Genetic variation and gastric cancer risk: a field synopsis and meta-analysis.

abstract：BACKGROUND:Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS:To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS:Wistar rats, aged eight weeks, underwent 60% proximal resection or transection ...

journal_title：Gut

authors： Buts JP,De Keyser N,Marandi S,Hermans D,Sokal EM,Chae YH,Lambotte L,Chanteux H,Tulkens PM

更新日期：1999-07-01 00:00:00

abstract：:Clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has a similar antimicrobial spectrum to erythromycin but a better in vitro MIC90 (0.03 microgram/l-1) against Helicobacter pylori (H pylori). This study aimed at determining the eradication rate using clarithromycin 500 mg thrice daily and ome...

journal_title：Gut

authors： Logan RP,Gummett PA,Schaufelberger HD,Greaves RR,Mendelson GM,Walker MM,Thomas PH,Baron JH,Misiewicz JJ

更新日期：1994-03-01 00:00:00

abstract：:The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...

journal_title：Gut

authors： Bonino F,Colloredo Mels G,Bellati G,Ideo G,Oliveri F,Colombatto P,Brunetto MR

更新日期：1993-01-01 00:00:00

abstract：:The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted flu...

journal_title：Gut

authors： Mitchell TJ,Ketley JM,Haslam SC,Stephen J,Burdon DW,Candy DC,Daniel R

更新日期：1986-01-01 00:00:00

abstract：:Seventeen patients with proven systemic sclerosis had a peroral jejunal biopsy performed. Four biopsies were regarded as showing abnormalities, which were mostly confined to the deeper structures, although in two there was a minimal degree of villous atrophy without epithelial cell changes. Passive intestinal permeabi...

journal_title：Gut

authors： Cobden I,Rothwell J,Axon AT,Dixon MF,Lintott DJ,Rowell NR

更新日期：1980-04-01 00:00:00

abstract：:To study the mechanism for the adaptive mucosal hyperplasia which occurs independent of luminal nutrition and pancreatico-biliary secretions in isolated Thiry-Vella segments of intestine from lactating rats, and to examine the effects of prolactin on small bowel mucosal structure in the rat, we used two models of expe...

journal_title：Gut

authors： Muller E,Dowling RH

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS:To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal react...

journal_title：Gut

authors： McAlindon ME,Muller AF,Filipowicz B,Hawkey CJ

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic therapies, there is a need for cell lines that preserve the in vivo phenotype of human HSCs to elucidate pathways of human...

journal_title：Gut

authors： Xu L,Hui AY,Albanis E,Arthur MJ,O'Byrne SM,Blaner WS,Mukherjee P,Friedman SL,Eng FJ

更新日期：2005-01-01 00:00:00

abstract：:We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency. ...

journal_title：Gut

authors： Lyons DJ,Gilvarry JM,Fielding JF

更新日期：1990-07-01 00:00:00

abstract：:Three pH electrodes in clinical use were examined--(1) antimony electrode with remote reference electrode (Synectics 0011), (2) glass electrode with remote reference electrode (Microelectrodes Inc. MI 506) and (3) combined glass electrode with integral reference electrode (Radiometer GK2801C). In vitro studies showed ...

journal_title：Gut

authors： McLauchlan G,Rawlings JM,Lucas ML,McCloy RF,Crean GP,McColl KE

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2 (TREM-2) is predominantly expressed in hepatic non-parenchymal cells and i...

journal_title：Gut

authors： Esparza-Baquer A,Labiano I,Sharif O,Agirre-Lizaso A,Oakley F,Rodrigues PM,Zhuravleva E,O'Rourke CJ,Hijona E,Jimenez-Agüero R,Riaño I,Landa A,La Casta A,Zaki MYW,Munoz-Garrido P,Azkargorta M,Elortza F,Vogel A,Schabbaue

更新日期：2020-09-09 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease with the worst survival rate of common solid tumours. Preclinical models that accurately reflect the genetic and biological diversity of PDAC will be important for delineating features of tumour biology and therapeutic vulnerabilities. ...

journal_title：Gut

authors： Knudsen ES,Balaji U,Mannakee B,Vail P,Eslinger C,Moxom C,Mansour J,Witkiewicz AK

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Six to 12 months of ingestion of moderate amounts of oats does not have a harmful effect in adult patients with coeliac disease. As the safety of long term intake of oats in coeliac patients is not known, we continued our previous 6-12 month study for five years. AIM:To assess the safety of long term ingest...

journal_title：Gut

authors： Janatuinen EK,Kemppainen TA,Julkunen RJ,Kosma VM,Mäki M,Heikkinen M,Uusitupa MI

更新日期：2002-03-01 00:00:00

abstract：:Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetica...

journal_title：Gut

authors： Morgan MY,Reshef R,Shah RR,Oates NS,Smith RL,Sherlock S

更新日期：1984-10-01 00:00:00

abstract：:The feasibility of surgery in amoebic colitis is presented by illustrative case histories in two patients. Subtotal colectomy and ileostomy were carried out for fulminating colitis in the one and exteriorization, excision, and subsequent re-anastomosis of a localized perforated area of bowel in the other. It is sugges...

journal_title：Gut

authors： Stein D,Bank S

更新日期：1970-11-01 00:00:00

abstract：:It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptor...

journal_title：Gut

authors： Shahidullah M,Kennedy TL,Parks TG

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken...

journal_title：Gut

authors： Sonoda H,Kohnoe S,Yamazato T,Satoh Y,Morizono G,Shikata K,Morita M,Watanabe A,Morita M,Kakeji Y,Inoue F,Maehara Y

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To compare performance measures across all three rounds of the English bowel cancer screening faecal occult blood test pilot and their relation to social deprivation and ethnicity. METHODS:In each round in three primary care trusts, data for a restricted population of over 48,500 aged 60-69 years were analy...

journal_title：Gut

authors： Moss SM,Campbell C,Melia J,Coleman D,Smith S,Parker R,Ramsell P,Patnick J,Weller DP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The 13C-Hiolein breath test (98% [U-13C] labelled long chain triglyceride mixture (highly labelled triolein) was evaluated as a non-invasive, non-radioactive test for exocrine pancreatic insufficiency. Accuracy and clinical validity were examined with reference to both the secretin pancreozymin test...

journal_title：Gut

authors： Lembcke B,Braden B,Caspary WF

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Faecal concentrations of the protein calprotectin have been found to be elevated in patients with colorectal neoplasia, suggesting that it might be used as a screening tool for colorectal cancer as well as adenomas. AIMS:To measure the sensitivity and specificity of faecal calprotectin for the detection of ...

journal_title：Gut

authors： Kronborg O,Ugstad M,Fuglerud P,Johne B,Hardcastle J,Scholefield JH,Vellacott K,Moshakis V,Reynolds JR

更新日期：2000-06-01 00:00:00

abstract：:The spectrum of clinical disease associated with specific defects in jejunal brush border membrane sodium/proton exchange is poorly defined and only two patients have been described so far. Jejunal brush border membrane transport studies were performed in a boy who presented with lethal familial protracted diarrhoea i...

journal_title：Gut

authors： Keller KM,Wirth S,Baumann W,Sule D,Booth IW

更新日期：1990-10-01 00:00:00

abstract：:Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...

journal_title：Gut

authors： Logan RF,Gillon J,Ferrington C,Ferguson A

更新日期：1981-05-01 00:00:00

abstract：:This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of diffe...

journal_title：Gut

authors： Williams R

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Eradication of Barrett's mucosa by thermal or photoablation combined with high doses of proton pump inhibitors is a potentially attractive strategy in the management of this preneoplastic condition. However, major concerns of this method are the persistence of residual metaplastic glands beneath the new squa...

journal_title：Gut

authors： Van Laethem JL,Peny MO,Salmon I,Cremer M,Devière J

更新日期：2000-04-01 00:00:00

abstract：:Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...

journal_title：Gut

authors： Altomare D,Pilot MA,Scott M,Williams N,Rubino M,Ilincic L,Waldron D

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonoscopic surveillance for cancer in longstanding extensive ulcerative colitis relies heavily on non-targeted mucosal biopsies. Chromoendoscopy can aid detection of subtle mucosal abnormalities. We hypothesised that routine pancolonic indigo carmine dye spraying would improve the macroscopic dete...

journal_title：Gut

authors： Rutter MD,Saunders BP,Schofield G,Forbes A,Price AB,Talbot IC

更新日期：2004-02-01 00:00:00

abstract：:We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

journal_title：Gut

authors： McGuinness EE,Morgan RG,Wormsley KG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...

journal_title：Gut

authors： Kim J,Reber HA,Dry SM,Elashoff D,Chen SL,Umetani N,Kitago M,Hines OJ,Kazanjian KK,Hiramatsu S,Bilchik AJ,Yong S,Shoup M,Hoon DS

更新日期：2006-11-01 00:00:00

abstract：:In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...

journal_title：Gut

authors： Zargar SA,Khuroo MS,Mahajan R,Jan GM,Dewani K,Koul V

更新日期：1991-07-01 00:00:00

abstract：:Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...

journal_title：Gut

authors： Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

更新日期：1993-04-01 00:00:00