Abstract:
:Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of equal male: female ratio (n = 24) were fed alcohol by gavage twice daily to achieve a dosage of 15 g/kg body weight. Mean peak blood alcohol concentrations of 186 mg% were produced in males and 156 mg% in females. The animals were allowed free access to standard laboratory chow and water. Control animals were pair-fed to the alcoholic group and fed isocaloric glucose by gavage. Groups of animals were killed between 9 and 11 am on consecutive mornings, after nocturnal feeding, since it has previously been shown that fasting rapidly depletes hepatic glutathione concentrations. Hepatic glutathione was measured by a spectrophotometric enzymatic recycling procedure. As a marker of lipid peroxidation hepatic malonaldehyde (MDA) was measured by high performance liquid chromatography. Hepatic MDA was increased in the alcoholic group (p < 0.001), as was total hepatic glutathione (p < 0.0001). Plasma concentrations of alpha-tocopherol were increased in the alcoholic group, but ascorbic acid and superoxide dismutase values were not affected. No sex differences were detected. The increased MDA production in the alcohol group is strong evidence that lipid peroxidation is a mechanism of alcoholic tissue damage. The rise in hepatic glutathione may be an adaptive response to free radical production that protects the rat against tissue damage.
journal_name
Gutjournal_title
Gutauthors
Teare JP,Greenfield SM,Watson D,Punchard NA,Miller N,Rice-Evans CA,Thompson RPdoi
10.1136/gut.35.11.1644subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1644-7issue
11eissn
0017-5749issn
1468-3288journal_volume
35pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.4.563
更新日期:2003-04-01 00:00:00
abstract::To study the mechanism for the adaptive mucosal hyperplasia which occurs independent of luminal nutrition and pancreatico-biliary secretions in isolated Thiry-Vella segments of intestine from lactating rats, and to examine the effects of prolactin on small bowel mucosal structure in the rat, we used two models of expe...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.7.558
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Interleukin-6 (IL-6) is a well-recognised mediator of liver disease and regeneration. However, the in vivo effects of IL-6 on enterocytes and the intestinal tract have not been elucidated. We sought to determine the in vivo effects of IL-6 on enterocytes. METHODS:Murine models of increased or absen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.151175
更新日期:2010-02-01 00:00:00
abstract::An association between duodenal ulceration and a low fibre intake and a high refined carbohydrate diet has been reported. We therefore compared the current diet, smoking habits, social class, and possible other risk factors of 78 patients with duodenal ulcer and a community control group matched for age and sex. Logis...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.9.993
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal reservoir but very few data are available concerning the outcome for these patients. AIM:This study was designed to compare the o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.4.574
更新日期:1996-04-01 00:00:00
abstract::This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.3.3.252
更新日期:1962-09-01 00:00:00
abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311224
更新日期:2017-03-01 00:00:00
abstract::In a randomised clinical trial, patients with moderately active Crohn's disease received either prednisolone 0.5 mg/kg/day plus a normal diet, or an elemental diet plus oral framycetin, colistin and nystatin. Patients were assessed using the Crohn's disease activity index (CDAI), ESR, and faecal granulocyte excretion ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.26.10.994
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS:In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.3.351
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320839
更新日期:2020-12-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) levels have been measured in the serum of 490 patients and 93 normal controls using the double antibody radioimmunoassay technique. Levels were elevated in 71 of patients with carcinomata of the gastrointestinal tract and in 42% with other types of malignancy. In patients with non-neopla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.10.794
更新日期:1973-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066100
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C. DESIGN:We analysed 1461 patients with chronic hepatitis C with an estimat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-306997
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term eff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304370
更新日期:2014-03-01 00:00:00
abstract::It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.5.331
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:5-Lipoxygenase products play a part in inflammatory response. AIMS:The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. METHODS:Ninety rats with trinitrobenzenesulphonic acid induced colitis...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.6.899
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Motor disturbances are sometimes associated with diarrhoea by unknown mechanisms. AIM:To determine if there is a quantitative link between intestinal motility and epithelial secretion. SUBJECTS:Experiments were performed in 21 healthy volunteers and three patients with villus atrophy. METHODS:Duodenal and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.3.376
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Pancreatic acinar cell maturation is dependent on the activity of the pancreas transcription factor 1 (PTF1) complex. Induction of pancreatitis leads to MAP kinase activation and transient suppression of the acinar differentiation programme. We investigated the role of MAP kinase-interacting kinase 1 (Mnk1) i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306068
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316344
更新日期:2019-05-01 00:00:00
abstract::Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.8.644
更新日期:1977-08-01 00:00:00
abstract::The 13/14C-Urea breath test (UBT) is based on the simple principle that a solution of isotopically labelled urea will be rapidly hydrolysed by the abundantly expressed urease of H pylori. The released 13/14CO2 is absorbed across the mucus layer to the gastric mucosa and hence, via the systemic circulation, excreted in...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.43.2008.s47
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2019-318715
更新日期:2020-04-01 00:00:00
abstract::Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In norm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.10.817
更新日期:1977-10-01 00:00:00
abstract:UNLABELLED:Data on the natural history of elderly-onset inflammatory bowel disease (IBD) are scarce. METHODS:In a French population-based cohort we identified 841 IBD patients >60 years of age at diagnosis from 1988 to 2006, including 367 Crohn's disease (CD) and 472 ulcerative colitis (UC). RESULTS:Median age at dia...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-303864
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. AIMS:The aims of this study were to determine the normal distribution of ICC within the human colon and t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.4.496
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis. DESIGN:We performed miRNA microarrays using primary CRC tissues from patients with and without metastasis, and validated selected candida...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2015-309372
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers. AIMS:To elucidate the factor from H pylori that causes acceleration of a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.4.456
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE:To develop a set of multidisciplinary recommenda...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319300
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to gut-derived bacterial antigens is thought to be involved. Toll-like receptor ligands, especially lipopolysaccharide (LPS...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.128868
更新日期:2009-03-01 00:00:00
abstract::In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptom...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.3.299
更新日期:1993-03-01 00:00:00