Secretion of cytokines and modulation of function of immunologically competent cells.

Abstract:

:Cytokines and their effects are widely studied in immunology, but the cellular mechanisms responsible for producing these substances are not yet described or proven. Antigen presenting cells (APCs), macrophages and dendritic cells are suitable subjects for such a study. One of the many papers illustrating the interplay between phagocytosis, cytokine secretion, and cell adhesion is one by Kitajima et al. The intracellular processes involve both cytokine secretion and mobilization of the membrane system of the cell. Five pieces of evidence are presented to propose that the Golgi complex is the source both of the membrane translocated and cytokine production. Morphologic evidence is cited that reverse pinicytosis does not play a significant role in the mouse macrophage system.

journal_name

Med Hypotheses

journal_title

Medical hypotheses

authors

Fedorko ME

doi

10.1054/mehy.1997.0720

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

107-9

issue

2

eissn

0306-9877

issn

1532-2777

pii

S0306-9877(97)90720-9

journal_volume

53

pub_type

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