Abstract:
:The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.25 g/l, 1.0 g/l, jejunum; 0.5 g/l, 1.0 g/l, ileum; sulphasalazine 0.25 g/l, 0.5 g/l, 2.0 g/l jejunum; 1.0 g/l, 2.0 g/l, ileum.) In the jejunum olsalazine at 1.0 g/l significantly inhibited water, sodium, chloride, and potassium absorption (p less than 0.05). In the ileum olsalazine at 0.5 and 1 g/l significantly inhibited glucose uptake (p less than 0.04) and water absorption (p less than 0.03). In the jejunum sulphasalazine had a dose related and significant inhibitory effect on water, bicarbonate, and sodium absorption and at 2.0 g/l an inhibitory effect on chloride, potassium (p less than 0.005), and glucose (p less than 0.05) absorption. In the ileum sulphasalazine had no significant effect on water and electrolyte absorption. All inhibitory effects were rapidly reversible. These data show that unexplained diarrhoea in patients with ulcerative colitis treated with olsalazine may occur as a consequence of inhibition of water and electrolyte absorption in the small intestine and that the mechanisms of inhibition of sulphasalazine and olsalazine are different.
journal_name
Gutjournal_title
Gutauthors
Raimundo AH,Patil DH,Frost PG,Silk DBdoi
10.1136/gut.32.3.270subject
Has Abstractpub_date
1991-03-01 00:00:00pages
270-4issue
3eissn
0017-5749issn
1468-3288journal_volume
32pub_type
杂志文章相关文献
GUT文献大全abstract::Results emerging from endoscopic treatments to ablate Barrett's oesophagus indicate that APC alone or ALA-PDT in combination with APC achieves complete clearance of Barrett's epithelium in approximately two thirds of patients. ...
journal_title:Gut
pub_type: 评论,杂志文章
doi:10.1136/gut.2003.036392
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-302423
更新日期:2013-04-01 00:00:00
abstract::Six jaundiced patients with primary sclerosing cholangitis and a dominant biliary stricture were managed by endoscopic placement of endoprostheses. Five showed considerable improvement within weeks of stenting: their serum bilirubin concentration fell from mean (range) 266 mumol/l (63-681) to 65 mumol/l (10-280) after...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.11.1364
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Activated hepatic stellate cells (HSCs) are an attractive target for antifibrotic therapy based on their key role in extracellular matrix accumulation during liver injury. AIM:: To develop a system for regulable and cell-specific gene expression in HSCs to enable targeted delivery of therapeutic genes. MET...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.085704
更新日期:2007-03-01 00:00:00
abstract::As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.9.1173
更新日期:1988-09-01 00:00:00
abstract::Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.9.696
更新日期:1976-09-01 00:00:00
abstract::Of 27 patients with liver disease and cryoglobulinaemia 18 proved to have paraproteins. Six of these monoclonal immunoglobulins were shown to have antibody activity, directed to human gamma globulin, alpha(1)-fetoprotein, smooth muscle, and mitochondria.Eight of the patients suffered from acute viral hepatitis, five o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.5.396
更新日期:1974-05-01 00:00:00
abstract:BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.2.201
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The authors' goal was to measure pH at the gastric surface (pH₀) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. METHODS:Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCEC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300420
更新日期:2012-06-01 00:00:00
abstract::The typical macroscopic features of Crohn's disease have been well described and are widely regarded as sufficient to diagnose the disease at laparotomy. We report six patients undergoing laparotomy for symptomatic Crohn's disease, shown radiologically, who were found to have macroscopically normal small bowel despite...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.1.140
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. The aim of the present study was to explore whether CTRC mutants indu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.198903
更新日期:2010-03-01 00:00:00
abstract::This study investigated the mechanisms by which TAGH solution (a mixture of triiodothyronine, amino acids, glucagon, and heparin) induces DNA synthesis in hepatocytes in the liver of intact rats, with particular reference to events at the epidermal growth factor (EGF) receptor. Both partial hepatectomy and infusion of...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.11.1601
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Cholangiocarcinoma cells express high levels of the antiapoptotic proteins Bcl-X(L) and Mcl-1 and are markedly chemo- and radioresistant. Mitochondria have emerged as central players in apoptosis. Antiapoptotic members of the Bcl-2 protein family localise to the outer mitochondrial membrane and regulate mito...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.4.556
更新日期:2002-10-01 00:00:00
abstract::Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception-that is, its relation to clinical symptoms-remains unclear. Data indicate that sensory dysfunction is associated with altered re...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.51.suppl_1.i25
更新日期:2002-07-01 00:00:00
abstract::A retrospective survey was undertaken of 228 resected Meckel's diverticula to determine if there was any evidence of Campylobacter pylori infection in diverticula containing gastric mucosa. Among the 65 diverticula with gastric mucosa one was heavily infected with organisms having the morphological appearances of C py...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.9.1233
更新日期:1989-09-01 00:00:00
abstract::Results from a recent, new assay suggest that omeprazole, a potent inhibitor of gastric acid secretion, is genotoxic. The principle of this assay is that the non-proliferating zone of surface gastric epithelial cells can be selectively removed by controlled digestion so that any incorporation of tritiated thymidine in...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2.235
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.6.878
更新日期:1998-06-01 00:00:00
abstract::A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.12.1660
更新日期:1993-12-01 00:00:00
abstract::The medication history of patients presenting with benign oesophageal stricture is compared with an age and sex matched control population selected from the community. Fifty five out of 151 consecutive admissions to a dysphagia clinic were found to have benign oesophageal stricture. Twenty six out of 53 (49%) had been...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.5.478
更新日期:1984-05-01 00:00:00
abstract::One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.3.246
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting. OBJECTIVE:To examine the association between green tea consumption and gastric cancer. METHODS:We anal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.166710
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.028779
更新日期:2004-05-01 00:00:00
abstract::Carriers of beta amino acids and imino acids in the small intestine of rabbits and guinea pigs are chloride dependent, and a cotransport of chloride, sodium, and 2-methyl-aminoisobutyric acid has been shown. This study examines the chloride dependence of amino acid transport in the human small intestine. The steady st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.2.215
更新日期:1995-02-01 00:00:00
abstract::Although colorectal cancer (CRC) is a common cause of cancer-related death, it is fortunately amenable to screening with faecal tests for occult blood and endoscopic tests. Despite the evidence for the efficacy of guaiac-based faecal occult blood tests (gFOBT), they have not been popular with primary care providers in...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2014-308074
更新日期:2015-08-01 00:00:00
abstract::A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.2.269
更新日期:1997-08-01 00:00:00
abstract::Patients with ulcerative colitis and coeliac disease who had been shown by impaired clearance of heat damaged red cells to have diminished splenic phagocytosis, were examined for evidence of more generalised reticuloendothelial malfunction by measuring their circulatory clearance of micro-aggregated albumin. Although ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.5.384
更新日期:1983-05-01 00:00:00
abstract::These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309262
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:miR-21 was found to be overexpressed in the colon tissues and serum of patients with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis-associated CRC remain unclear. The aim of our study was to investigate the biological mechanisms of miR-21 in colitis-associated colon cancer (CAC)...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308455
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319960
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bla...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.52.1.109
更新日期:2003-01-01 00:00:00