Abstract:
OBJECTIVE:Non-coeliac gluten sensitivity (NCGS) is characterised by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing foods, in the absence of coeliac disease (CD) and wheat allergy. No biomarkers are available to diagnose NCGS and the gold standard double-blind placebo-controlled gluten challenge is clinically impractical. The aim of our work was to investigate the role of serum zonulin as a diagnostic biomarker of NCGS and to develop a diagnostic algorithm. DESIGN:In a multicentre study, we enrolled 86 patients with either self-reported or double-blind confirmed NCGS, 59 patients with diarrhoea-predominant IBS (IBS-D), 15 patients with CD and 25 asymptomatic controls (AC). Zonulin serum levels were assessed and the associated diagnostic power calculated. Clinical and symptomatic data were recorded. The effect of diet on zonulin levels was evaluated in a subgroup of patients with NCGS. RESULTS:Compared with ACs, the NCGS, irrespective of modality of diagnosis, and patients with CD had significantly increased levels of zonulin, as did both NCGS and patients with CD compared with participants with IBS-D. Self-reported NCGS showed increased zonulin levels compared with double-blind confirmed and not-confirmed NCGS. Six-month wheat avoidance significantly reduced zonulin levels only in HLA-DQ2/8-positive participants with NCGS. The diagnostic accuracy of zonulin levels in distinguishing NCGS from IBS-D was 81%. After exclusion of CD, a diagnostic algorithm combining zonulin levels, symptoms and gender improved the accuracy to 89%. CONCLUSION:Zonulin can be considered a diagnostic biomarker in NCGS and combined with demographic and clinical data differentiates NCGS from IBS-D with high accuracy. Wheat withdrawal was associated with a reduction in zonulin levels only in NCGS carrying HLA genotype.
journal_name
Gutjournal_title
Gutauthors
Barbaro MR,Cremon C,Morselli-Labate AM,Di Sabatino A,Giuffrida P,Corazza GR,Di Stefano M,Caio G,Latella G,Ciacci C,Fuschi D,Mastroroberto M,Bellacosa L,Stanghellini V,Volta U,Barbara Gdoi
10.1136/gutjnl-2019-319281subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1966-1974issue
11eissn
0017-5749issn
1468-3288pii
gutjnl-2019-319281journal_volume
69pub_type
杂志文章相关文献
GUT文献大全abstract::To assess whether dietary antigens play a role in inflammatory bowel disease, 26 monozygotic twin pairs with inflammatory bowel disease and 52 healthy controls were investigated for serum antibodies (IgA, IgG, IgM) against ovalbumin, betalactoglobulin, gliadin, whole yeast (Saccharomyces cerevisiae) and yeast cell wal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.7.909
更新日期:1992-07-01 00:00:00
abstract::Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.1.101
更新日期:1985-01-01 00:00:00
abstract::Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.11.1539
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309638
更新日期:2016-02-01 00:00:00
abstract::Bran, ispaghula (Fybogel), and lactulose were given to three groups of patients with diverticular disease for four weeks. Faecal weights, bile acids, fat and electrolytes, transit time, and colonic motility were estimated before and after treatment. Stool weight increased, notably with Fybogel. Cereal bran had the gre...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.12.1144
更新日期:1978-12-01 00:00:00
abstract:OBJECTIVES:IBDs have an increased risk for development of colorectal cancer (CRC). Here, we aimed at the characterisation of the functional role of Th17-associated transcription factors in sporadic and colitis-associated colon cancer in vivo. DESIGN:We used mice deficient or transgenic for the activating protein 1 fam...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308227
更新日期:2016-07-01 00:00:00
abstract::Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.3.194
更新日期:1978-03-01 00:00:00
abstract::A 22 year old woman presenting with recurrent intestinal pseudo-obstruction is reported. Jejunal biopsy showed subtotal villous atrophy which improved markedly during a period of total parenteral nutrition and with steroid treatment. It did not relapse on a gluten free diet. The reasons why this patient represents a c...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.9.1003
更新日期:1984-09-01 00:00:00
abstract::The effects of low power (1-2 Watts), long exposure (30-400 seconds), interstitial Nd YAG laser therapy on dimethylhydrazine induced rat colonic neoplasms and normal rat colon have been studied. After a single exposure with appropriate laser parameters, dimethylhydrazine induced rat colonic neoplasms underwent coagula...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.1.27
更新日期:1988-01-01 00:00:00
abstract::Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.9.1107
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND AND AIMS:We investigated the influence of baseline characteristics of patients with hepatocellular carcinoma (HCC) on prognosis and developed a multivariate Cox model predicting survival. All patients were from Central Europe. METHODS:All 245 patients seen at the Department of Gastroenterology and Hepatolog...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.1.103
更新日期:2001-01-01 00:00:00
abstract::A method of in vivo calculation of liver volume using a gamma camera and a 1600 or 4096 channel analyser is described. Topographically, the maximum thickness giving the highest counts in matrix data in the right anterior oblique projection is measured as the maximum breadth in the right posterior oblique projection. T...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.17.4.289
更新日期:1976-04-01 00:00:00
abstract::The finding in primary IgA nephropathy of increased levels of IgA to food antigens and particularly to gliadin prompted the hypothesis that a subgroup of these patients may have latent coeliac disease. The observation that gliadin may experimentally induce IgA mesangial deposits supported this hypothesis. We evaluated...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.4.476
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.53.1.78
更新日期:2004-01-01 00:00:00
abstract::The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.34.6.843
更新日期:1993-06-01 00:00:00
abstract::These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319858
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311970
更新日期:2017-11-01 00:00:00
abstract::The effect of sodium taurocholate instillation on the stimulated stomachs of patients with duodenal ulceration has been investigated. Instillation into the stomach of sodium taurocholate significantly reduced pentagastrin stimulated volume and outputs of both acid and sodium, with no change in the calculated volume of...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.1.28
更新日期:1983-01-01 00:00:00
abstract::A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had ne...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.10.811
更新日期:1970-10-01 00:00:00
abstract::There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.4.531
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:The mechanisms underlying the suppression of somatostatin dependent reflexes in Helicobacter pylori infection are not fully determined. The H pylori product N alpha-methylhistamine and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) may be responsible for the alterations in somatostat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.176
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. This is illustrated by the non-neoplastic gastric-type heteroplasias present at birth in the pericaecal region of Cdx2(+/-) mice. Furthermore...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.10.1465
更新日期:2003-10-01 00:00:00
abstract::A study of HLA-DR antigen in 75 patients with primary biliary cirrhosis has been carried out in order to test the hypothesis that genetic factors related to genes controlling immune responses might be important in the pathogenesis of primary biliary cirrhosis. The frequencies of HLA-DR locus antigens was not significa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.6.625
更新日期:1985-06-01 00:00:00
abstract::An ileitis developing years or months after ileostomy was recognised and described many years ago but has rarely been mentioned since. We describe nine patients with a non-specific preanastomotic ileitis that developed years after colectomy in patients operated on for ulcerative colitis or carcinoma. The disease devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.373
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:A population based epidemiological study identified all the patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) resident in the Florence area in the period 1978-1992. AIMS:To assess the mortality of unselected patients with inflammatory bowel disease (IBD) in a Mediterranean country. ME...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.2.175
更新日期:1998-02-01 00:00:00
abstract::Six New Zealand white rabbits were given gas induction anaesthetics and maintained on glucochloralose (Merck) 60 mg/kg given intravenously. Intracolonic pressures were measured after a standard dose of prostigmine, 0.05 mg/kg, using fluid-filled, open-tipped, narrow-bore polythene tubes. Then the rabbits were put on a...
journal_title:Gut
pub_type: 杂志文章
doi:
更新日期:1972-10-01 00:00:00
abstract:BACKGROUND:Hereditary pancreatitis (HP) is a rare autosomal dominant disorder with variable expression and an overall lifetime penetrance of 80%. We hypothesised that (1) monozygotic twins within similar environments would develop the typical signs of HP at a similar age, and (2) if penetrance were due to modifier gene...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.4.542
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-305281
更新日期:2014-10-01 00:00:00
abstract::In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without ev...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.10.814
更新日期:1982-10-01 00:00:00
abstract::To determine whether primary biliary cirrhosis differed in men and women we reviewed the presenting features and clinical course of 39 men and 191 women with primary biliary cirrhosis followed at this unit between 1970 and 1984. Age and severity of disease at time of diagnosis were similar in both groups. Pruritus was...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.11.1373
更新日期:1986-11-01 00:00:00