Varicella-zoster virus DNA in the oesophageal myenteric plexus in achalasia.

Abstract:

:In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptoms who formed a control group. All titres were low, and those for herpes simplex type 1 virus and cytomegalovirus did not differ in the achalasia patients and the controls. However, the incidence of varicella-zoster virus antibodies was significantly greater in the achalasia than in the control group (p < 0.05). Using oesophageal tissue containing myenteric plexus removed at the time of cardiomyotomy in nine patients with achalasia, in situ DNA hybridisation showed evidence of varicella-zoster virus in three, but all were negative for the other two viruses. No positive results were obtained for herpes simplex type 1 virus, cytomegalovirus, or varicella-zoster virus in oesophageal tissue from 20 patients undergoing oesophageal resection for diseases other than achalasia. The incidence of positivity for varicella-zoster virus was significantly increased in the achalasia group compared with the controls (p < 0.02). The findings indicate that varicella-zoster virus DNA may persist in the oesophageal myenteric plexus in some patients with achalasia and raise the possibility that this virus is of aetiological importance in achalasia.

journal_name

Gut

journal_title

Gut

authors

Robertson CS,Martin BA,Atkinson M

doi

10.1136/gut.34.3.299

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

299-302

issue

3

eissn

0017-5749

issn

1468-3288

journal_volume

34

pub_type

杂志文章

相关文献

GUT文献大全
  • Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.

    abstract:BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.028779

    authors: Fujii S,Fujimori T,Kawamata H,Takeda J,Kitajima K,Omotehara F,Kaihara T,Kusaka T,Ichikawa K,Ohkura Y,Ono Y,Imura J,Yamaoka S,Sakamoto C,Ueda Y,Chiba T

    更新日期:2004-05-01 00:00:00

  • Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological, and ultrastructural findings.

    abstract::An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.2.137

    authors: Heilmann KL,Borchard F

    更新日期:1991-02-01 00:00:00

  • Incidence and management of malignant digestive endocrine tumours in a well defined French population.

    abstract:BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.026401

    authors: Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

    更新日期:2004-04-01 00:00:00

  • Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.

    abstract:BACKGROUND:Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2007.142778

    authors: Assi K,Mills J,Owen D,Ong C,St Arnaud R,Dedhar S,Salh B

    更新日期:2008-07-01 00:00:00

  • Radiological diagnosis of recurrent colonic carcinoma at the anastomosis.

    abstract::The barium enemas of 23 cases of end-to-end anastomosis following resection of a colonic carcinoma demonstrated that the normal anastomosis should be smooth, symmetrical, and have a regular mucosal pattern. In contrast the three patients reported with proven recurrent carcinoma at the anastomosis showed irregular asym...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.9.778

    authors: Bartram C,Hale JE

    更新日期:1970-09-01 00:00:00

  • Rectal absorption of short chain fatty acids in the absence of chloride.

    abstract::The absorption of short chain fatty acids by the human rectum in the absence of chloride has been studied using a dialysis bag technique. Absorption rates of sodium, water, and short chain fatty acids were unchanged on replacing chloride with sulphate. Final concentrations of bicarbonate were 35.4 +/- 3.4 mmol/l in th...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.20.5.400

    authors: McNeil NI,Cummings JH,James WP

    更新日期:1979-05-01 00:00:00

  • Hepatitis C virus markers in patients with acute post-transfusion hepatitis treated with interferon alfa-2b.

    abstract::This trial was undertaken to establish the long term biochemical and serological outcome of patients with acute post-transfusion hepatitis C virus infection after treatment with interferon alfa-2b. After 12 months, 12 patients (eight treated, four controls) had self limited disease and 16 patients (seven treated, nine...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.34.2_suppl.s62

    authors: Genesca J,Esteban JI,Quer J,Viladomiu LL,Gonzalez A,Esteban R,Guardia J

    更新日期:1993-01-01 00:00:00

  • Granulomatous arthritis in Crohn's disease.

    abstract::A case is described of non-necrotizing, epithelioid cell granulomatous synovitis of the ankle of a 22-year-old man with Crohn's disease. It appears to be the first published example of granulomatous arthritis in association with Crohn's disease. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.13.4.257

    authors: Lindström C,Wramsby H,Ostberg G

    更新日期:1972-04-01 00:00:00

  • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.

    abstract:BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2010.218271

    authors: Jeppesen PB,Gilroy R,Pertkiewicz M,Allard JP,Messing B,O'Keefe SJ

    更新日期:2011-07-01 00:00:00

  • Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis.

    abstract:BACKGROUND AND AIM:Accumulation and infiltration by neutrophil granulocytes is a prominent feature in the local inflammatory process in ulcerative colitis (UC). The present study was performed to evaluate human neutrophil lipocalin (HNL) as a specific neutrophil marker in the inflamed lesions of the colon and rectum in...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.50.4.501

    authors: Carlson M,Raab Y,Sevéus L,Xu S,Hällgren R,Venge P

    更新日期:2002-04-01 00:00:00

  • Genetic variation and gastric cancer risk: a field synopsis and meta-analysis.

    abstract:BACKGROUND:Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS:We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk ...

    journal_title:Gut

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/gutjnl-2015-309168

    authors: Mocellin S,Verdi D,Pooley KA,Nitti D

    更新日期:2015-08-01 00:00:00

  • Primary biliary cirrhosis presenting with granulomatous skin lesions.

    abstract::A case is described of primary biliary cirrhosis in a 59 year old woman who initially presented with a rash over her lower legs 18 months before diagnosis. Skin biopsy examination showed non-caseating granulomas of the sarcoid type. It is believed that this is the first reported case of primary biliary cirrhosis prese...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.4.564

    authors: Jardine DL,Chambers ST,Hart DJ,Chapman BA

    更新日期:1994-04-01 00:00:00

  • Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis.

    abstract:BACKGROUND:Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectal neoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.062059

    authors: Fujii S,Tominaga K,Kitajima K,Takeda J,Kusaka T,Fujita M,Ichikawa K,Tomita S,Ohkura Y,Ono Y,Imura J,Chiba T,Fujimori T

    更新日期:2005-09-01 00:00:00

  • Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe.

    abstract:OBJECTIVES:Screening colonoscopy to monitor for early colitis-associated colon cancer (CAC) is difficult due to the aberrant mucosal patterns associated with long-standing colitis. The aim of this study was to develop a rapid fluorescent detection method for use during colonoscopy for improving the detection of CAC uti...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-301795

    authors: Mitsunaga M,Kosaka N,Choyke PL,Young MR,Dextras CR,Saud SM,Colburn NH,Sakabe M,Nagano T,Asanuma D,Urano Y,Kobayashi H

    更新日期:2013-08-01 00:00:00

  • Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels.

    abstract:BACKGROUND/AIM:To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. METHODS:HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC an...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2007.119859

    authors: Yuen MF,Tanaka Y,Shinkai N,Poon RT,But DY,Fong DY,Fung J,Wong DK,Yuen JC,Mizokami M,Lai CL

    更新日期:2008-01-01 00:00:00

  • Once daily versus three times daily mesalazine granules in active ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial.

    abstract:OBJECTIVES:To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN:A randomised, double-blind, double-dummy, parallel group, multicentre, international, ph...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2008.154302

    authors: Kruis W,Kiudelis G,Rácz I,Gorelov IA,Pokrotnieks J,Horynski M,Batovsky M,Kykal J,Boehm S,Greinwald R,Mueller R,International Salofalk OD Study Group.

    更新日期:2009-02-01 00:00:00

  • Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

    abstract:OBJECTIVE:Enterochromaffin cell-derived serotonin (5-HT) promotes intestinal inflammation. We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal inflammation; moreover,...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2013-304901

    authors: Margolis KG,Stevanovic K,Li Z,Yang QM,Oravecz T,Zambrowicz B,Jhaver KG,Diacou A,Gershon MD

    更新日期:2014-06-01 00:00:00

  • Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat.

    abstract::Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91%; ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.suppl.213

    authors: Conlon JM,Bailey CJ,Flatt PR

    更新日期:1987-01-01 00:00:00

  • DNA aneuploidy in ulcerative colitis.

    abstract::The prevalence of deoxyribonucleic acid (DNA) aneuploidy in 297 samples from 38 patients with ulcerative colitis of varying duration was investigated by flow cytometry. In 12 patients colitis was complicated by the development of colorectal carcinoma: one had three synchronous carcinomas. Only four of 14 carcinomas we...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.27.12.1414

    authors: Fozard JB,Quirke P,Dixon MF,Giles GR,Bird CC

    更新日期:1986-12-01 00:00:00

  • Increased risk and case fatality rate of pyogenic liver abscess in patients with liver cirrhosis: a nationwide study in Denmark.

    abstract:BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.2.260

    authors: Mølle I,Thulstrup AM,Vilstrup H,Sørensen HT

    更新日期:2001-02-01 00:00:00

  • Endoscopic therapy of Barrett's: what more do we need to know?

    abstract::Results emerging from endoscopic treatments to ablate Barrett's oesophagus indicate that APC alone or ALA-PDT in combination with APC achieves complete clearance of Barrett's epithelium in approximately two thirds of patients. ...

    journal_title:Gut

    pub_type: 评论,杂志文章

    doi:10.1136/gut.2003.036392

    authors: Van Laethem JL,Devière J

    更新日期:2004-06-01 00:00:00

  • Jejunal manometry in distal subacute mechanical obstruction: significance of prolonged simultaneous contractions.

    abstract::The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.30.4.468

    authors: Camilleri M

    更新日期:1989-04-01 00:00:00

  • Determinants of perception of heartburn and regurgitation.

    abstract:BACKGROUND AND AIMS:It is not known why some reflux episodes evoke symptoms and others do not. We investigated the determinants of perception of gastro-oesophageal reflux. METHODS:In 32 patients with symptoms suggestive of gastro-oesophageal reflux, 24 hour ambulatory pH and impedance monitoring was performed after ce...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.074690

    authors: Bredenoord AJ,Weusten BL,Curvers WL,Timmer R,Smout AJ

    更新日期:2006-03-01 00:00:00

  • Inhibitory effect of unconjugated bile acids on the intestinal transport of 5-methyltetrahydrofolate in rat jejunum in vitro.

    abstract::The effect of the unconjugated bile acids, cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids, and of the conjugated bile acid taurocholic acid on the mucosal-to-serosal transport and tissue uptake of the naturally occurring folate derivative, 5-methyltetrahydrofolate (5-CH3H4PteGlu) was examined in ever...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.12.1376

    authors: Said HM,Hollander D,Strum WB

    更新日期:1984-12-01 00:00:00

  • Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue.

    abstract::Two peptides which are potent stimulants of gastric acid secretion are isolated from Zollinger-Ellison tumour tissue. They have aminoacid constitutions identical with those of human gastrin types I and II as isolated from human antral mucosa, and they are present in similar proportions. Their electrophoretic and chrom...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.10.8.603

    authors: Gregory RA,Tracy HJ,Agarwal KL,Grossman MI

    更新日期:1969-08-01 00:00:00

  • Comparison of magnetic resonance imaging colonography with conventional colonoscopy for the assessment of intestinal inflammation in patients with inflammatory bowel disease: a feasibility study.

    abstract:AIM:Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatory bowel disease (IBD), we compared MRI based colonography with conventional colonoscopy for assessing the presence and exte...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.037390

    authors: Schreyer AG,Rath HC,Kikinis R,Völk M,Schölmerich J,Feuerbach S,Rogler G,Seitz J,Herfarth H

    更新日期:2005-02-01 00:00:00

  • Effect of cimetidine on the human lower oesophageal sphincter.

    abstract::Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.18.2.99

    authors: Osborne DH,Lennon J,Henderson M,Lidgard G,Creel R,Carter DC

    更新日期:1977-02-01 00:00:00

  • Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.

    abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320608

    authors: Sano M,Takahashi R,Ijichi H,Ishigaki K,Yamada T,Miyabayashi K,Kimura G,Mizuno S,Kato H,Fujiwara H,Nakatsuka T,Tanaka Y,Kim J,Masugi Y,Morishita Y,Tanaka M,Ushiku T,Nakai Y,Tateishi K,Ishii Y,Isayama H,Moses HL,

    更新日期:2020-10-21 00:00:00

  • Optimum dosage of ispaghula husk in patients with irritable bowel syndrome: correlation of symptom relief with whole gut transit time and stool weight.

    abstract::To determine the optimum dose of ispaghula husk in patients with irritable bowel syndrome (IBS) and to assess the correlation, if any between the relief in patients' symptoms and the whole gut transit time, and the increase in stool weight, a two part study was carried out. In part 1, 14 male patients were given ispag...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.28.2.150

    authors: Kumar A,Kumar N,Vij JC,Sarin SK,Anand BS

    更新日期:1987-02-01 00:00:00

  • Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.

    abstract:BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.149039

    authors: Kallifatidis G,Rausch V,Baumann B,Apel A,Beckermann BM,Groth A,Mattern J,Li Z,Kolb A,Moldenhauer G,Altevogt P,Wirth T,Werner J,Schemmer P,Büchler MW,Salnikov AV,Herr I

    更新日期:2009-07-01 00:00:00