Abstract:
:The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Cryptosporidium had chronic diarrhoea. Most cases (63%) of chronic diarrhoea occurred in the first two years of life. A mild to moderate enteropathy was present in all nine children undergoing a small intestinal biopsy and seven showed the presence of Cryptosporidium adhering to villous epithelium. All patients eventually recovered spontaneously. Cryptosporidium is a cause of chronic diarrhoea and a proximal small intestinal mucosal enteropathy in children without immune deficiency. Screening for the parasite should be part of the investigative procedures in children with chronic diarrhoea.
journal_name
Gutjournal_title
Gutauthors
Phillips AD,Thomas AG,Walker-Smith JAdoi
10.1136/gut.33.8.1057keywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
1057-61issue
8eissn
0017-5749issn
1468-3288journal_volume
33pub_type
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