听力与言语-语言病理学

行为科学

医学伦理学

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  • International trends in oesophageal cancer survival by histological subtype between 1995 and 2014.

    abstract:INTRODUCTION:Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC). METHODS:The ICBP SURVMARK-2 project...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321089

    authors: Morgan E,Soerjomataram I,Gavin AT,Rutherford MJ,Gatenby P,Bardot A,Ferlay J,Bucher O,De P,Engholm G,Jackson C,Kozie S,Little A,Møller B,Shack L,Tervonen H,Thursfield V,Vernon S,Walsh PM,Woods RR,Finley C,Merrett

    更新日期:2021-02-01 00:00:00

  • Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial.

    abstract:OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321643

    authors: Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

    更新日期:2021-02-01 00:00:00

  • Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses.

    abstract:OBJECTIVES:To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing T2DM (LSDM)) and pancreatic cancer (PC) risk, to explore the direction of causation through Mendelian randomisation (MR) analysis and to assess the mediation role of body mass index (BMI)....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319990

    authors: Molina-Montes E,Coscia C,Gómez-Rubio P,Fernández A,Boenink R,Rava M,Márquez M,Molero X,Löhr M,Sharp L,Michalski CW,Farré A,Perea J,O'Rorke M,Greenhalf W,Iglesias M,Tardón A,Gress TM,Barberá VM,Crnogorac-Jurcevic T,

    更新日期:2021-02-01 00:00:00

  • Inflammatory bowel disease and risk of small bowel cancer: a binational population-based cohort study from Denmark and Sweden.

    abstract:OBJECTIVE:Crohn's disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD). DESIGN:In a binational, population-based cohort study from Sweden and De...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320945

    authors: Axelrad JE,Olén O,Sachs MC,Erichsen R,Pedersen L,Halfvarson J,Askling J,Ekbom A,Sørensen HT,Ludvigsson JF

    更新日期:2021-02-01 00:00:00

  • Endoscopy and central reading in inflammatory bowel disease clinical trials: achievements, challenges and future developments.

    abstract::Central reading, that is, independent, off-site, blinded review or reading of imaging endpoints, has been identified as a crucial component in the conduct and analysis of inflammatory bowel disease clinical trials. Central reading is the final step in a workflow that has many parts, all of which can be improved. Furth...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2020-320690

    authors: Gottlieb K,Daperno M,Usiskin K,Sands BE,Ahmad H,Howden CW,Karnes W,Oh YS,Modesto I,Marano C,Stidham RW,Reinisch W

    更新日期:2021-02-01 00:00:00

  • Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19.

    abstract:OBJECTIVE:Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in the GI tract during disease course is largely unknown. We investigated temporal transcriptional activity of SARS-CoV-2 and its association wi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322294

    authors: Zuo T,Liu Q,Zhang F,Lui GC,Tso EY,Yeoh YK,Chen Z,Boon SS,Chan FK,Chan PK,Ng SC

    更新日期:2021-02-01 00:00:00

  • Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.

    abstract:OBJECTIVE:Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322571

    authors: Allweiss L,Giersch K,Pirosu A,Volz T,Muench RC,Beran RK,Urban S,Javanbakht H,Fletcher SP,Lütgehetmann M,Dandri M

    更新日期:2021-01-28 00:00:00

  • Young-onset colorectal cancer risk among individuals with iron-deficiency anaemia and haematochezia.

    abstract:OBJECTIVE:Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC. DESIGN:Cohort study of US Veterans aged 18-...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321849

    authors: Demb J,Liu L,Murphy CC,Doubeni CA,Martínez ME,Gupta S

    更新日期:2020-12-18 00:00:00

  • The influence of proton pump inhibitor therapy on the outcome of infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies.

    abstract:OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321609

    authors: Lu TX,Dapas M,Lin E,Peters T,Sakuraba A

    更新日期:2020-12-17 00:00:00

  • Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.

    abstract:OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322779

    authors: Matsuo J,Douchi D,Myint K,Mon NN,Yamamura A,Kohu K,Heng DL,Chen S,Mawan NA,Nuttonmanit N,Li Y,Srivastava S,Ho SWT,Lee NYS,Lee HK,Adachi M,Tamura A,Chen J,Yang H,Teh M,So JB,Yong WP,Tan P,Yeoh KG,Chuang LSH

    更新日期:2020-12-08 00:00:00

  • Substantial and sustained improvement of serrated polyp detection after a simple educational intervention: results from a prospective controlled trial.

    abstract:OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319804

    authors: Bleijenberg AGC,van Leerdam ME,Bargeman M,Koornstra JJ,van Herwaarden YJ,Spaander MC,Sanduleanu S,Bastiaansen BAJ,Schoon EJ,van Lelyveld N,Dekker E,IJspeert JEG

    更新日期:2020-12-01 00:00:00

  • Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study.

    abstract:OBJECTIVE:Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. DESIGN:Through analysis of...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-320007

    authors: Hutchinson SJ,Valerio H,McDonald SA,Yeung A,Pollock K,Smith S,Barclay S,Dillon JF,Fox R,Bramley P,Fraser A,Kennedy N,Gunson RN,Templeton K,Innes H,McLeod A,Weir A,Hayes PC,Goldberg D

    更新日期:2020-12-01 00:00:00

  • Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis.

    abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320839

    authors: Ford AC,Yuan Y,Moayyedi P

    更新日期:2020-12-01 00:00:00

  • Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function.

    abstract:OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322753

    authors: Frost F,Kacprowski T,Rühlemann M,Pietzner M,Bang C,Franke A,Nauck M,Völker U,Völzke H,Dörr M,Baumbach J,Sendler M,Schulz C,Mayerle J,Weiss FU,Homuth G,Lerch MM

    更新日期:2020-11-09 00:00:00

  • Machine learning in GI endoscopy: practical guidance in how to interpret a novel field.

    abstract::There has been a vast increase in GI literature focused on the use of machine learning in endoscopy. The relative novelty of this field poses a challenge for reviewers and readers of GI journals. To appreciate scientific quality and novelty of machine learning studies, understanding of the technical basis and commonly...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2019-320466

    authors: van der Sommen F,de Groof J,Struyvenberg M,van der Putten J,Boers T,Fockens K,Schoon EJ,Curvers W,de With P,Mori Y,Byrne M,Bergman JJGHM

    更新日期:2020-11-01 00:00:00

  • Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity.

    abstract:OBJECTIVE:Non-coeliac gluten sensitivity (NCGS) is characterised by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing foods, in the absence of coeliac disease (CD) and wheat allergy. No biomarkers are available to diagnose NCGS and the gold standard double-blind placebo-controlled gl...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319281

    authors: Barbaro MR,Cremon C,Morselli-Labate AM,Di Sabatino A,Giuffrida P,Corazza GR,Di Stefano M,Caio G,Latella G,Ciacci C,Fuschi D,Mastroroberto M,Bellacosa L,Stanghellini V,Volta U,Barbara G

    更新日期:2020-11-01 00:00:00

  • Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.

    abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320608

    authors: Sano M,Takahashi R,Ijichi H,Ishigaki K,Yamada T,Miyabayashi K,Kimura G,Mizuno S,Kato H,Fujiwara H,Nakatsuka T,Tanaka Y,Kim J,Masugi Y,Morishita Y,Tanaka M,Ushiku T,Nakai Y,Tateishi K,Ishii Y,Isayama H,Moses HL,

    更新日期:2020-10-21 00:00:00

  • Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health.

    abstract::The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. It varies among individuals and depends on host genotype and environmental factors, such as diet and antibiotics. In this review, we focus on stability and resilience as essential ecological characteristics of the gut...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2020-321747

    authors: Fassarella M,Blaak EE,Penders J,Nauta A,Smidt H,Zoetendal EG

    更新日期:2020-10-13 00:00:00

  • Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource.

    abstract:OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-320185

    authors: Stournaras E,Qian W,Pappas A,Hong YY,Shawky R,UK IBD BioResource Investigators.,Raine T,Parkes M,UK IBD Bioresource Investigators.

    更新日期:2020-10-01 00:00:00

  • Comparison of the Rome IV criteria with the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care.

    abstract:OBJECTIVES:Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. DESIGN:We collected complete symptom data from co...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322519

    authors: Black CJ,Craig O,Gracie DJ,Ford AC

    更新日期:2020-09-24 00:00:00

  • TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

    abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2 (TREM-2) is predominantly expressed in hepatic non-parenchymal cells and i...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319227

    authors: Esparza-Baquer A,Labiano I,Sharif O,Agirre-Lizaso A,Oakley F,Rodrigues PM,Zhuravleva E,O'Rourke CJ,Hijona E,Jimenez-Agüero R,Riaño I,Landa A,La Casta A,Zaki MYW,Munoz-Garrido P,Azkargorta M,Elortza F,Vogel A,Schabbaue

    更新日期:2020-09-09 00:00:00

  • Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice.

    abstract:OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319693

    authors: Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

    更新日期:2020-09-01 00:00:00

  • Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn's disease: results from two large prospective cohort studies.

    abstract:OBJECTIVE:To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC). DESIGN:We conducted a prospective cohort study of 83 147 participants (age range: 45-79 years) enrolled in the Cohort of Swedish Men and Swedish Mammography Cohort. A validated food...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319505

    authors: Khalili H,Håkansson N,Chan SS,Chen Y,Lochhead P,Ludvigsson JF,Chan AT,Hart AR,Olén O,Wolk A

    更新日期:2020-09-01 00:00:00

  • USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis.

    abstract:OBJECTIVE:Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-me...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-318640

    authors: Costa L,Corre S,Michel V,Le Luel K,Fernandes J,Ziveri J,Jouvion G,Danckaert A,Mouchet N,Da Silva Barreira D,Torres J,Camorlinga M,D'Elios MM,Fiette L,De Reuse H,Galibert MD,Touati E

    更新日期:2020-09-01 00:00:00

  • CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer.

    abstract:OBJECTIVE:Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal adenocarcinoma cancer (PDAC). DESIGN:We screened 429 kinase inhibitors for ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-320441

    authors: Huang J,Chen P,Liu K,Liu J,Zhou B,Wu R,Peng Q,Liu ZX,Li C,Kroemer G,Lotze M,Zeh H,Kang R,Tang D

    更新日期:2020-08-14 00:00:00

  • Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation.

    abstract:BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321116

    authors: Seto WK,Liu KS,Mak LY,Cloherty G,Wong DK,Gersch J,Lam YF,Cheung KS,Chow N,Ko KL,To WP,Fung J,Yuen MF

    更新日期:2020-08-05 00:00:00

  • Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis.

    abstract:OBJECTIVES:National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this unce...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321191

    authors: Black CJ,Thakur ER,Houghton LA,Quigley EMM,Moayyedi P,Ford AC

    更新日期:2020-08-01 00:00:00

  • Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology.

    abstract::Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy but predominantly percutaneous or transvenous approaches are used. A wide choice of needles ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321299

    authors: Neuberger J,Patel J,Caldwell H,Davies S,Hebditch V,Hollywood C,Hubscher S,Karkhanis S,Lester W,Roslund N,West R,Wyatt JI,Heydtmann M

    更新日期:2020-08-01 00:00:00

  • Global prevalence of Barrett's oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal re...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321365

    authors: Eusebi LH,Cirota GG,Zagari RM,Ford AC

    更新日期:2020-07-30 00:00:00

  • Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa.

    abstract:OBJECTIVE:Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320946

    authors: Reyes-Uribe L,Wu W,Gelincik O,Bommi PV,Francisco-Cruz A,Solis LM,Lynch PM,Lim R,Stoffel EM,Kanth P,Samadder NJ,Mork ME,Taggart MW,Milne GL,Marnett LJ,Vornik L,Liu DD,Revuelta M,Chang K,You YN,Kopelovich L,Wistub

    更新日期:2020-07-08 00:00:00

  • Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation.

    abstract:OBJECTIVE:Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused on short-chain fatty acids produced by gut microbiota. Ginseng has been reported to aid in body weight management, however, its mechanism of action is not yet clear. In this study, we focused on the potential m...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319114

    authors: Quan LH,Zhang C,Dong M,Jiang J,Xu H,Yan C,Liu X,Zhou H,Zhang H,Chen L,Zhong FL,Luo ZB,Lam SM,Shui G,Li D,Jin W

    更新日期:2020-07-01 00:00:00

  • Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study.

    abstract:OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321411

    authors: Bezzio C,Saibeni S,Variola A,Allocca M,Massari A,Gerardi V,Casini V,Ricci C,Zingone F,Amato A,Caprioli F,Lenti MV,Viganò C,Ascolani M,Bossa F,Castiglione F,Cortelezzi C,Grossi L,Milla M,Morganti D,Pastorelli L,R

    更新日期:2020-07-01 00:00:00

  • Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium.

    abstract:OBJECTIVE:The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in innate immune signalling pathways is associated with severe inflammatory diseases, but the responsiveness of GI epithelial cells to bacterial stimulation remains unclear. DESIGN:We gene...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319919

    authors: Kayisoglu O,Weiss F,Niklas C,Pierotti I,Pompaiah M,Wallaschek N,Germer CT,Wiegering A,Bartfeld S

    更新日期:2020-06-22 00:00:00

  • Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.

    abstract:OBJECTIVE:Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC. DESIGN:This retrospe...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319926

    authors: Hatta W,Tsuji Y,Yoshio T,Kakushima N,Hoteya S,Doyama H,Nagami Y,Hikichi T,Kobayashi M,Morita Y,Sumiyoshi T,Iguchi M,Tomida H,Inoue T,Koike T,Mikami T,Hasatani K,Nishikawa J,Matsumura T,Nebiki H,Nakamatsu D,Ohnit

    更新日期:2020-06-04 00:00:00

  • Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells.

    abstract:OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-318812

    authors: Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

    更新日期:2020-06-01 00:00:00

  • Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure.

    abstract:OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319960

    authors: Yang H,Sun L,Pang Y,Hu D,Xu H,Mao S,Peng W,Wang Y,Xu Y,Zheng YC,Du S,Zhao H,Chi T,Lu X,Sang X,Zhong S,Wang X,Zhang H,Huang P,Sun W,Mao Y

    更新日期:2020-05-20 00:00:00

  • Histopathologist features predictive of diagnostic concordance at expert level among a large international sample of pathologists diagnosing Barrett's dysplasia using digital pathology.

    abstract:OBJECTIVE:Guidelines mandate expert pathology review of Barrett's oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance. DESIGN:Pathologists (n=5...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究

    doi:10.1136/gutjnl-2019-318985

    authors: van der Wel MJ,Coleman HG,Bergman JJGHM,Jansen M,Meijer SL,BOLERO working group.

    更新日期:2020-05-01 00:00:00

  • microRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility.

    abstract:OBJECTIVE:This study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC). DESIGN:All human tissue samples were from the muscularis externa of the colon. Expression of 372 miRNAs was examined in a discovery cohort of four patients with STC versus three age/sex-matched controls by...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-318747

    authors: Mazzone A,Strege PR,Gibbons SJ,Alcaino C,Joshi V,Haak AJ,Tschumperlin DJ,Bernard CE,Cima RR,Larson DW,Chua HK,Graham RP,El Refaey M,Mohler PJ,Hayashi Y,Ordog T,Calder S,Du P,Farrugia G,Beyder A

    更新日期:2020-05-01 00:00:00

  • Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.

    abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI tumour, and it possesses deregulated cellular energetics. Although recent advances in PDAC biology have led to the discovery of recurrent genetic mutations in Kras, TP53 and SMAD4, which are related to this disease, clinical application...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2018-317163

    authors: Liang C,Shi S,Qin Y,Meng Q,Hua J,Hu Q,Ji S,Zhang B,Xu J,Yu XJ

    更新日期:2020-05-01 00:00:00

  • Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations.

    abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE:To develop a set of multidisciplinary recommenda...

    journal_title:Gut

    pub_type: 杂志文章,实务指引

    doi:10.1136/gutjnl-2019-319300

    authors: Szeto CC,Sugano K,Wang JG,Fujimoto K,Whittle S,Modi GK,Chen CH,Park JB,Tam LS,Vareesangthip K,Tsoi KKF,Chan FKL

    更新日期:2020-04-01 00:00:00

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