The applicability of hepatocellular carcinoma risk prediction scores in a North American patient population with chronic hepatitis B infection.

Abstract:

BACKGROUND:Patients with chronic hepatitis B (CHB) infection are at an increased risk of developing hepatocellular carcinoma (HCC). Risk scores have been developed in Asian populations to predict HCC risk over time. AIM:To assess the performance of HCC risk prediction models in a heterogeneous population of patients with CHB. METHODS:Scores were calculated at baseline using CU-HCC, REACH-B, NGM1-HCC, NGM2-HCC and GAG-HCC models and the incidence of HCC was determined. The predictive ability of each score was evaluated using the area under the receiver operating characteristic curve (AUROC), Cox regression and plots of observed versus predicted HCC. The predictive value of the scores was compared between Asian and non-Asian patients and between cirrhotic versus non-cirrhotic with and without treatment. RESULTS:Of 2105 patients, 70 developed HCC. Increasing risk score was associated with HCC in all models. The CU-HCC model had the highest AUROC in Asian (0.85) and non-Asian (0.91) patients. Patients identified as low risk by any model had a very low incidence of HCC (0-0.15 per year), with the highest proportion of patients identified as low risk using CU-HCC (67%) or GAG-HCC (78%). The risk of HCC was similar to predicted for low-risk and medium-risk patients but was lower than predicted for high-risk patients. Treated patients had a lower than predicted risk of HCC, particularly in non-cirrhotic high-risk patients with longer follow-up. CONCLUSIONS:Although all models predicted the risk of HCC, models that incorporated parameters of liver function or cirrhosis (CU-HCC/GAG-HCC) were most accurate. Low-risk patients likely require reduced HCC surveillance.

journal_name

Gut

journal_title

Gut

authors

Abu-Amara M,Cerocchi O,Malhi G,Sharma S,Yim C,Shah H,Wong DK,Janssen HL,Feld JJ

doi

10.1136/gutjnl-2014-309099

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1347-58

issue

8

eissn

0017-5749

issn

1468-3288

pii

gutjnl-2014-309099

journal_volume

65

pub_type

杂志文章

相关文献

GUT文献大全
  • Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.

    abstract::Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.19.3.194

    authors: Vison N,Hecketsweiler P,Butel J,Bernier JJ

    更新日期:1978-03-01 00:00:00

  • MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-300717

    authors: Ogawa T,Enomoto M,Fujii H,Sekiya Y,Yoshizato K,Ikeda K,Kawada N

    更新日期:2012-11-01 00:00:00

  • Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study.

    abstract:OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321411

    authors: Bezzio C,Saibeni S,Variola A,Allocca M,Massari A,Gerardi V,Casini V,Ricci C,Zingone F,Amato A,Caprioli F,Lenti MV,Viganò C,Ascolani M,Bossa F,Castiglione F,Cortelezzi C,Grossi L,Milla M,Morganti D,Pastorelli L,R

    更新日期:2020-07-01 00:00:00

  • Prognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 years.

    abstract:BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究

    doi:10.1136/gut.2006.109157

    authors: Konishi T,Watanabe T,Kishimoto J,Kotake K,Muto T,Nagawa H,Japanese Society for Cancer of the Colon and Rectum.

    更新日期:2007-06-01 00:00:00

  • Prebiotic inulin-type fructans induce specific changes in the human gut microbiota.

    abstract:OBJECTIVE:Contrary to the long-standing prerequisite of inducing selective (ie, bifidogenic) effects, recent findings suggest that prebiotic interventions lead to ecosystem-wide microbiota shifts. Yet, a comprehensive characterisation of this process is still lacking. Here, we apply 16S rDNA microbiota profiling and ma...

    journal_title:Gut

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/gutjnl-2016-313271

    authors: Vandeputte D,Falony G,Vieira-Silva S,Wang J,Sailer M,Theis S,Verbeke K,Raes J

    更新日期:2017-11-01 00:00:00

  • Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial.

    abstract:BACKGROUND:Pyoderma gangrenosum (PG) is a chronic ulcerating skin condition that often occurs in association with inflammatory bowel disease. There have been a number of reports of PG responding to infliximab, a monoclonal antibody against tumour necrosis factor alpha. AIM:In the first randomised placebo controlled tr...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2005.074815

    authors: Brooklyn TN,Dunnill MG,Shetty A,Bowden JJ,Williams JD,Griffiths CE,Forbes A,Greenwood R,Probert CS

    更新日期:2006-04-01 00:00:00

  • Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma.

    abstract::Recent evidence suggests that the production of colorectal carcinogens is facilitated when the pH of the colonic contents is alkaline. It follows that the colonic intraluminal pH of patients with colorectal neoplasms should be higher than in normal subjects. Gastrointestinal pH has been measured in 30 patients with co...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.12.1355

    authors: Pye G,Evans DF,Ledingham S,Hardcastle JD

    更新日期:1990-12-01 00:00:00

  • Benign lymphangioma of the jejunal mesentery: an unusual cause of small bowel obstruction.

    abstract::Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.12.1568

    authors: Campbell WJ,Irwin ST,Biggart JD

    更新日期:1991-12-01 00:00:00

  • Reversible effect of phytohaemagglutinin on the growth and metabolism of rat gastrointestinal tract.

    abstract::The lectin, phytohaemagglutinin, present in beans survives passage through the gastrointestinal tract in a biologically and immunologically intact form. It is known that by binding to the brush border membranes of the small intestine phytohaemagglutinin induces its hyperplastic growth. However, its effect on the other...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.3.353

    authors: Bardocz S,Grant G,Ewen SW,Duguid TJ,Brown DS,Englyst K,Pusztai A

    更新日期:1995-09-01 00:00:00

  • Evaluation of indium scintigraphy in patients with active inflammatory bowel disease.

    abstract::Recent reports have indicated a possible role for 111Indium leucocyte scintigraphy in the management of patients with acute inflammatory bowel disease. Our experience with this technique in 15 patients (nine with ulcerative colitis, six with Crohn's disease) is described. Perfect agreement was not obtained between sci...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.12.1372

    authors: Buxton-Thomas MS,Dickinson RJ,Maltby P,Hunter JO,Wraight EP

    更新日期:1984-12-01 00:00:00

  • Refractory pouchitis: does it reflect underlying Crohn's disease?

    abstract::Typical 'pouchitis' is a well recognised complication of ileal pouches in ulcerative colitis. Infrequently, a refractory pouchitis (RP) presents with certain clinical, endoscopic, and pathological features resembling Crohn's disease and is often ascribed to misdiagnosis of the initial colitis. To test that hypothesis ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.11.1539

    authors: Subramani K,Harpaz N,Bilotta J,Bodian C,Rubin PH,Janowitz HD,Gelernt IM,Sachar DB

    更新日期:1993-11-01 00:00:00

  • Effect of dietary nucleotides on small intestinal repair after diarrhoea. Histological and ultrastructural changes.

    abstract::The effects of specific nutrients on intestinal maturation and repair after injury are practically unknown. The purpose of this work was to study the effects of dietary nucleotides on the repair of the intestinal mucosa after chronic diarrhoea induced by a lactose enriched diet in the weanling rat. One group of weanli...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.7.926

    authors: Bueno J,Torres M,Almendros A,Carmona R,Nuñez MC,Rios A,Gil A

    更新日期:1994-07-01 00:00:00

  • Inhibitory effect of unconjugated bile acids on the intestinal transport of 5-methyltetrahydrofolate in rat jejunum in vitro.

    abstract::The effect of the unconjugated bile acids, cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids, and of the conjugated bile acid taurocholic acid on the mucosal-to-serosal transport and tissue uptake of the naturally occurring folate derivative, 5-methyltetrahydrofolate (5-CH3H4PteGlu) was examined in ever...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.12.1376

    authors: Said HM,Hollander D,Strum WB

    更新日期:1984-12-01 00:00:00

  • Faecal alpha-1-antitrypsin and excretion of 111indium granulocytes in assessment of disease activity in chronic inflammatory bowel diseases.

    abstract::Intestinal protein loss in chronic inflammatory bowel diseases may be easily determined by measurement of alpha-1-antitrypsin (alpha 1-AT) stool concentration and alpha 1-AT clearance. Both parameters were significantly raised in 36 and 34 patients respectively with chronic inflammatory bowel diseases, compared with e...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.4.386

    authors: Fischbach W,Becker W,Mössner J,Koch W,Reiners C

    更新日期:1987-04-01 00:00:00

  • Chloride dependent amino acid transport in the human small intestine.

    abstract::Carriers of beta amino acids and imino acids in the small intestine of rabbits and guinea pigs are chloride dependent, and a cotransport of chloride, sodium, and 2-methyl-aminoisobutyric acid has been shown. This study examines the chloride dependence of amino acid transport in the human small intestine. The steady st...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.36.2.215

    authors: Munck LK

    更新日期:1995-02-01 00:00:00

  • Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease.

    abstract:BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.39.3.374

    authors: Bjarnason I,Batt R,Catt S,Macpherson A,Maxton D,Menzies IS

    更新日期:1996-09-01 00:00:00

  • Timing of ileocolonic resection for symptomatic Crohn's disease--the patient's view.

    abstract::Eighty patients were asked if they would have preferred their ileocolonic resection and anastomosis for Crohn's disease, to have been carried out sooner, later or at the same time as it was done. Seventy of the patients replied (88%). No patient would have preferred their operation to have been later, while 74% though...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.5.656

    authors: Scott NA,Hughes LE

    更新日期:1994-05-01 00:00:00

  • The effects of different bile salts on the absorption of fluid, electrolytes, and monosaccharides in the small intestine of the rat in vivo.

    abstract::The effects of different bile salts on the absorption of fluid, electrolytes, and monosaccharides have been investigated in the rat small intestine in vivo. In the jejunum, deoxycholate (1 mM) impaired absorption of water and potassium, but not of sodium or glucose; at higher concentrations (2.5 and 5 mM) secretion of...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.13.8.596

    authors: Harries JT,Sladen GE

    更新日期:1972-08-01 00:00:00

  • Production of antibodies to gliadin in intestinal mucosa of patients with coeliac disease: a study at the single cell level.

    abstract::Lymphocytes obtained after enzymatic digestion of intestinal biopsies from patients with coeliac disease were examined for the presence of gliadin specific antibody secreting cells by means of the ELISPOT technique. This technique permits enumeration of gliadin antibody secreting immunocytes, differentiated with regar...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.30.1.72

    authors: Lycke N,Kilander A,Nilsson LA,Tarkowski A,Werner N

    更新日期:1989-01-01 00:00:00

  • Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses.

    abstract:OBJECTIVES:To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing T2DM (LSDM)) and pancreatic cancer (PC) risk, to explore the direction of causation through Mendelian randomisation (MR) analysis and to assess the mediation role of body mass index (BMI)....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-319990

    authors: Molina-Montes E,Coscia C,Gómez-Rubio P,Fernández A,Boenink R,Rava M,Márquez M,Molero X,Löhr M,Sharp L,Michalski CW,Farré A,Perea J,O'Rorke M,Greenhalf W,Iglesias M,Tardón A,Gress TM,Barberá VM,Crnogorac-Jurcevic T,

    更新日期:2021-02-01 00:00:00

  • Jejunal bacterial overgrowth and intestinal permeability in children with immunodeficiency syndromes.

    abstract::Seventeen paediatric patients with immunodeficiency syndromes (10 with selective IgA deficiency, four with panhypogammaglobulinaemia, and three with selective T cell deficiency) were investigated for bacterial overgrowth of the small intestine and gut permeability to macromolecules. Five of 12 patients showed viable b...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.8.879

    authors: Pignata C,Budillon G,Monaco G,Nani E,Cuomo R,Parrilli G,Ciccimarra F

    更新日期:1990-08-01 00:00:00

  • Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor.

    abstract::The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approxi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.11.1234

    authors: Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

    更新日期:1984-11-01 00:00:00

  • Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum.

    abstract:BACKGROUND AND AIMS:Interstitial cells of Cajal (ICC) are pacemakers and mediators of motor neurotransmission in gastrointestinal smooth muscles. ICC require cellular signalling via Kit, a receptor tyrosine kinase, for development and maintenance of phenotype. Much of the evidence demonstrating the functions of ICC com...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.50.6.790

    authors: Takayama I,Daigo Y,Ward SM,Sanders KM,Walker RL,Horowitz B,Yamanaka T,Fujino MA

    更新日期:2002-06-01 00:00:00

  • Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study.

    abstract:BACKGROUND:Wilson's disease is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. Clinical data on larger cohorts are limited owing to low disease frequency. OBJECTIVE AND METHODS:We performed a retrospective analysis of 163 patients with Wilson's disease,...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.087262

    authors: Merle U,Schaefer M,Ferenci P,Stremmel W

    更新日期:2007-01-01 00:00:00

  • Pseudotumoral enterocolitis and massive eosinophilia.

    abstract::We report a seven year history of a 23 year old woman born in the Antilles, with pseudotumoral enterocolitis and massive eosinophilia. In 1973 she developed a haemorrhagic colitis with massive peripheral eosinophilia of up to 60000/mm3. Medical treatment, mainly corticosteroids, failed to control the disease. The pati...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.24.4.345

    authors: Malè PJ,de Toledo F,Widgren S,de Peyer R,Berthoud S

    更新日期:1983-04-01 00:00:00

  • Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery.

    abstract::An endoscopical and histological study was carried out in 114 patients, treated by 'curative' resection of the terminal ileum and part of the colon for Crohn's disease, in order to study the natural history of recurrent Crohn's disease. The recurrence rate of Crohn's disease in patients examined within one year of the...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.6.665

    authors: Rutgeerts P,Geboes K,Vantrappen G,Kerremans R,Coenegrachts JL,Coremans G

    更新日期:1984-06-01 00:00:00

  • Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis.

    abstract:BACKGROUND:Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS:We conducted a randomised, double blind, placebo controlled trial of intravenous ant...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2006.115873

    authors: Siriwardena AK,Mason JM,Balachandra S,Bagul A,Galloway S,Formela L,Hardman JG,Jamdar S

    更新日期:2007-10-01 00:00:00

  • Increased risk and case fatality rate of pyogenic liver abscess in patients with liver cirrhosis: a nationwide study in Denmark.

    abstract:BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.2.260

    authors: Mølle I,Thulstrup AM,Vilstrup H,Sørensen HT

    更新日期:2001-02-01 00:00:00

  • In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies.

    abstract:BACKGROUND:IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.024836

    authors: Korponay-Szabó IR,Halttunen T,Szalai Z,Laurila K,Király R,Kovács JB,Fésüs L,Mäki M

    更新日期:2004-05-01 00:00:00

  • Immunoelectrophoretic studies on human small intestinal brush border proteins--amount of lactase protein in adult-type hypolactasia.

    abstract::Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immun...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.5.360

    authors: Skovbjerg H,Gudmand-Høyer E,Fenger HJ

    更新日期:1980-05-01 00:00:00