Five-year risk for advanced colorectal neoplasia after initial colonoscopy according to the baseline risk stratification: a prospective study in 2452 asymptomatic Koreans.


OBJECTIVE:Postpolypectomy surveillance guidelines for colorectal cancer introduced the concept of 'risk stratification'; however, few studies have been conducted for validation of its usefulness. The aim of this study was to assess the 5-year incidence of advanced neoplasia recurrence based on the risk stratification scheme of the guidelines and to identify its risk factors. METHODS:A prospective study of surveillance colonoscopy after screening colonoscopy was carried out at the Seoul National University Hospital Healthcare System Gangnam Center. 3803 asymptomatic Koreans aged 50-69 were enrolled prospectively and 5-year cumulative adenoma rates were analysed according to three risk groups: normal (no baseline adenoma), low-risk (1-2 adenomas <10 mm) and high-risk (an advanced adenoma or ≥ 3 adenomas) groups. The RR was computed by HR using Cox proportional regression after multivariate adjustments. The primary outcome was the 5-year cumulative rate of recurrent advanced adenoma in each risk category and the secondary outcome was its predictive factors. RESULTS:Among 3803 subjects enrolled between 2003 and 2005, 2452 were followed-up within 5 years: 1242, 671 and 539 in the normal, low-risk and high-risk groups, respectively. Compared with the normal group, the low-risk group had a sufficiently low 5-year incidence and did not show an increased risk for subsequent advanced adenoma (2.4% vs 2.0%, HR=1.14, 95% CI 0.61 to 2.17). Conversely, a significantly higher 5-year rate (12.2%) and early recurrence (4.6, 7.4 and 9.6% at 1, 2 and 3 years) of advanced adenoma were revealed in the high-risk group. Among various patients and adenoma characteristics, only high-risk adenoma (HR=5.95, 95% CI 3.66 to 9.68) along with a number of ≥ 3 (HR=3.06, 95% CI 1.51 to 6.57) and size ≥ 10 mm (HR=3.02, 95% CI 1.80 to 5.06) were independent predictors. CONCLUSIONS:The surveillance interval for low-risk patients could be extended beyond 5 years. Colonoscopic surveillance should be targeted to high-risk patients, and 3-year follow-up after initial polypectomy may be appropriate.






Chung SJ,Kim YS,Yang SY,Song JH,Kim D,Park MJ,Kim SG,Song IS,Kim JS




Has Abstract


2011-11-01 00:00:00
















  • Comparison of bismuth citrate and 5-aminosalicylic acid enemas in distal ulcerative colitis: a controlled trial.

    abstract::An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Pullan RD,Ganesh S,Mani V,Morris J,Evans BK,Williams GT,Rhodes J

    更新日期:1993-05-01 00:00:00

  • Gastric, pancreatic, and biliary responses to meals in hyperthyroidism.

    abstract::Upper gastrointestinal function in response to a mixed nutrient meal was evaluated in hyperthyroid patients, both before and after therapy, and in healthy controls. Gastric secretion, gastric emptying, and pancreatic secretion were all normal and normally integrated postprandially in the hyperthyroid patients. Bile ac...


    pub_type: 杂志文章


    authors: Miller LJ,Owyang C,Malagelada JR,Gorman CA,Go VL

    更新日期:1980-08-01 00:00:00

  • Dietary nucleotides and gut mucosal defence.

    abstract::The informational aspects of nucleic acid synthesis have attracted much more attention than the quantitative significance of DNA, rRNA, tRNA, and nucleotide synthesis. Animal and human studies suggest that in energetic terms, 5-10% of the energy used in synthesising tissue protein is expended in manufacturing an appro...


    pub_type: 杂志文章,评审


    authors: Grimble GK

    更新日期:1994-01-01 00:00:00

  • Diffuse enterochromaffin-like (ECL) cell hyperplasia and multiple gastric carcinoids: a complication of pernicious anaemia.

    abstract::A man with long-standing pernicious anaemia developed multiple gastric carcinoid tumours with a background of diffuse enterochromaffin-like cell hyperplasia. There is evidence that enterochromaffin-like cells synthesis and store histamine and that their proliferation is stimulated by high serum gastrin levels. Gastric...


    pub_type: 杂志文章


    authors: Hodges JR,Isaacson P,Wright R

    更新日期:1981-03-01 00:00:00

  • Detection of small hepatocellular carcinomas in cirrhotic livers using iodised oil computed tomography.

    abstract:BACKGROUND:The detection of hepatocellular cancers (HCC) is a major role of preoperative imaging in patients with end stage liver disease being considered for orthotopic liver transplantation (OLT). AIMS:To assess the sensitivity of iodised oil computed tomography (IOCT). PATIENTS AND METHODS:A prospective evaluation...


    pub_type: 杂志文章


    authors: Saada J,Bhattacharya S,Dhillon AP,Dick R,Burroughs AK,Rolles K,Davidson BR

    更新日期:1997-09-01 00:00:00

  • Determination of liver volume by the use of a gamma camera connected with 1600 or 4096 channel analyser in diffuse liver diseases.

    abstract::A method of in vivo calculation of liver volume using a gamma camera and a 1600 or 4096 channel analyser is described. Topographically, the maximum thickness giving the highest counts in matrix data in the right anterior oblique projection is measured as the maximum breadth in the right posterior oblique projection. T...


    pub_type: 杂志文章,评审


    authors: Fujii M,Mukai T,Yamamoto T,Wakisaka G

    更新日期:1976-04-01 00:00:00

  • Prospective study of physical activity and the risk of symptomatic diverticular disease in men.

    abstract::The relationship between physical activity and risk of symptomatic diverticular disease has not been investigated directly. This association was examined in a prospective cohort of 47,678 American men, 40 to 75 years of age, and free of diagnosed diverticular disease, colon or rectal polyp, ulcerative colitis, and can...


    pub_type: 杂志文章


    authors: Aldoori WH,Giovannucci EL,Rimm EB,Ascherio A,Stampfer MJ,Colditz GA,Wing AL,Trichopoulos DV,Willett WC

    更新日期:1995-02-01 00:00:00

  • Primary ileal villous atrophy is often associated with microscopic colitis.

    abstract::Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...


    pub_type: 杂志文章,评审


    authors: Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JC

    更新日期:1997-10-01 00:00:00

  • Rôle of calcitonin in diarrhoea associated with medullary carcinoma of the thyroid.

    abstract::Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the eff...


    pub_type: 杂志文章


    authors: Cox TM,Fagan EA,Hillyard CJ,Allison DJ,Chadwick VS

    更新日期:1979-07-01 00:00:00

  • Composition of gastro-oesophageal refluxate.

    abstract::Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...


    pub_type: 杂志文章


    authors: Gotley DC,Morgan AP,Ball D,Owen RW,Cooper MJ

    更新日期:1991-10-01 00:00:00

  • Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice.

    abstract:OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...


    pub_type: 杂志文章


    authors: Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

    更新日期:2020-09-01 00:00:00

  • Autoimmune hepatitis: a histological variant associated with prominent centrilobular necrosis.

    abstract::A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisti...


    pub_type: 杂志文章


    authors: Te HS,Koukoulis G,Ganger DR

    更新日期:1997-08-01 00:00:00

  • Exocrine pancreatic insufficiency: accuracy and clinical value of the uniformly labelled 13C-Hiolein breath test.

    abstract:BACKGROUND AND AIMS:The 13C-Hiolein breath test (98% [U-13C] labelled long chain triglyceride mixture (highly labelled triolein) was evaluated as a non-invasive, non-radioactive test for exocrine pancreatic insufficiency. Accuracy and clinical validity were examined with reference to both the secretin pancreozymin test...


    pub_type: 杂志文章


    authors: Lembcke B,Braden B,Caspary WF

    更新日期:1996-11-01 00:00:00

  • Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma.

    abstract:BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...


    pub_type: 杂志文章


    authors: Cravo M,Pinto R,Fidalgo P,Chaves P,Glória L,Nobre-Leitão C,Costa Mira F

    更新日期:1996-09-01 00:00:00

  • Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial barrier dysfunction in vivo.

    abstract:BACKGROUND AND AIMS:Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation. In addition, Fer participates in cytoskeletal interactions mediated by cadherins, platelet endothelial cell adhesion molecule 1 (PECAM-1),...


    pub_type: 杂志文章


    authors: Qi W,Ebbert KV,Craig AW,Greer PA,McCafferty DM

    更新日期:2005-08-01 00:00:00

  • Problems in diagnosing viral hepatitis.

    abstract::The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...


    pub_type: 杂志文章


    authors: Bonino F,Colloredo Mels G,Bellati G,Ideo G,Oliveri F,Colombatto P,Brunetto MR

    更新日期:1993-01-01 00:00:00

  • Fine needle aspiration cytology of rectal masses.

    abstract::This paper describes the results of transproctoscopic fine needle aspiration cytology in the diagnosis of rectal lesions. Fifty one consecutive patients referred with a presumptive diagnosis of rectal mass were subjected to proctoscopic examination when fine needle aspiration cytology, brush cytology and biopsy sample...


    pub_type: 杂志文章


    authors: Kochhar R,Rajwanshi A,Wig JD,Gupta NM,Kesiezie V,Bhasin DK,Malik AK,Gupta SK,Mehta SK

    更新日期:1990-03-01 00:00:00

  • T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease.

    abstract:BACKGROUND AND AIMS:Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn's disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to investigate the role...


    pub_type: 杂志文章


    authors: Matsuoka K,Inoue N,Sato T,Okamoto S,Hisamatsu T,Kishi Y,Sakuraba A,Hitotsumatsu O,Ogata H,Koganei K,Fukushima T,Kanai T,Watanabe M,Ishii H,Hibi T

    更新日期:2004-09-01 00:00:00

  • Effect of peptide histidine isoleucine on water and electrolyte transport in the human jejunum.

    abstract::Peptide histidine isoleucine, a 27 amino acid peptide with close amino acid sequence homology to vasoactive intestinal peptide and secretin, is distributed throughout the mammalian intestinal tract, where it has been localised to intramural neurones. An intestinal perfusion technique has been used to study the effect ...


    pub_type: 杂志文章


    authors: Moriarty KJ,Hegarty JE,Tatemoto K,Mutt V,Christofides ND,Bloom SR,Wood JR

    更新日期:1984-06-01 00:00:00

  • Fluoroscopically guided laser lithotripsy versus extracorporeal shock wave lithotripsy for retained bile duct stones: a prospective randomised study.

    abstract:BACKGROUND AND AIMS:To compare extracorporeal shock wave lithotripsy (ESWL) and laser induced shock wave lithotripsy (LISL) of retained bile duct stones to stone free rate, number of therapeutic sessions, and costs. PATIENTS:Thirty four patients were randomly assigned to either ESWL or LISL therapy. The main reasons f...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jakobs R,Adamek HE,Maier M,Krömer M,Benz C,Martin WR,Riemann JF

    更新日期:1997-05-01 00:00:00

  • Relationship between pancreatic secretion and pancreatic blood flow.

    abstract::An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin. Secretin resulted in the production of a large volume of low viscous pancreatic juice and was associated with an increase in the cardia...


    pub_type: 杂志文章


    authors: Goodhead B,Himal HS,Zanbilowicz J

    更新日期:1970-01-01 00:00:00

  • Management of bleeding oesophageal varices by draining lymph from the thoracic duct.

    abstract::The thoracic duct was cannulated in six patients who were actively bleeding from varices and had not responded to conservative treatment but draining lymph from the thoracic duct did not control bleeding in five patients. There was no drop in intrasplenic pulp pressure following this procedure when recorded in three o...


    pub_type: 杂志文章


    authors: Datta DV,Singh SA,Patra BS,Saini VK,Chhuttani PN

    更新日期:1971-01-01 00:00:00

  • Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor.

    abstract::The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approxi...


    pub_type: 杂志文章


    authors: Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

    更新日期:1984-11-01 00:00:00

  • Colonic mass movements in idiopathic chronic constipation.

    abstract::As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...


    pub_type: 杂志文章


    authors: Bassotti G,Gaburri M,Imbimbo BP,Rossi L,Farroni F,Pelli MA,Morelli A

    更新日期:1988-09-01 00:00:00

  • Lymphocyte subpopulations in adult coeliac disease.

    abstract::Rosetting techniques were used to estimate T and B cell subpopulations in the peripheral blood in patients with treated and untreated adult coeliac disease and in control subjects. In patients with untreated coeliac disease, T cell numbers were significantly lower than in controls or treated patients, although there w...


    pub_type: 杂志文章


    authors: Bullen AW,Losowsky MS

    更新日期:1978-10-01 00:00:00

  • Intestinal function and intestinal blood supply: a 20 year surgical study.

    abstract::The experience of The Middlesex Hospital in the investigation and management of chronic intestinal arterial occlusion (IAO) over a 20 year period is presented. Of some 100 patients referred only 28 were found to have IAO and these were critically evaluated in terms of insorptive and exsorptive function. No relation wa...


    pub_type: 杂志文章


    authors: Marston A,Clarke JM,Garcia Garcia J,Miller AL

    更新日期:1985-07-01 00:00:00

  • Faecal alpha-1-antitrypsin and excretion of 111indium granulocytes in assessment of disease activity in chronic inflammatory bowel diseases.

    abstract::Intestinal protein loss in chronic inflammatory bowel diseases may be easily determined by measurement of alpha-1-antitrypsin (alpha 1-AT) stool concentration and alpha 1-AT clearance. Both parameters were significantly raised in 36 and 34 patients respectively with chronic inflammatory bowel diseases, compared with e...


    pub_type: 杂志文章


    authors: Fischbach W,Becker W,Mössner J,Koch W,Reiners C

    更新日期:1987-04-01 00:00:00

  • Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice.

    abstract:OBJECTIVE:Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we pro...


    pub_type: 杂志文章


    authors: Perez-Pardo P,Dodiya HB,Engen PA,Forsyth CB,Huschens AM,Shaikh M,Voigt RM,Naqib A,Green SJ,Kordower JH,Shannon KM,Garssen J,Kraneveld AD,Keshavarzian A

    更新日期:2019-05-01 00:00:00

  • Effect of dietary nucleotides on small intestinal repair after diarrhoea. Histological and ultrastructural changes.

    abstract::The effects of specific nutrients on intestinal maturation and repair after injury are practically unknown. The purpose of this work was to study the effects of dietary nucleotides on the repair of the intestinal mucosa after chronic diarrhoea induced by a lactose enriched diet in the weanling rat. One group of weanli...


    pub_type: 杂志文章


    authors: Bueno J,Torres M,Almendros A,Carmona R,Nuñez MC,Rios A,Gil A

    更新日期:1994-07-01 00:00:00

  • Analgesic ingestion and other factors preceding relapse in ulcerative colitis.

    abstract::To investigate factors which predispose to relapse in patients with ulcerative colitis, we conducted a survey to compare the events occurring in the four weeks preceding the clinic attendance of 62 outpatients in remission with those taking place in the same period before the onset of relapse in 21 patients attending ...


    pub_type: 杂志文章


    authors: Rampton DS,McNeil NI,Sarner M

    更新日期:1983-03-01 00:00:00