Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome.

abstract：:Macrophage major histocompatibility complex (MHC) class II antigen expression is associated with defective antigen presentation to T lymphocytes in animals and is predictive of patient outcome after major trauma or sepsis. In this study, class II antigen (HLA-DR and DQ) expression on peripheral blood monocytes was inv...

journal_title：Gut

authors： Gardiner KR,Crockard AD,Halliday MI,Rowlands BJ

更新日期：1994-04-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：:To evaluate the effects of cisapride on gastric emptying of extracellular fat and hunger and fullness 10 volunteers consumed a meal consisting of 60 ml technectium-99m (99mTc)-V-thiocyanate labelled olive oil and 290 ml indium-113m (113mIn) labelled soup after taking cisapride (10 mg four times daily orally) and place...

journal_title：Gut

authors： Jones KL,Horowitz M,Carney BI,Sun WM,Chatterton BE

更新日期：1996-03-01 00:00:00

abstract：:The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...

journal_title：Gut

authors： Camilleri M

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer is the second most common cause of cancer death in Europe and North America. Alarm features are used to prioritize access to urgent investigation, but there is little information concerning their utility in the diagnosis of colorectal cancer. METHODS:A systematic review and meta-analysis of...

journal_title：Gut

authors： Ford AC,Veldhuyzen van Zanten SJ,Rodgers CC,Talley NJ,Vakil NB,Moayyedi P

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumours and cell lines. Based on this evidence, it was presumed that GKN1 might play a role in gastric cancer development; however, its function and molecular mechanism are not clear. A ...

journal_title：Gut

authors： Xing R,Li W,Cui J,Zhang J,Kang B,Wang Y,Wang Z,Liu S,Lu Y

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...

journal_title：Gut

authors： Hézode C,Hirschfield GM,Ghesquiere W,Sievert W,Rodriguez-Torres M,Shafran SD,Thuluvath PJ,Tatum HA,Waked I,Esmat G,Lawitz EJ,Rustgi VK,Pol S,Weis N,Pockros PJ,Bourlière M,Serfaty L,Vierling JM,Fried MW,Weiland O,B

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, a significant inverse correlation between postparacentesis changes in plasma renin activity and systemic vascular resistance has been d...

journal_title：Gut

authors： Cabrera J,Falcón L,Gorriz E,Pardo MD,Granados R,Quinones A,Maynar M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN:International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structu...

journal_title：Gut

authors： Scott AJ,Alexander JL,Merrifield CA,Cunningham D,Jobin C,Brown R,Alverdy J,O'Keefe SJ,Gaskins HR,Teare J,Yu J,Hughes DJ,Verstraelen H,Burton J,O'Toole PW,Rosenberg DW,Marchesi JR,Kinross JM

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control fro...

journal_title：Gut

authors： Bodger K,Ormerod C,Shackcloth D,Harrison M,IBD Control Collaborative.

更新日期：2014-07-01 00:00:00

abstract：:To determine the optimum dose of ispaghula husk in patients with irritable bowel syndrome (IBS) and to assess the correlation, if any between the relief in patients' symptoms and the whole gut transit time, and the increase in stool weight, a two part study was carried out. In part 1, 14 male patients were given ispag...

journal_title：Gut

authors： Kumar A,Kumar N,Vij JC,Sarin SK,Anand BS

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:A rapid, reliable, and accurate test for the diagnosis of infection with Helicobacter pylori is needed for screening dyspeptic patients before referral for endoscopy. AIM:To compare a new rapid whole blood test (Helisal rapid blood, Cortecs), two serum enzyme linked immunosorbent assays (ELISAs; Helico-G, S...

journal_title：Gut

authors： Reilly TG,Poxon V,Sanders DS,Elliott TS,Walt RP

更新日期：1997-04-01 00:00:00

abstract：:The prevalence of metabolic disease in a population of 68 postgastrectomy patients was assessed using histomorphometric evaluation of transiliac bone biopsy specimens after tetracycline double labelling. Trabecular bone volume was significantly lower in the postgastrectomy group (p less than 0.01): 62% of the patients...

journal_title：Gut

authors： Bisballe S,Eriksen EF,Melsen F,Mosekilde L,Sørensen OH,Hessov I

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Genetic haemochromatosis is a common hereditary iron loading disorder in humans. The disease is associated with loss of function mutations in the HFE gene. This is thought to change iron stores via increased iron absorption. AIMS:In this study we investigated how adaptation of mucosal reductase activity is ...

journal_title：Gut

authors： Simpson RJ,Debnam E,Beaumont N,Bahram S,Schümann K,Srai SK

更新日期：2003-04-01 00:00:00

abstract：:To study the mechanism for the adaptive mucosal hyperplasia which occurs independent of luminal nutrition and pancreatico-biliary secretions in isolated Thiry-Vella segments of intestine from lactating rats, and to examine the effects of prolactin on small bowel mucosal structure in the rat, we used two models of expe...

journal_title：Gut

authors： Muller E,Dowling RH

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...

journal_title：Gut

authors： Kiesslich R,Duckworth CA,Moussata D,Gloeckner A,Lim LG,Goetz M,Pritchard DM,Galle PR,Neurath MF,Watson AJ

更新日期：2012-08-01 00:00:00

abstract：:Introduction of a radioactive gastrointestinal marker (51CrCl3) into a combined study (75SeHCAT + 58CoB12) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid ar...

journal_title：Gut

authors： Smith T,Bjarnason I

更新日期：1990-10-01 00:00:00

abstract：:In a randomised clinical trial, patients with moderately active Crohn's disease received either prednisolone 0.5 mg/kg/day plus a normal diet, or an elemental diet plus oral framycetin, colistin and nystatin. Patients were assessed using the Crohn's disease activity index (CDAI), ESR, and faecal granulocyte excretion ...

journal_title：Gut

authors： Saverymuttu S,Hodgson HJ,Chadwick VS

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....

journal_title：Gut

authors： Troeger H,Loddenkemper C,Schneider T,Schreier E,Epple HJ,Zeitz M,Fromm M,Schulzke JD

更新日期：2009-08-01 00:00:00

abstract：:Increased antibody production and hypergammaglobulinaemia in cirrhosis are probably to a large extent due to decreased hepatic extraction of antigens. The deceased extraction is presumably related to changed microcirculation caused by damaged anatomical structure of the liver. It is therefore to be expected that immun...

journal_title：Gut

authors： Prytz H,Bjorneboe M,Christoffersen P,Poulsen H,Orskov F

更新日期：1977-01-01 00:00:00

abstract：:Increased concentrations of the soluble form of the interleukin 2 receptor have been observed in the sera of Crohn's disease and ulcerative colitis patients. In this study we have observed the spontaneous release of soluble interleukin 2 receptor by unstimulated, isolated normal and inflammatory bowel disease colonic ...

journal_title：Gut

authors： Schreiber S,Raedler A,Conn AR,Rombeau JL,MacDermott RP

更新日期：1992-02-01 00:00:00

abstract：:Family histories were obtained from 50 patients with adenocarcinoma of the colon or rectum in north-east Scotland. A comparable control group was similarly interviewed and in each group the case notes of the first degree relatives were studied where possible. Eight (16%) of the patients with cancer of the colon or rec...

journal_title：Gut

authors： Duncan JL,Kyle J

更新日期：1982-02-01 00:00:00

abstract：:Colonic biopsy specimens were obtained from patients undergoing surgery for carcinoma of the rectum. Colonic resistance arteries (internal diameter 178-345 microns) were dissected out under the microscope and mounted in a microvascular myograph capable of measuring isometric tension development. Experiments were desig...

journal_title：Gut

authors： Mortensen FV,Nielsen H,Mulvany MJ,Hessov I

更新日期：1990-12-01 00:00:00

abstract：:Alcohol tolerance has been studied in 10 patients after proximal gastric vagotomy and six patients after truncal vagotomy and antrectomy. No difference in alcohol tolerance was found before and after proximal gastric vagotomy, while an increased rate of absorption with higher blood levels of alcohol were found after t...

journal_title：Gut

authors： Moodie AF,Royston CM,Spencer J

更新日期：1975-12-01 00:00:00

abstract：OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....

journal_title：Gut

authors： Nieuwenburg SAV,Vuik FER,Kruip MJHA,Kuipers EJ,Spaander MCW

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this ...

journal_title：Gut

authors： Farges O,Ferreira N,Dokmak S,Belghiti J,Bedossa P,Paradis V

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Linkage data have now identified several inflammatory bowel disease (IBD) susceptibility loci but these data have not been consistently replicated in independent studies. One potential explanation for this is the possibility that patients enrolled in such studies may have been erroneously classified with res...

journal_title：Gut

authors： Silverberg MS,Daly MJ,Moskovitz DN,Rioux JD,McLeod RS,Cohen Z,Greenberg GR,Hudson TJ,Siminovitch KA,Steinhart AH

更新日期：2001-12-01 00:00:00

abstract：:A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...

journal_title：Gut

authors： Ludvigsson JF,Bai JC,Biagi F,Card TR,Ciacci C,Ciclitira PJ,Green PH,Hadjivassiliou M,Holdoway A,van Heel DA,Kaukinen K,Leffler DA,Leonard JN,Lundin KE,McGough N,Davidson M,Murray JA,Swift GL,Walker MM,Zingone F,Sa

更新日期：2014-08-01 00:00:00

abstract：:Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception-that is, its relation to clinical symptoms-remains unclear. Data indicate that sensory dysfunction is associated with altered re...

journal_title：Gut

authors： Azpiroz F

更新日期：2002-07-01 00:00:00

abstract：:Fifteen patients with severe intractable irritable bowel syndrome previously reported as successfully treated with hypnotherapy, have now been followed up for a mean duration of 18 months. All patients remain in remission although two have experienced a single relapse overcome by an additional session of hypnotherapy....

journal_title：Gut

authors： Whorwell PJ,Prior A,Colgan SM

更新日期：1987-04-01 00:00:00