Global prevalence of Barrett's oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.

Abstract:

OBJECTIVES:Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux. DESIGN:We searched MEDLINE, Embase and Embase Classic to identify cross-sectional surveys that reported prevalence of BO or oesophageal adenocarcinoma in adults with gastro-oesophageal reflux. We extracted prevalence for all studies, both for endoscopically suspected and histologically confirmed cases. We calculated pooled prevalence according to study location, symptom frequency and sex, as well as ORs with 95% CIs. RESULTS:Of the 4963 citations evaluated, 44 reported prevalence of endoscopically suspected and/or histologically confirmed BO. Prevalence of BO among individuals with gastro-oesophageal reflux varied according to different geographical regions ranging from 3% to 14% for histologically confirmed BO with a pooled prevalence of 7.2% (95% CI 5.4% to 9.3%), whereas pooled prevalence for endoscopically suspected BO was 12.0% (95% CI 5.5% to 20.3%). There was heterogeneity in many of our analyses. Prevalence of BO was significantly higher in men, both for endoscopically suspected (OR=2.1; 95% CI 1.6 to 2.8) and histologically confirmed BO (OR=2.3; 95% CI 1.7 to 3.2). Dysplasia was present in 13.9% (95% CI 8.9% to 19.8%) of cases of histologically confirmed BO, 80.7% of which was low-grade. CONCLUSION:The prevalence of Barrett's oesophagus among individuals with gastro-oesophageal reflux varied strikingly among countries, broadly resembling the geographical distribution of gastro-oesophageal reflux itself. Prevalence of BO was significantly higher in men.

journal_name

Gut

journal_title

Gut

authors

Eusebi LH,Cirota GG,Zagari RM,Ford AC

doi

10.1136/gutjnl-2020-321365

subject

Has Abstract

pub_date

2020-07-30 00:00:00

eissn

0017-5749

issn

1468-3288

pii

gutjnl-2020-321365

pub_type

杂志文章

相关文献

GUT文献大全
  • GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

    abstract:BACKGROUND AND AIMS:The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of tumours and was proposed to be oncogenic, but high GATA6 levels are found in well-differentiated tumou...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-311256

    authors: Martinelli P,Carrillo-de Santa Pau E,Cox T,Sainz B Jr,Dusetti N,Greenhalf W,Rinaldi L,Costello E,Ghaneh P,Malats N,Büchler M,Pajic M,Biankin AV,Iovanna J,Neoptolemos J,Real FX

    更新日期:2017-09-01 00:00:00

  • Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles.

    abstract:BACKGROUND:The normal intestinal microflora plays an important role in host metabolism and provides a natural defence mechanism against invading pathogens. Although the microbiota in adults has been extensively studied, little is known of the changes that occur in the microflora with aging. These may have important con...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.2.198

    authors: Hopkins MJ,Sharp R,Macfarlane GT

    更新日期:2001-02-01 00:00:00

  • U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients.

    abstract::These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309262

    authors: Tripathi D,Stanley AJ,Hayes PC,Patch D,Millson C,Mehrzad H,Austin A,Ferguson JW,Olliff SP,Hudson M,Christie JM,Clinical Services and Standards Committee of the British Society of Gastroenterology.

    更新日期:2015-11-01 00:00:00

  • After portal branch ligation in the rat, cellular proliferation is associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2.

    abstract:BACKGROUND:In liver regeneration after portal branch ligation we previously showed that early cellular changes are observed in both the proliferating and atrophying liver lobes. They are therefore not indicative of future proliferative response. In this study we attempted to define precisely, in the same model, the tim...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.49.1.119

    authors: Stärkel P,Lambotte L,Sempoux C,De Saeger C,Saliez A,Maiter D,Horsmans Y

    更新日期:2001-07-01 00:00:00

  • Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats.

    abstract:BACKGROUND:Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS:To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS:Wistar rats, aged eight weeks, underwent 60% proximal resection or transection ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.45.1.89

    authors: Buts JP,De Keyser N,Marandi S,Hermans D,Sokal EM,Chae YH,Lambotte L,Chanteux H,Tulkens PM

    更新日期:1999-07-01 00:00:00

  • Mechanism and specificity of increased amylase/creatinine clearance ratio in pancreatitis.

    abstract::The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.18.9.703

    authors: Marten A,Beales D,Elias E

    更新日期:1977-09-01 00:00:00

  • Genetically related Escherichia coli strains associated with Crohn's disease.

    abstract::Escherichia coli strains isolated from patients with Crohn's disease (CD) with chronic ileal lesions (n=14), early endoscopic recurrent lesions (n=20), without endoscopic recurrence (n=7), and controls (n=21) were compared by ribotyping. The dendrogram generated by 50 ribotype profile analysis revealed a large cluster...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.3.320

    authors: Masseret E,Boudeau J,Colombel JF,Neut C,Desreumaux P,Joly B,Cortot A,Darfeuille-Michaud A

    更新日期:2001-03-01 00:00:00

  • Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines.

    abstract::Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. The in vitro expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on biliary epithelial cells was studied in response...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.9.1245

    authors: Ayres RC,Neuberger JM,Shaw J,Joplin R,Adams DH

    更新日期:1993-09-01 00:00:00

  • Undetectable caeruloplasmin values in a patient with autoimmune chronic active hepatitis.

    abstract::Caeruloplasmin is an alpha 2 protein produced in the liver that is responsible for transporting copper in the blood. Caeruloplasmin values are usually high in patients with chronic liver diseases, including chronic active hepatitis: low values, however, are characteristic of Wilson's disease. The case of a 17 year old...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.5.549

    authors: Ilan Y,Hillman M,Oren R,Galun E,Shalit M

    更新日期:1991-05-01 00:00:00

  • Profile of Helicobacter pylori cytotoxin derived from two areas of Japan with different prevalence of atrophic gastritis.

    abstract:BACKGROUND AND AIM:To clarify the roles of Helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in Fukui and Okinawa, where the prevalence of atrophic gastritis and gastric cancer risk are quite different, were studied. MATERIALS:Seventy three strains from Fukui and 51 f...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.39.6.800

    authors: Ito S,Azuma T,Murakita H,Hirai M,Miyaji H,Ito Y,Ohtaki Y,Yamazaki Y,Kuriyama M,Keida Y,Kohli Y

    更新日期:1996-12-01 00:00:00

  • Experience with a gastrointestinal marker (51CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoB12 measured by whole body counting.

    abstract::Introduction of a radioactive gastrointestinal marker (51CrCl3) into a combined study (75SeHCAT + 58CoB12) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid ar...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.10.1120

    authors: Smith T,Bjarnason I

    更新日期:1990-10-01 00:00:00

  • Histological appearances of oesophagus, antrum and duodenum and their correlation with symptoms in patients with a duodenal ulcer.

    abstract::Clinical data and histology from the oesophagus, gastric antrum, and duodenum were collected from 36 patients undergoing surgery for duodenal ulcer. Gastritis was present in 94% of the patients (25% of atrophic type), oesophagitis in 72% and duodenitis in 39%. Abnormal biopsies were present from all three sites in 33%...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.1.95

    authors: Earlam RJ,Amerigo J,Kakavoulis T,Pollock DJ

    更新日期:1985-01-01 00:00:00

  • Levofloxacin-based and clarithromycin-based triple therapies as first-line and second-line treatments for Helicobacter pylori infection: a randomised comparative trial with crossover design.

    abstract:BACKGROUND:The efficacy of a levofloxacin-based regimen as the first-line treatment and a clarithromycin-based regimen as the second-line treatment for Helicobacter pylori infection remains unknown. The aim of this study was to assess the eradication rates of these two regimens using different administration sequences....

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2009.198309

    authors: Liou JM,Lin JT,Chang CY,Chen MJ,Cheng TY,Lee YC,Chen CC,Sheng WH,Wang HP,Wu MS

    更新日期:2010-05-01 00:00:00

  • Comparison of the Rome IV criteria with the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care.

    abstract:OBJECTIVES:Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. DESIGN:We collected complete symptom data from co...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322519

    authors: Black CJ,Craig O,Gracie DJ,Ford AC

    更新日期:2020-09-24 00:00:00

  • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C.

    abstract:BACKGROUND:Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS:The aim of the present...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.050302

    authors: Fartoux L,Poujol-Robert A,Guéchot J,Wendum D,Poupon R,Serfaty L

    更新日期:2005-07-01 00:00:00

  • Pelvic floor neuropathy: a comparative study of diabetes mellitus and idiopathic faecal incontinence.

    abstract::Twenty one patients with diabetic peripheral neuropathy, 18 with idiopathic faecal incontinence and 11 normal controls were studied with techniques of mucosal electrosensitivity, rectal distension for the quantitative assessment of anorectal sensation, and manometric and electromyographic tests for the assessment of a...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.6.756

    authors: Rogers J,Levy DM,Henry MM,Misiewicz JJ

    更新日期:1988-06-01 00:00:00

  • Ulcerative colitis in the United States Army in 1944. Follow-up with particular reference to mortality in cases and controls.

    abstract::This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.4.2.183

    authors: NEFZGER MD,ACHESON ED

    更新日期:1963-06-01 00:00:00

  • A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia. GISMAD Achalasia Study Group.

    abstract:BACKGROUND:Intrasphincteric injection of botulinum toxin (Botx) has been proposed as treatment for oesophageal achalasia. However, the predictors of response and optimal dose remain unclear. AIMS:To compare the effect of different doses of Botx and to identify predictors of response. PATIENTS/METHODS:A total of 118 a...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.46.5.597

    authors: Annese V,Bassotti G,Coccia G,Dinelli M,D'Onofrio V,Gatto G,Leandro G,Repici A,Testoni PA,Andriulli A

    更新日期:2000-05-01 00:00:00

  • Impaired transforming growth factor beta signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation.

    abstract:BACKGROUND AND AIMS:Transforming growth factor beta (TGF-beta) is frequently involved in gastrointestinal carcinogenesis although its contribution to oesophageal adenocarcinoma (AC) and its precursor Barrett's oesophageal epithelium (BE) metaplasia are unclear. METHODS:Expression of TGF-beta signalling components was ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.076430

    authors: Onwuegbusi BA,Aitchison A,Chin SF,Kranjac T,Mills I,Huang Y,Lao-Sirieix P,Caldas C,Fitzgerald RC

    更新日期:2006-06-01 00:00:00

  • Pressure and frequency dependent linkage between motility and epithelial secretion in human proximal small intestine.

    abstract:BACKGROUND:Motor disturbances are sometimes associated with diarrhoea by unknown mechanisms. AIM:To determine if there is a quantitative link between intestinal motility and epithelial secretion. SUBJECTS:Experiments were performed in 21 healthy volunteers and three patients with villus atrophy. METHODS:Duodenal and...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.46.3.376

    authors: Mellander A,Järbur K,Sjövall H

    更新日期:2000-03-01 00:00:00

  • Drug metabolism in hepatosplenic schistosomiasis in the Sudan: a study with antipyrine.

    abstract::The disposition of antipyrine following oral administration of 1200 mg has been investigated in 10 patients with histologically confirmed hepatosplenic schistosomiasis and 11 normal subjects living in Sudan. Drug metabolising activity as assessed by antipyrine clearance was similar in patients when compared with norma...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.19.9.808

    authors: Homeida M,Salih SY,Branch RA

    更新日期:1978-09-01 00:00:00

  • The relation of sensation in the anal canal to the functional anal sphincter: a possible factor in anal continence.

    abstract::In normal subjects the length of the functional anal sphincter has been compared with the extent of sensation to light touch in the anal canal. At rest, the sphincteric zone was the longer. On distension of the rectum, a decrease in pressure in the anal canal so shortened the functional sphincter that intrarectal pres...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.4.2.179

    authors: Duthie HL,Bennett RC

    更新日期:1963-06-01 00:00:00

  • Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.

    abstract:OBJECTIVE:Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC. DESIGN:This retrospe...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319926

    authors: Hatta W,Tsuji Y,Yoshio T,Kakushima N,Hoteya S,Doyama H,Nagami Y,Hikichi T,Kobayashi M,Morita Y,Sumiyoshi T,Iguchi M,Tomida H,Inoue T,Koike T,Mikami T,Hasatani K,Nishikawa J,Matsumura T,Nebiki H,Nakamatsu D,Ohnit

    更新日期:2020-06-04 00:00:00

  • Inhibitory effect of a cholecystokinin antagonist on the proliferative response of the pancreas to pancreatobiliary diversion.

    abstract::Since pancreatobiliary diversion probably stimulates pancreatic growth by increasing cholecystokinin secretion, the effect of the cholecystokinin antagonist CR-1409 on this adaptive response was tested. Male Wistar rats (n = 108) weighing 220-250g were randomised to receive either pancreatobiliary diversion (n = 60) o...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.9.1049

    authors: Watanapa P,Efa EF,Beardshall K,Calam J,Sarraf CE,Alison MR,Williamson RC

    更新日期:1991-09-01 00:00:00

  • Effects of appendicectomy on the course of ulcerative colitis.

    abstract:BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were sp...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.51.6.803

    authors: Cosnes J,Carbonnel F,Beaugerie L,Blain A,Reijasse D,Gendre JP

    更新日期:2002-12-01 00:00:00

  • The action of secretin and pancreozymin on small-intestinal alkaline phosphatase.

    abstract::The hormones secretin and cholecystokinin-pancreozymin (CCK) have been shown to release brush-border alkaline phosphatase into the small-intestinal lumen in the human subject. In contrast to the disaccharidases, large amounts of alkaline phosphatase are present in human duodenal juice. The range has been established i...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.15.1.39

    authors: Warnes TW,Hine P,Kay G

    更新日期:1974-01-01 00:00:00

  • Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9.

    abstract:BACKGROUND:The phenotypic spectrum of familial adenomatous polyposis (FAP) varies from the classic appearance of hundreds of adenomatous colonic polyps in the young adult and early onset colorectal cancer, to the occurrence of sparse adenomas in the older adult, "attenuated" FAP, due to mutations at the 5' or 3' ends o...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.45.6.829

    authors: Rozen P,Samuel Z,Shomrat R,Legum C

    更新日期:1999-12-01 00:00:00

  • Small intestinal structure and passive permeability in systemic sclerosis.

    abstract::Seventeen patients with proven systemic sclerosis had a peroral jejunal biopsy performed. Four biopsies were regarded as showing abnormalities, which were mostly confined to the deeper structures, although in two there was a minimal degree of villous atrophy without epithelial cell changes. Passive intestinal permeabi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.4.293

    authors: Cobden I,Rothwell J,Axon AT,Dixon MF,Lintott DJ,Rowell NR

    更新日期:1980-04-01 00:00:00

  • Signals from dying hepatocytes trigger growth of liver progenitors.

    abstract:OBJECTIVE:The death rate of mature hepatocytes is chronically increased in various liver diseases, triggering responses that prevent liver atrophy, but often cause fibrosis. Mice with targeted disruption of inhibitor kappa B kinase (Ikk) in hepatocytes (HEP mice) provide a model to investigate this process because inhi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2009.204354

    authors: Jung Y,Witek RP,Syn WK,Choi SS,Omenetti A,Premont R,Guy CD,Diehl AM

    更新日期:2010-05-01 00:00:00

  • Endotoxaemia and complement activation in acute pancreatitis in man.

    abstract::Twenty-four patients who experienced 26 attacks of acute pancreatitis were studied. Endotoxaemia, as measured by the limulus lysate assay, was present in 13 of the attacks. Six out of seven patients with systemic complications of the disease had endotoxaemia. C3 catabolism was increased in all 26 attacks of pancreatit...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.23.8.656

    authors: Foulis AK,Murray WR,Galloway D,McCartney AC,Lang E,Veitch J,Whaley K

    更新日期:1982-08-01 00:00:00