Endoscopy and central reading in inflammatory bowel disease clinical trials: achievements, challenges and future developments.

abstract：:Serum samples from 26 monozygotic twin pairs concordant or discordant with regard to inflammatory bowel disease, and rectal biopsies from 42 twins of the same subject group, were examined for IgG subclasses. They were all compared with normal controls. Almost all affected twins were in clinical remission. Paired immun...

journal_title：Gut

authors： Helgeland L,Tysk C,Järnerot G,Kett K,Lindberg E,Danielsson D,Andersen SN,Brandtzaeg P

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...

journal_title：Gut

authors： Yang H,Sun L,Pang Y,Hu D,Xu H,Mao S,Peng W,Wang Y,Xu Y,Zheng YC,Du S,Zhao H,Chi T,Lu X,Sang X,Zhong S,Wang X,Zhang H,Huang P,Sun W,Mao Y

更新日期：2020-05-20 00:00:00

abstract：:Increased concentrations of the soluble form of the interleukin 2 receptor have been observed in the sera of Crohn's disease and ulcerative colitis patients. In this study we have observed the spontaneous release of soluble interleukin 2 receptor by unstimulated, isolated normal and inflammatory bowel disease colonic ...

journal_title：Gut

authors： Schreiber S,Raedler A,Conn AR,Rombeau JL,MacDermott RP

更新日期：1992-02-01 00:00:00

abstract：:Stimulation of the rectal mucosa with a bipolar electrode leads to relaxation of the internal anal sphincter. Intraoperative studies in two subjects showed that transmission of the impulse was independent of extrinsic nerves and was interrupted by circular myotomy. Characteristics of the reflex were studied in 11 heal...

journal_title：Gut

authors： Kamm MA,Lennard-Jones JE,Nicholls RJ

更新日期：1989-07-01 00:00:00

abstract：:Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...

journal_title：Gut

authors： Osborne DH,Lennon J,Henderson M,Lidgard G,Creel R,Carter DC

更新日期：1977-02-01 00:00:00

abstract：:The metabolism of pure radioiodine labelled Clq has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional catabolic rate and the synthesis rate of Clq were increased in the five patients with Crohn's disease and in four of the five...

journal_title：Gut

authors： Potter BJ,Hodgson HJ,Mee AS,Jewell DP

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:In liver regeneration after portal branch ligation we previously showed that early cellular changes are observed in both the proliferating and atrophying liver lobes. They are therefore not indicative of future proliferative response. In this study we attempted to define precisely, in the same model, the tim...

journal_title：Gut

authors： Stärkel P,Lambotte L,Sempoux C,De Saeger C,Saliez A,Maiter D,Horsmans Y

更新日期：2001-07-01 00:00:00

abstract：:The thoracic duct was cannulated in six patients who were actively bleeding from varices and had not responded to conservative treatment but draining lymph from the thoracic duct did not control bleeding in five patients. There was no drop in intrasplenic pulp pressure following this procedure when recorded in three o...

journal_title：Gut

authors： Datta DV,Singh SA,Patra BS,Saini VK,Chhuttani PN

更新日期：1971-01-01 00:00:00

abstract：:Bacterial contamination of gastrointestinal fibre-endoscopes is a potential source of clinically significant infection. Aqueous 2% alkaline glutaraldehyde adequately disinfects fibre-endoscopes but may cause serious sensitivity reactions among endoscopy staff. A new 'closed-system' disinfecting apparatus is described ...

journal_title：Gut

authors： O'Connor HJ,Rothwell J,Maxwell S,Lincoln C,Axon AT

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:The molecular mechanisms mediating the antiproliferative effects of interferon alpha on human pancreatic carcinoma cells are poorly understood. AIM:To characterise the effects of interferon alpha on protein kinase C isoenzyme expression in interferon alpha sensitive and resistant human pancreatic tumour cel...

journal_title：Gut

authors： Rosewicz S,Weder M,Kaiser A,Riecken EO

更新日期：1996-08-01 00:00:00

abstract：:All patients presenting with acute upper gastrointestinal bleeding between November 1986 and April 1988 were admitted to a centralised joint medical/surgical unit, with a policy of early clinical and endoscopic assessment and rapid surgical intervention in those at high risk. Of the 430 patients admitted 69.5% were ov...

journal_title：Gut

authors： Holman RA,Davis M,Gough KR,Gartell P,Britton DC,Smith RB

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVES:Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal re...

journal_title：Gut

authors： Eusebi LH,Cirota GG,Zagari RM,Ford AC

更新日期：2020-07-30 00:00:00

abstract：OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...

journal_title：Gut

authors： Wan L,Yu W,Shen E,Sun W,Liu Y,Kong J,Wu Y,Han F,Zhang L,Yu T,Zhou Y,Xie S,Xu E,Zhang H,Lai M

更新日期：2019-01-01 00:00:00

abstract：:The value of the bipolar electrocoagulator in the haemostasis of bleeding ulcers is controversial. We have therefore investigated the effect of different coagulation times on vessel weld strength achieved by the bipolar device. Welds were then made in vessels of known diameter using a standard 10F endoscopic haemostat...

journal_title：Gut

authors： Harrison JD,Morris DL

更新日期：1991-02-01 00:00:00

abstract：:Two patients who developed biochemical and histological evidence of hepatitis while taking the anti-anginal drug perhexiline maleate are described. The pathological changes were those of mild to moderate fatty change together with a hepatitis which resembled alcoholic hepatitis, including in one patient the presence o...

journal_title：Gut

authors： Lewis D,Wainwright HC,Kew MC,Zwi S,Isaacson C

更新日期：1979-03-01 00:00:00

abstract：:The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...

journal_title：Gut

authors： Narducci F,Bassotti G,Gaburri M,Morelli A

更新日期：1987-01-01 00:00:00

abstract：:A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...

journal_title：Gut

authors： Ludvigsson JF,Bai JC,Biagi F,Card TR,Ciacci C,Ciclitira PJ,Green PH,Hadjivassiliou M,Holdoway A,van Heel DA,Kaukinen K,Leffler DA,Leonard JN,Lundin KE,McGough N,Davidson M,Murray JA,Swift GL,Walker MM,Zingone F,Sa

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

journal_title：Gut

authors： de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

更新日期：2007-12-01 00:00:00

abstract：:Carriers of beta amino acids and imino acids in the small intestine of rabbits and guinea pigs are chloride dependent, and a cotransport of chloride, sodium, and 2-methyl-aminoisobutyric acid has been shown. This study examines the chloride dependence of amino acid transport in the human small intestine. The steady st...

journal_title：Gut

authors： Munck LK

更新日期：1995-02-01 00:00:00

abstract：:Salivary amylase output in man increases after injection of synthetic human calcitonin. This effect is dose dependent. ...

journal_title：Gut

authors： Drack GT,Koelz HR,Blum AL

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2 (TREM-2) is predominantly expressed in hepatic non-parenchymal cells and i...

journal_title：Gut

authors： Esparza-Baquer A,Labiano I,Sharif O,Agirre-Lizaso A,Oakley F,Rodrigues PM,Zhuravleva E,O'Rourke CJ,Hijona E,Jimenez-Agüero R,Riaño I,Landa A,La Casta A,Zaki MYW,Munoz-Garrido P,Azkargorta M,Elortza F,Vogel A,Schabbaue

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Colonoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) reduces death rates, but early interval cancers still occur, probably due to missed small, aggressive adenomas. Narrow band imaging (NBI), a novel endoscopic technology, highlights superficial mucosal capillaries and improves co...

journal_title：Gut

authors： East JE,Suzuki N,Stavrinidis M,Guenther T,Thomas HJ,Saunders BP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Caroli's disease is a rare congenital disorder characterised by cystic dilatation of the intrahepatic bile ducts and an increased risk of cholangiocellular carcinoma. The cause is unknown, but occasional familial clustering suggests that some cases are inherited, in particular when occurring in association w...

journal_title：Gut

authors： Parada LA,Hallén M,Hägerstrand I,Tranberg KG,Johansson B

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...

journal_title：Gut

authors： Jung D,Fantin AC,Scheurer U,Fried M,Kullak-Ublick GA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptib...

journal_title：Gut

authors： Noble CL,Nimmo ER,Drummond H,Smith L,Arnott ID,Satsangi J

更新日期：2005-10-01 00:00:00

abstract：:The size of the related lymph nodes and their histology has been correlated in 34 specimens of Crohn's disease. Granulomata were shown not to affect the maximum diameter of the lymph nodes nor to be more frequent in large nodes. The enlargement of lymph nodes appeared to be due to simple, non-specific, reactive change...

journal_title：Gut

authors： Cook MG

更新日期：1972-12-01 00:00:00

abstract：BACKGROUND:The ground squirrel on a high cholesterol diet exhibits prolonged intestinal transit, a pathogenetic factor in cholesterol gallstone formation. AIMS:To examine the effect of a high cholesterol diet on the characteristics of the migrating myoelectrical complex (MMC) and the potential benefit of erythromycin....

journal_title：Gut

authors： Xu QW,Scott RB,Tan DT,Shaffer EA

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Shanghai fever, a community-acquired enteric illness associated with sepsis caused by Pseudomonas aeruginosa, was first described in 1918. The understanding of Shanghai fever is incomplete. OBJECTIVE:To delineate the clinical features and to examine the host and microbial factors associated with Shanghai fe...

journal_title：Gut

authors： Chuang CH,Wang YH,Chang HJ,Chen HL,Huang YC,Lin TY,Ozer EA,Allen JP,Hauser AR,Chiu CH

更新日期：2014-05-01 00:00:00

abstract：AIM:To compare acceptability and diagnostic accuracy of a recently available faecal immunochemical test (FIT) system (HM-JACKarc) with the FIT routinely used in an established screening programme (OC-Sensor). DESIGN:Randomised controlled trial (ISRCTN20086618) within a population-based colorectal cancer (CRC) screenin...

journal_title：Gut

authors： Passamonti B,Malaspina M,Fraser CG,Tintori B,Carlani A,D'Angelo V,Galeazzi P,Di Dato E,Mariotti L,Bulletti S,D'Amico MR,Gustinucci D,Martinelli N,Spita N,Cesarini E,Rubeca T,Giaimo M,Segnan N,Senore C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Suicide gene therapy consists of the transfer into tumour cells of a "suicide" gene that can convert a non-toxic compound into a lethal drug. Expression of the cytosine deaminase gene leads to the conversion of the non-toxic compound 5-fluorocytosine to 5-fluorouracil. We have recently shown that "suicide ce...

journal_title：Gut

authors： Pierrefite-Carle V,Baqué P,Gavelli A,Brossette N,Benchimol D,Bourgeon A,Saint Paul MC,Staccini P,Rossi B

更新日期：2002-03-01 00:00:00