001-07-01 00:00:00
abstract::Since forced unilateral nostril breathing activates the contralateral brain hemisphere, an animal analogue of this technique could be provided by methylmethacrylate gluing large plastic pellets in either the right or left nostrils in a group of rats. A large number of physiological, pharmacological, and immunological ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90047-9
更新日期:1989-03-01 00:00:00
abstract::Electron spin resonance (ESR) spin trapping methodology has been used to study the reactions of manganese dusts with glutathione, employing alpha-(4-pyridyl-1-oxide)-N-tert-butyl-nitrone (PBN) and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as spin traps. The results show evidence for the glutathionyl radical formation in...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90184-g
更新日期:1990-10-01 00:00:00
abstract::The morphological changes used to confirm a diagnosis of coeliac disease (CD) are precisely those predicted if the surface energy of the interface between duodenal epithelium and the luminal contents were raised to levels comparable to those demonstrated by the hydrophobic nature of the stomach wall. This hypothesis p...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(90)90126-y
更新日期:1990-07-01 00:00:00
abstract::September 17th, 2009 marks the 15th anniversary of Sir Karl Popper's death. Popper was an outspoken champion of critical rationalism, and a constant critic of authoritarian tendencies in science and society. He was also one of the spiritual founders of this journal and served on its first editorial advisory board. Pop...
journal_title:Medical hypotheses
pub_type: 传,社论,历史文章
doi:10.1016/j.mehy.2009.09.021
更新日期:2009-12-01 00:00:00
abstract::Nitrosamines have been identified in vaginal secretions of women with trichomoniasis. Both nitrites and amines the elements for nitrosamine synthesis are produced by the abnormal-predominantly anaerobic-vaginal flora of patients with bacterial vaginosis/trichomoniasis. The final formation of nitrosamines could also de...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(84)90159-2
更新日期:1984-12-01 00:00:00
abstract::Most cancer cells would not result in devastating tumours if it were not for their ability to metastasize. The process of cancer metastasis involves significant cell shape, motility, and adhesive changes of pre-cancerous cells, and the remodelling of the extracellular matrix, as well as cognate properties of neighbour...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2007.04.042
更新日期:2008-01-01 00:00:00
abstract::Hypertension has become a large burden of global development, but the mechanisms of it have still not been well elucidated. Increased contractility of vascular smooth cells induced by the overactivity of neurohormonal system or stress is one of the main and popular explanations until now. Smoothelin-B, recognized as t...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.038
更新日期:2009-07-01 00:00:00
abstract::Fulminant hepatitis is associated with an 80% mortality rate. Surviving patients do not develop chronic liver disease. Failure to produce adequate amounts of interferon and to achieve an antiviral state seem to be the basic defects in this condition. Tumor necrosis factor (TNF) has been shown to be induced by viruses....
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(88)90140-5
更新日期:1988-11-01 00:00:00
abstract::Endometriosis is a common gynecological disorder that affects approximately 6-10% of the female population impairing the quality of life of patients. Several pathophysiologic pathways have been proposed as potential regulators of its severity; however, to date, the processes that trigger the onset and that influence t...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2019.109414
更新日期:2019-12-01 00:00:00
abstract::Many studies have focused on the detrimental effects of malnourishment to the performance of the brain and peripheral nerves. Undernourished children and adults have been studied extensively to establish these consequences. Little attention has been given to the body habitus that affects optimum neurological performan...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2014.08.012
更新日期:2014-11-01 00:00:00
abstract::Periodontitis significantly decreases survival in hemodialysed patients with end stage renal disease (ESRD). Periodontitis-related microorganisms spreading into the bloodstream are thought to impair blood rheological parameters - for example, increasing whole blood viscosity, aggregating blood elements, and decreasing...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.04.053
更新日期:2010-02-01 00:00:00
abstract::In this work we propose a simple mathematical model for the analysis of the impact of control measures against an emerging infection, namely, the severe acute respiratory syndrome (SARS). The model provides a testable hypothesis by considering a dynamical equation for the contact parameter, which drops exponentially w...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.09.029
更新日期:2005-01-01 00:00:00
abstract::The cranial nerve rhizophathy, commonly presented with trigeminal neuralgia (TN) or hemifacial spasm (HFS), is a sort of hyperexcitability disorders with higher incidence in senior Asian. In this paper, a novel hypothesis on the pathogenesis is proposed and with which some clinical phenomena are explained. In those wi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.109801
更新日期:2020-09-01 00:00:00
abstract::A role for lipopolysaccharides (endotoxins, LPS) in 7 the pathogenesis of Reye's syndrome (RS) has previously been suggested. Impairment of hepatic LPS clearance can lead to systemic endotoxemia as previous studies by this and other laboratories have suggested for several hepatic disorders including RS. Systemic LPS m...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(92)90115-s
更新日期:1992-11-01 00:00:00
abstract::Alzheimer's disease is a debilitating age-related disorder characterized by distinct pathological hallmarks, such as progressive memory loss and cognitive impairment. During the last few years, several cellular signaling pathways have been associated with the pathogenesis of Alzheimer's disease, such as Notch, mTOR an...
journal_title:Medical hypotheses
pub_type: 杂志文章,评审
doi:10.1016/j.mehy.2015.01.026
更新日期:2015-04-01 00:00:00
abstract:UNLABELLED:T helper (Th) lymphocytes have been classified into distinct subsets, Th1 and Th2 on the basis of the cytokines they produce. According to the cross-regulatory properties of Th1 and Th2 cells, one would assume that to be affected by a Th1 type disease increases susceptibility to a Th1 type disease and inhibi...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2006.03.039
更新日期:2006-01-01 00:00:00
abstract::Hypotheses regarding the factors that predispose individuals to developing AIDS after exposure to HTLV-III/LAV are beginning to emerge. It is suggested here that surgical removal of tonsils in childhood may increase the risk of developing opportunistic infections after infection with this newly discovered retrovirus. ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(86)90076-9
更新日期:1986-03-01 00:00:00
abstract::It has been hypothesized that sulfite oxidase deficient persons may be at increased risk to toxicity from SO2 and dietary sulfites widely used for food preservation. Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion. Human and animal studies have shown ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(81)90110-9
更新日期:1981-02-01 00:00:00
abstract::Interleukin (IL)-17 is a pro-inflammatory cytokine originally described in T lymphocytes. Increased production of IL-17 has been linked to the induction of cytokines, chemokines and adhesion molecules in various cell types, effects that likely contribute to a number of inflammatory diseases including rheumatoid arthri...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.009
更新日期:2004-01-01 00:00:00
abstract::Low carbohydrate high fat (LCHF) diets are emerging in popularity. Several athletics have adopted LCHF diets in an attempt to improve exercise performance and body composition by enhancing fat utilization. However, these diets impair maximal and supramaximal exercise performance due to limited glycogen stores as well ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2020.110369
更新日期:2021-01-01 00:00:00
abstract::Primary headaches include migraine, tension, cluster headaches, paroxysmal hemicrania and miscellaneous headaches unassociated with structural lesions. A putative role of the retino-hypothalamic-pineal (RHP) axis in the pathophysiology of primary headaches is reviewed in terms of (1) retinal dysfunction, (2) hypothala...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2005.12.026
更新日期:2006-01-01 00:00:00
abstract::Behcet's disease (BD) is a chronic, multisystem inflammatory disorder characterized by relapsing oral aphthous and genital ulcers, ocular inflammation, erythemanodosum and folliculitis-like lesions of the skin, arthritis, and central nervous system involvement. Its pathogenesis has not been fully elucidated but the et...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2009.01.046
更新日期:2009-07-01 00:00:00
abstract::It is hypothesized that Alzheimer's disease is a human phylogenetic disease which has a common multifactorial pathogenesis in sporadic and familial cases and in Down syndrome, related to a genomic character function G(x). Increments in G(x) accompanied the increased gene expression that sustained brain growth and diff...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(89)90185-0
更新日期:1989-07-01 00:00:00
abstract::Human papillomavirus (HPV) type 16 is causally associated with a subset of oral cancers, predominantly those cancers arising in the oropharynx (OP). Increased HPV16 E6 and E7 oncogene expressions are responsible for the malignant transmission in these cancers. ErbB-2 is the family member most closely implicated in hum...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2004.03.013
更新日期:2004-01-01 00:00:00
abstract::The incidence and prevalence of Crohn's disease (CD) among children in developed countries is extremely high. Although, dietary factors have long been implicated, to date no single causative element has been identified. Risks or benefits for CD from dietary elements would depend on their appropriate metabolism within ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/s0306-9877(02)00401-2
更新日期:2003-03-01 00:00:00
abstract::The rise of anatomical realism in sculpture with the Classical Greeks puzzles art historians. Recently, it has been discovered that the motor cortex perceives motor actions. I argue that Classical artists discovered a new aesthetic based on using art to stimulate not just, as previously, the visual cortex, but also th...
journal_title:Medical hypotheses
pub_type: 历史文章,杂志文章
doi:10.1016/s0306-9877(98)90257-2
更新日期:1998-07-01 00:00:00
abstract::Observations which show that urine output can vary with changes in the contour of the pulse cure, that it can even increase while the mean blood pressure falls during counterpulsation, that the well known hypertensive effect of a renal artery stenosis can also be produced by an aneurysm of the renal artery, cannot be ...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/0306-9877(78)90004-x
更新日期:1978-05-01 00:00:00
abstract::Muscle spindles are increasingly recognized as playing a pivotal role in the cause of dystonia. This development and own laryngeal observations that support the idea of causally "well-intentioned" stuttering motivated us to present the following hypothesis: stuttering events compensate for a sensory problem that arise...
journal_title:Medical hypotheses
pub_type: 杂志文章
doi:10.1016/j.mehy.2012.03.025
更新日期:2012-07-01 00:00:00