Inhibitory effect of unconjugated bile acids on the intestinal transport of 5-methyltetrahydrofolate in rat jejunum in vitro.

abstract：:Options for managing the common bile duct during laparoscopic cholecystectomy include routine peroperative cholangiography and selected preoperative endoscopic retrograde cholangiopancreatography (ERCP). The use of these methods was reviewed in 350 patients with symptomatic gall stones referred for laparoscopic cholec...

journal_title：Gut

authors： Hainsworth PJ,Rhodes M,Gompertz RH,Armstrong CP,Lennard TW

更新日期：1994-07-01 00:00:00

abstract：:Although a high prevalence of antibodies to Helicobacter pylori has been documented within families, culture and DNA typing of strains from infected children and their parents has not been evaluated. This study aimed to analyse H pylori infection within family groups. Endoscopy, gastric biopsy, and H pylori culture we...

journal_title：Gut

authors： Bamford KB,Bickley J,Collins JS,Johnston BT,Potts S,Boston V,Owen RJ,Sloan JM

更新日期：1993-10-01 00:00:00

abstract：:Serumfolate folate levels and the bacteriology of the small intestine were studied in 13 patients with jejunal diverticulosis, 29 patients with partial gastrectomy, and five patients with ileal disease. The mean serum folate level in the patients with partial gastrectomy (7.2 mmug/ml) was similar to that of control su...

journal_title：Gut

authors： Hoffbrand AV,Tabaqchali S,Booth CC,Mollin DL

更新日期：1971-01-01 00:00:00

abstract：:The feasibility of surgery in amoebic colitis is presented by illustrative case histories in two patients. Subtotal colectomy and ileostomy were carried out for fulminating colitis in the one and exteriorization, excision, and subsequent re-anastomosis of a localized perforated area of bowel in the other. It is sugges...

journal_title：Gut

authors： Stein D,Bank S

更新日期：1970-11-01 00:00:00

abstract：:Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were r...

journal_title：Gut

authors： Schröder H,Evans DA

更新日期：1972-04-01 00:00:00

abstract：:The role of Helicobacter pylori infection in the pathogenesis of functional dyspepsia is debated. It is known that a substantial fraction of dyspeptic patients manifest a low discomfort threshold to gastric distension. This study investigated the symptomatic pattern in 27 H pylori positive and 23 H pylori negative pat...

journal_title：Gut

authors： Mearin F,de Ribot X,Balboa A,Salas A,Varas MJ,Cucala M,Bartolomé R,Armengol JR,Malagelada JR

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...

journal_title：Gut

authors： Gyr K,Meier R,Häussler J,Boulétreau P,Fleig WE,Gatta A,Holstege A,Pomier-Layrargues G,Schalm SW,Groeneweg M,Scollo-Lavizzari G,Ventura E,Zeneroli ML,Williams R,Yoo Y,Amrein R

更新日期：1996-08-01 00:00:00

abstract：:The use of tripotassium dicitrato bismuthate (TDB) has been suggested recently for cimetidine resistant duodenal ulcers. This study compares the efficacy of TDB with two different cimetidine dosages in the treatment of duodenal ulcer patients who failed to respond to an eight week therapy with H2-blockers. Fifty two p...

journal_title：Gut

authors： Bianchi Porro G,Parente F,Lazzaroni M

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...

journal_title：Gut

authors： Vasen HF,van Duijvendijk P,Buskens E,Bülow C,Björk J,Järvinen HJ,Bülow S

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:There is considerable evidence indicating that the severity of hepatic damage in individuals with cholestatic liver disease is causally associated with the extent of intrahepatic oxidative stress. Increased levels or accelerated generation of reactive oxygen species and toxic degradative products of lipid pe...

journal_title：Gut

authors： Ljubuncic P,Tanne Z,Bomzon A

更新日期：2000-11-01 00:00:00

abstract：:The extent to which monitoring breath hydrogen excretion provides information concerning the entry of the residues of a solid test meal into the colon was investigated in 89 normal subjects, and 11 patients with the irritable bowel syndrome. The profile of breath hydrogen concentration showed an early peak, that occur...

journal_title：Gut

authors： Read NW,Al-Janabi MN,Bates TE,Holgate AM,Cann PA,Kinsman RI,McFarlane A,Brown C

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...

journal_title：Gut

authors： Cravo M,Pinto R,Fidalgo P,Chaves P,Glória L,Nobre-Leitão C,Costa Mira F

更新日期：1996-09-01 00:00:00

abstract：:Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absenc...

journal_title：Gut

authors： Robinson DC,Watson AJ,Wyatt EH,Marks JM,Roberts DF

更新日期：1971-10-01 00:00:00

abstract：:This paper describes opacification and identification of two surgically constructed pancreatico-jujunal shunts. A fibreoptic panendoscope was used with retrograde injection via the ampulla of Vater (ERCP). This procedure makes possible more accurate anatomical evaluation and so more precise clinical appraisal of both...

journal_title：Gut

authors： Miller EW,Goldberg HI,Goldberg SB,Shapiro H

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS:We conducted a randomised, double blind, placebo controlled trial of intravenous ant...

journal_title：Gut

authors： Siriwardena AK,Mason JM,Balachandra S,Bagul A,Galloway S,Formela L,Hardman JG,Jamdar S

更新日期：2007-10-01 00:00:00

abstract：:Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute ...

journal_title：Gut

authors： Hobsley M,Silen W

更新日期：1969-10-01 00:00:00

abstract：BACKGROUND:Hereditary pancreatitis (HP) is a rare autosomal dominant disorder with variable expression and an overall lifetime penetrance of 80%. We hypothesised that (1) monozygotic twins within similar environments would develop the typical signs of HP at a similar age, and (2) if penetrance were due to modifier gene...

journal_title：Gut

authors： Amann ST,Gates LK,Aston CE,Pandya A,Whitcomb DC

更新日期：2001-04-01 00:00:00

abstract：:Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients. Of the 71 NCCP patients, 35 had a positive AP test (of whom 20 ha...

journal_title：Gut

authors： Hewson EG,Sinclair JW,Dalton CB,Wu WC,Castell DO,Richter JE

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Murine postoperative ileus results from intestinal inflammation triggered by manipulation-induced mast cell activation. As its extent depends on the degree of handling and subsequent inflammation, it is hypothesised that the faster recovery after minimal invasive surgery results from decreased mast cell acti...

journal_title：Gut

authors： The FO,Bennink RJ,Ankum WM,Buist MR,Busch OR,Gouma DJ,van der Heide S,van den Wijngaard RM,de Jonge WJ,Boeckxstaens GE

更新日期：2008-01-01 00:00:00

abstract：:Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The t...

journal_title：Gut

authors： Hodgson HJ,Jewell DP

更新日期：1977-08-01 00:00:00

abstract：:This paper describes the construction and use of "radio pills" which transmit changes in intraluminar pressure. ...

journal_title：Gut

authors： CONNELL AM,ROWLANDS EN

更新日期：1960-09-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：:This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...

journal_title：Gut

authors： NEFZGER MD,ACHESON ED

更新日期：1963-06-01 00:00:00

abstract：OBJECTIVE:Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowle...

journal_title：Gut

authors： Luthra P,Burr NE,Brenner DM,Ford AC

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Postpolypectomy surveillance guidelines for colorectal cancer introduced the concept of 'risk stratification'; however, few studies have been conducted for validation of its usefulness. The aim of this study was to assess the 5-year incidence of advanced neoplasia recurrence based on the risk stratification s...

journal_title：Gut

authors： Chung SJ,Kim YS,Yang SY,Song JH,Kim D,Park MJ,Kim SG,Song IS,Kim JS

更新日期：2011-11-01 00:00:00

abstract：AIM:To compare acceptability and diagnostic accuracy of a recently available faecal immunochemical test (FIT) system (HM-JACKarc) with the FIT routinely used in an established screening programme (OC-Sensor). DESIGN:Randomised controlled trial (ISRCTN20086618) within a population-based colorectal cancer (CRC) screenin...

journal_title：Gut

authors： Passamonti B,Malaspina M,Fraser CG,Tintori B,Carlani A,D'Angelo V,Galeazzi P,Di Dato E,Mariotti L,Bulletti S,D'Amico MR,Gustinucci D,Martinelli N,Spita N,Cesarini E,Rubeca T,Giaimo M,Segnan N,Senore C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS:We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk ...

journal_title：Gut

authors： Mocellin S,Verdi D,Pooley KA,Nitti D

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Emerging evidence from mouse models suggests that mutant Kras can drive the development of pancreatic ductal adenocarcinoma (PDA) precursors from acinar cells by enforcing ductal de-differentiation at the expense of acinar identity. Recently, human genome-wide association studies have identified NR5A2, a key...

journal_title：Gut

authors： von Figura G,Morris JP 4th,Wright CV,Hebrok M

更新日期：2014-04-01 00:00:00

abstract：:4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...

journal_title：Gut

authors： Schreiber S,Howaldt S,Raedler A

更新日期：1994-08-01 00:00:00