Abstract:
BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bladder motility) in HTG patients. PATIENTS AND METHODS:Gall bladder motility (ultrasonography) was studied postprandially and during infusion of cholecystokinin (CCK). Determinants of cholelithiasis and serum lipids were compared between nine HTG patients and 10 age, sex, and body mass index matched normolipidaemic controls. The effects of bezafibrate and fish oil in HTG patients were studied in a randomised cross over trial. RESULTS:HTG patients showed 14-fold higher serum triglyceride (TG) levels than controls. Biliary lipid composition, fasting gall bladder volumes, and CCK levels did not differ between HTG patients and controls. Gall bladder emptying was reduced in HTG patients compared with controls during CCK infusion (-22%) as well as in response to a meal (-37%; both p<0.001). Postprandial CCK levels were significantly higher in HTG patients. Both bezafibrate and fish oil reduced serum TG levels (-68% and -51% v baseline, respectively; both p<0.01). Fasting CCK levels were not affected whereas CCK induced gall bladder emptying increased during bezafibrate (+29%; p<0.001) and tended to increase on fish oil therapy (+13%; p=0.07). Postprandial gall bladder motility improved on bezafibrate and fish oil (+47 and +25% v baseline, respectively; both p<0.02) at least partly due to increased gall bladder sensitivity to CCK (both p<0.05 v baseline). Bezafibrate but not fish oil increased the molar ratio of cholesterol to bile acids (+40%; p=0.05) but no effects on cholesterol saturation index were seen with either treatment. CONCLUSIONS:We suggest that impaired gall bladder motility occurs in HTG patients due to decreased sensitivity to CCK, which may add to the enhanced risk of gall stone disease in HTG patients. Triglyceride lowering therapy by both fish oil and bezafibrate improve gall bladder dysmotility without adversely affecting biliary cholesterol saturation.
journal_name
Gutjournal_title
Gutauthors
Jonkers IJ,Smelt AH,Ledeboer M,Hollum ME,Biemond I,Kuipers F,Stellaard F,Boverhof R,Meinders AE,Lamers CH,Masclee AAdoi
10.1136/gut.52.1.109keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
109-15issue
1eissn
0017-5749issn
1468-3288journal_volume
52pub_type
临床试验,杂志文章,随机对照试验相关文献
GUT文献大全abstract:OBJECTIVES:Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306302
更新日期:2015-07-01 00:00:00
abstract:AIMS:To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. METHODS:150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.45.4.588
更新日期:1999-10-01 00:00:00
abstract:AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.288
更新日期:1998-08-01 00:00:00
abstract::The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.2...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.3.270
更新日期:1991-03-01 00:00:00
abstract::The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of the greater curvature of the stomach mounted in a double lumen chamber. This model permitted simultaneous evaluation of two seg...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.9.775
更新日期:1978-09-01 00:00:00
abstract:OBJECTIVE:miR-21 was found to be overexpressed in the colon tissues and serum of patients with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis-associated CRC remain unclear. The aim of our study was to investigate the biological mechanisms of miR-21 in colitis-associated colon cancer (CAC)...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308455
更新日期:2016-09-01 00:00:00
abstract::The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Crypt...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.8.1057
更新日期:1992-08-01 00:00:00
abstract::The aim of this study was to develop and validate an endoscopic index for assessing the severity of Crohn's disease. Endoscopic findings were prospectively collected by a multicentre group in 75 patients with Crohn's colitis according to a previously validated procedure. The presence of nine preselected lesions was re...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gut.30.7.983
更新日期:1989-07-01 00:00:00
abstract::It has been demonstrated that cardiac output and pulmonary, gastroduodenal, pancreatic, and splenic blood flow increases after portacaval shunt operations. This report concerns a study of cerebral haemodynamics and metabolism in eight patients with cirrhosis of the liver, examined both before and after portacaval surg...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.11.894
更新日期:1969-11-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNA) have potential as prognostic biomarkers and therapeutic targets in cancer. A study was undertaken to investigate the association between miRNA expression patterns and the prognosis and therapeutic outcome of colorectal cancer (CRC). METHODS:miRNA expression profiling in tumour, adenoma and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301122
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311224
更新日期:2017-03-01 00:00:00
abstract::The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, wi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.1.70
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers. METH...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309642
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Targeting tumour necrosis factor alpha (TNF-alpha) has demonstrated efficacy in Crohn's disease. AIM:To evaluate CDP571, a humanised antibody to TNF-alpha, for treating active Crohn's disease. PATIENTS:A total of 396 patients with moderate to severe Crohn's disease. METHODS:In a 28 week, randomised, doubl...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2003.035253
更新日期:2004-10-01 00:00:00
abstract::Colonic exfoliated epithelial cells in faecal material provide a source of human DNA which has been analysed for the presence of the tumour marker ras, in order to detect early tumour cells. The stool samples were subjected to a preliminary sample preparation step followed by centrifugation. DNA was extracted from bot...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.1.81
更新日期:1995-01-01 00:00:00
abstract::Options for managing the common bile duct during laparoscopic cholecystectomy include routine peroperative cholangiography and selected preoperative endoscopic retrograde cholangiopancreatography (ERCP). The use of these methods was reviewed in 350 patients with symptomatic gall stones referred for laparoscopic cholec...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.35.7.991
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Invasion of the intestinal mucosa by leucocytes is a characteristic of intestinal inflammation but the role of the epithelium in orchestrating this recruitment has not been examined in vivo. Cultured intestinal epithelial cells secrete a wide variety of chemokines, often in response to agents present in the ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.4.526
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC. DESIGN:Transcriptional profiling of 273 formalin-fixed paraffin-...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317624
更新日期:2019-11-01 00:00:00
abstract::The distribution of the endoplasmic reticulum in human hepatocytes is defined in quantitative terms using the techniques of morphometry. The subjects of the study are liver biopsies from normal, untreated subjects and patients being treated with various drugs. In contrast to rat hepatocytes, the amount of smooth endop...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.9.737
更新日期:1974-09-01 00:00:00
abstract::This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.4.2.183
更新日期:1963-06-01 00:00:00
abstract::The isoenzyme pattern of lactic dehydrogenase was measured in rectal biopsies from six patients with ulcerative colitis in whom precancerous histological changes had been independently recognized. There was a highly significant increase in the ratio of isoenzymes IV + V to I + II. This suggests that lactic dehydrogena...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.1.16
更新日期:1971-01-01 00:00:00
abstract:OBJECTIVE:Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal perm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-305690
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2011-301265
更新日期:2013-02-01 00:00:00
abstract::Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.8.699
更新日期:1978-08-01 00:00:00
abstract::The cause of a biliary tract stricture may be difficult to determine radiologically. Exfoliative biliary cytology was evaluated in 62 patients (median age 65 years, range 30-94) with biliary tract strictures presenting to the Hepatobiliary Unit between January 1984 and December 1989. Bile samples were taken during end...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.10.1408
更新日期:1992-10-01 00:00:00
abstract::Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.41.4.561
更新日期:1997-10-01 00:00:00
abstract::The aims of the present study were to determine the relative amplitudes of intragastric motor responses evoked by different vagal branches and to establish whether the effects of acute or chronic vagotomy could be predicted from these data. Intragastric pressure responses to electrical stimulation of the vagus were me...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.10.811
更新日期:1980-10-01 00:00:00
abstract::The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.9.750
更新日期:1979-09-01 00:00:00
abstract::A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.3.459
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were sp...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.6.803
更新日期:2002-12-01 00:00:00