Abstract:
:Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchanged compared with sham operated rats. Intragastric instillation of fat increased the plasma concentration of NTLI from 45 pmol/l (34-63) in sham operated rats to 92 pmol/l (46-121) in resected rats. No significant increase in the plasma concentration of NTLI was found after intragastric instillation of amino acids or glucose. The tissue concentration of NTLI increased significantly in the jejunum and ileum after proximal small intestinal resection, while the number of immunoreactive neurotensin cells was unchanged. This study shows that the adaptive responses in the distal small intestine after proximal small intestinal resection also involve the neurotensin producing cells.
journal_name
Gutjournal_title
Gutauthors
Olsen PS,Pedersen JH,Poulsen SS,Yamashita Y,Kirkegaard Pdoi
10.1136/gut.28.9.1107subject
Has Abstractpub_date
1987-09-01 00:00:00pages
1107-11issue
9eissn
0017-5749issn
1468-3288journal_volume
28pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308163
更新日期:2015-03-01 00:00:00
abstract::The effects of pentagastrin and the putative gastrin antagonist proglumide on interdigestive motility of the upper small bowel were studied in a randomised double blind study in 10 healthy human volunteers. Intraluminal pressures were recorded manometrically in the duodenum and jejunum for five hours. Sixty minutes af...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.9.953
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066100
更新日期:2006-02-01 00:00:00
abstract::We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.207
更新日期:1987-01-01 00:00:00
abstract::It has been proposed that anti-inflammatory actions of corticosteroids rely on promotion of a natural peptide phospholipase A2 inhibitor, lipocortin, but in vivo effects on arachidonic acid metabolism have not been shown. Equilibrium dialysis of the rectum in patients with ulcerative colitis was used to determine whet...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.9.1095
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:The indications for intestinal transplantation (ITx) are still debated. Knowing survival rates and causes of death on home parenteral nutrition (HPN) will improve decisions. METHODS:A prospective 5-year study compared 389 non-candidates (no indication, no contraindication) and 156 candidates (indication, no...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2010.223255
更新日期:2011-01-01 00:00:00
abstract::When there is villus atrophy in a jejunal biopsy, intraepithelial lymphocyte (IEL) mitosis correlates with a diagnosis of coeliac disease. We have examined the significance of IEL mitosis in jejunal biopsies with normal villi. Counts of IEL per 100 villus enterocytes, and IEL mitosis per 1000 IEL, were carried out in ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.6.675
更新日期:1986-06-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract::Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical poin...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.51.suppl_1.i67
更新日期:2002-07-01 00:00:00
abstract::Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury. ...
journal_title:Gut
pub_type: 评论,杂志文章,评审
doi:10.1136/gut.2004.060640
更新日期:2005-07-01 00:00:00
abstract::The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.8.934
更新日期:1990-08-01 00:00:00
abstract::The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s36
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated c...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310255
更新日期:2017-05-01 00:00:00
abstract::We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.4.326
更新日期:1982-04-01 00:00:00
abstract::The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.9.703
更新日期:1977-09-01 00:00:00
abstract::Coeliac disease is triggered by ingestion of wheat gliadin and is probably immune mediated. There is evidence by light microscopy that expression of class II major histocompatibility complex (MHC) molecules is increased in the small intestinal epithelium of patients with untreated coeliac disease and that gliadin can ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.703
更新日期:1995-05-01 00:00:00
abstract::The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.2.171
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:"Probiotic" bacteria are effective in treating some inflammatory bowel diseases. However which bacteria confer benefit and mechanisms of action remain poorly defined. Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in med...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.037325
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Almost 4% of the population suffer from food allergy which is an adverse reaction to food with an underlying immunological mechanism. AIMS:To characterise one of the most frequent IgE defined food allergens, fish parvalbumin. METHODS:Tissue and subcellular distribution of carp parvalbumin was analysed by i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.5.661
更新日期:2000-05-01 00:00:00
abstract::Although a high prevalence of antibodies to Helicobacter pylori has been documented within families, culture and DNA typing of strains from infected children and their parents has not been evaluated. This study aimed to analyse H pylori infection within family groups. Endoscopy, gastric biopsy, and H pylori culture we...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.10.1348
更新日期:1993-10-01 00:00:00
abstract::Video endoscopic images were used to investigate whether gastroenterologists could agree on the definition of lesions within the stomach seen at endoscopy, with particular reference to those seen in patients taking non-steroidal anti-inflammatory drugs. Seven experienced endoscopists, unaware of the patients' clinical...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.8.1030
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Meal ingestion is often associated with exacerbation of gastrointestinal symptoms in subjects with irritable bowel syndrome (IBS). Furthermore, recent preliminary data suggest that 5-hydroxytryptamine (5-HT) concentration in platelet poor plasma is elevated following meal ingestion in some subjects with diar...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.5.663
更新日期:2003-05-01 00:00:00
abstract::The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfa...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.2.206
更新日期:1984-02-01 00:00:00
abstract::Little is known about chronic constipation in infants, toddlers, and preschool children and longterm outcome after treatment. The symptoms of 174 children < or = 4 years of age, who were evaluated for chronic constipation, are reported in this study together with the long-term outcome in 90 of them. Initial symptoms w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.10.1400
更新日期:1993-10-01 00:00:00
abstract::To investigate the basis of subclinical alveolitis in patients with primary biliary cirrhosis, 10 primary biliary cirrhosis patients were studied by bronchoalveolar lavage. Both bronchoalveolar lavage lymphoid and non-lymphoid cell populations were analysed using immunocytological methods to determine their proportion...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.2.208
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The risk of colorectal cancer is increased in ulcerative colitis (UC). Patients with UC have diverse colonoscopic appearances. Determining colonoscopic markers for cancer risk could allow patient risk stratification. PATIENTS AND METHODS:Following on from an earlier study which demonstrated a corre...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.038505
更新日期:2004-12-01 00:00:00
abstract::Because previous studies have suggested that red cell membrane sialic acid might be a determinant of survival in vivo, we examined the relationship between haemolysis, erythrocyte membrane sialic acid, and hepatic neuraminidase (sialidase) levels in experimental cholestatic jaundice in rats. Treatment of normal rat er...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.10.794
更新日期:1974-10-01 00:00:00
abstract::An epidemiological survey of Crohn's disease in the city of Derby showed that the incidence of the condition increased from 0.7/10(5) per year between 1951 and 1955 to 6.67/10(5) per year between 1981 and 1985 but seemed to reach a plateau between 1976 and 1985. Large bowel Crohn's disease was more common in patients ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.11.1262
更新日期:1990-11-01 00:00:00
abstract::Pouchitis may complicate the construction of an ileal pouch after colectomy for ulcerative colitis (UC) but not familial adenomatous polyposis (FAP). To examine whether differences in eicosanoid metabolism might explain why pouchitis is largely confined to UC patients, this study compared arachidonic acid stimulated r...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.10.1429
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:The incidence figures for ulcerative colitis (UC) and Crohn's disease (CD) have been difficult to interpret, and geographical variations may be due to differences in classification criteria and study design. Few studies have based the incidence on prospective systematic follow up to confirm the initial diagn...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.3.328
更新日期:1997-03-01 00:00:00