Family incidence of carcinoma of the colon and rectum in north-east Scotland.

abstract：:Glucosamine synthetase, the first enzyme in glycoprotein synthesis, has been measured in serial rectal biopsies in four patients with membranous colitis. In two of the patients the levels of the enzyme were very high initially and in the other two patients the enzyme levels rose to a peak above the normal range after ...

journal_title：Gut

authors： Goodman MJ,Kent PW,Truelove SC

更新日期：1977-03-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...

journal_title：Gut

authors： Bedossa P,Tordjman J,Aron-Wisnewsky J,Poitou C,Oppert JM,Torcivia A,Bouillot JL,Paradis V,Ratziu V,Clément K

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The incidence figures for ulcerative colitis (UC) and Crohn's disease (CD) have been difficult to interpret, and geographical variations may be due to differences in classification criteria and study design. Few studies have based the incidence on prospective systematic follow up to confirm the initial diagn...

journal_title：Gut

authors： Moum B,Ekbom A,Vatn MH,Aadland E,Sauar J,Lygren I,Schulz T,Stray N,Fausa O

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVES:Novel imaging methods based on specific molecular targets to detect both established neoplasms and their precursor lesions are highly desirable in cancer medicine. Previously, we identified claudin-4, an integral constituent of tight junctions, as highly expressed in various gastrointestinal tumours includin...

journal_title：Gut

authors： Neesse A,Hahnenkamp A,Griesmann H,Buchholz M,Hahn SA,Maghnouj A,Fendrich V,Ring J,Sipos B,Tuveson DA,Bremer C,Gress TM,Michl P

更新日期：2013-07-01 00:00:00

abstract：:Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were r...

journal_title：Gut

authors： Schröder H,Evans DA

更新日期：1972-04-01 00:00:00

abstract：:Patients with Crohn's disease commonly develop ileal and less commonly colonic strictures, containing various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment, predominantly fibrotic strictures currently require endoscopic balloon ...

journal_title：Gut

authors： Bettenworth D,Bokemeyer A,Baker M,Mao R,Parker CE,Nguyen T,Ma C,Panés J,Rimola J,Fletcher JG,Jairath V,Feagan BG,Rieder F,Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium.

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectal neoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia....

journal_title：Gut

authors： Fujii S,Tominaga K,Kitajima K,Takeda J,Kusaka T,Fujita M,Ichikawa K,Tomita S,Ohkura Y,Ono Y,Imura J,Chiba T,Fujimori T

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Interstitial cells of Cajal (ICC) are pacemakers and mediators of motor neurotransmission in gastrointestinal smooth muscles. ICC require cellular signalling via Kit, a receptor tyrosine kinase, for development and maintenance of phenotype. Much of the evidence demonstrating the functions of ICC com...

journal_title：Gut

authors： Takayama I,Daigo Y,Ward SM,Sanders KM,Walker RL,Horowitz B,Yamanaka T,Fujino MA

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Patients with chronic hepatitis B (CHB) infection are at an increased risk of developing hepatocellular carcinoma (HCC). Risk scores have been developed in Asian populations to predict HCC risk over time. AIM:To assess the performance of HCC risk prediction models in a heterogeneous population of patients w...

journal_title：Gut

authors： Abu-Amara M,Cerocchi O,Malhi G,Sharma S,Yim C,Shah H,Wong DK,Janssen HL,Feld JJ

更新日期：2016-08-01 00:00:00

abstract：:Two peptides which are potent stimulants of gastric acid secretion are isolated from Zollinger-Ellison tumour tissue. They have aminoacid constitutions identical with those of human gastrin types I and II as isolated from human antral mucosa, and they are present in similar proportions. Their electrophoretic and chrom...

journal_title：Gut

authors： Gregory RA,Tracy HJ,Agarwal KL,Grossman MI

更新日期：1969-08-01 00:00:00

abstract：:Big differences in the prevalence of peptic ulcer are known to exist in different parts of India. This paper reports a high incidence in Assam and records certain differences with peptic ulcers found in south India. ...

journal_title：Gut

authors： MALHOTRA SL,MAJUMDAR CT,BARDOLOI PC

更新日期：1964-08-01 00:00:00

abstract：BACKGROUND:Caroli's disease is a rare congenital disorder characterised by cystic dilatation of the intrahepatic bile ducts and an increased risk of cholangiocellular carcinoma. The cause is unknown, but occasional familial clustering suggests that some cases are inherited, in particular when occurring in association w...

journal_title：Gut

authors： Parada LA,Hallén M,Hägerstrand I,Tranberg KG,Johansson B

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...

journal_title：Gut

authors： Drewes AM,Sami SA,Dimcevski G,Nielsen KD,Funch-Jensen P,Valeriani M,Arendt-Nielsen L

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...

journal_title：Gut

authors： Camilleri M

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Previous studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families. PATIENTS AND METHODS:A total of 1223 individuals at risk from 106 families (264 affected individuals) w...

journal_title：Gut

authors： McFaul CD,Greenhalf W,Earl J,Howes N,Neoptolemos JP,Kress R,Sina-Frey M,Rieder H,Hahn S,Bartsch DK,European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC).,German National Case Collection for Familial

更新日期：2006-02-01 00:00:00

abstract：:The leakiness of the cell membranes of colonic epithelial cells isolated by the collagenase/Dispase technique from normal or diseased colons was assessed in a 4 h 51Cr release assay. Cells from normal, adenoma bearing or cancer bearing colons showed 51Cr release of 8% or less in almost all of 46 cell populations teste...

journal_title：Gut

authors： Gibson PR,van de Pol E,Barratt PJ,Doe WF

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Several cases of acute colitis induced by non-steroidal anti-inflammatory drugs (NSAIDs) have been reported but the general role of recent NSAID intake as a risk factor for acute diarrhoea has not been studied to date. The aim of our study was to determine whether the risk of acute diarrhoea is incr...

journal_title：Gut

authors： Etienney I,Beaugerie L,Viboud C,Flahault A

更新日期：2003-02-01 00:00:00

abstract：:Spirits from areas of high and low incidence of cancer of the oesophagus were examined for volatile nitrosamines using a chemiluminescent detector. No nitrosamines were found, the detection limit being 0.001 microng/ml. ...

journal_title：Gut

authors： Gough TA

更新日期：1977-04-01 00:00:00

abstract：INTRODUCTION:Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC). METHODS:The ICBP SURVMARK-2 project...

journal_title：Gut

authors： Morgan E,Soerjomataram I,Gavin AT,Rutherford MJ,Gatenby P,Bardot A,Ferlay J,Bucher O,De P,Engholm G,Jackson C,Kozie S,Little A,Møller B,Shack L,Tervonen H,Thursfield V,Vernon S,Walsh PM,Woods RR,Finley C,Merrett

更新日期：2021-02-01 00:00:00

abstract：:Thirty male patients (27 homosexual) with biopsy proven chronic active hepatitis B were randomised to receive lymphoblastoid interferon (Wellferon) or no treatment. All patients were HBeAg positive and had continuing viral replication. Patients receiving treatment were given a single daily intramuscular injection of i...

journal_title：Gut

authors： Anderson MG,Harrison TJ,Alexander G,Zuckerman AJ,Murray-Lyon IM

更新日期：1987-05-01 00:00:00

abstract：:The thoracic duct was cannulated in six patients who were actively bleeding from varices and had not responded to conservative treatment but draining lymph from the thoracic duct did not control bleeding in five patients. There was no drop in intrasplenic pulp pressure following this procedure when recorded in three o...

journal_title：Gut

authors： Datta DV,Singh SA,Patra BS,Saini VK,Chhuttani PN

更新日期：1971-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...

journal_title：Gut

authors： Houghton LA,Calvert EL,Jackson NA,Cooper P,Whorwell PJ

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：:Lactulose H2 breath tests are widely used for quantifying carbohydrate malabsorption, but the validity of the commonly used technique (interval sampling of H2 concentrations) has not been systematically investigated. In eight healthy adults we studied the reproducibility of the technique and the accuracy with which 5 ...

journal_title：Gut

authors： Rumessen JJ,Hamberg O,Gudmand-Høyer E

更新日期：1990-01-01 00:00:00

abstract：:The extent to which monitoring breath hydrogen excretion provides information concerning the entry of the residues of a solid test meal into the colon was investigated in 89 normal subjects, and 11 patients with the irritable bowel syndrome. The profile of breath hydrogen concentration showed an early peak, that occur...

journal_title：Gut

authors： Read NW,Al-Janabi MN,Bates TE,Holgate AM,Cann PA,Kinsman RI,McFarlane A,Brown C

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Micrometastases within bone marrow have been shown to indicate a poor prognosis in patients with epithelial tumours. However, the degree to which micrometastases represent true residual disease or cell shedding and metastatic potential, is unclear. AIM:To explore whether micrometastases represent residual d...

journal_title：Gut

authors： O'Sullivan GC,Collins JK,Kelly J,Morgan J,Madden M,Shanahan F

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...

journal_title：Gut

authors： Picton R,Eggo MC,Merrill GA,Langman MJ,Singh S

更新日期：2002-02-01 00:00:00

abstract：:Eight patients with diffuse plasma cell infiltration of the small bowel who had the clinical features of immunoproliferative small intestinal disease (IPSID), but whose serum was negative for free alpha-heavy chains, were investigated for evidence of a non-secretory form of alpha-chain disease (alpha-CD). Molecular si...

journal_title：Gut

authors： Gilinsky NH,Mee AS,Beatty DW,Novis BH,Young G,Price S,Purves LR,Marks IN

更新日期：1985-09-01 00:00:00

abstract：:Colorectal cancer is the second commonest cause of cancer death in the UK. An effective national screening programme is urgently required to reduce the substantial morbidity and mortality from the disease. The success of any screening programme will depend on the screening test detecting early Dukes's A carcinomas and...

journal_title：Gut

authors： Hart AR,Wicks AC,Mayberry JF

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...

journal_title：Gut

authors： Lafontaine DA,Mercure S,Perreault JP

更新日期：1998-06-01 00:00:00