Abstract:
:The spectrum of clinical disease associated with specific defects in jejunal brush border membrane sodium/proton exchange is poorly defined and only two patients have been described so far. Jejunal brush border membrane transport studies were performed in a boy who presented with lethal familial protracted diarrhoea in the first few days of life. Using jejunal brush border membrane vesicles prepared from conventional jejunal biopsy specimens, initial sodium uptake under H+ gradient conditions was found to be only 6% of the mean control value. In contrast, sodium stimulated glucose uptake was normal. Our data confirm the importance of a congenital defect in this exchanger as a cause of severe sodium-losing diarrhoea and extend the spectrum of disorders characterised by a specific defect in brush border membrane Na+/H+ exchange to include some forms of lethal familial protracted diarrhoea.
journal_name
Gutjournal_title
Gutauthors
Keller KM,Wirth S,Baumann W,Sule D,Booth IWdoi
10.1136/gut.31.10.1156subject
Has Abstractpub_date
1990-10-01 00:00:00pages
1156-8issue
10eissn
0017-5749issn
1468-3288journal_volume
31pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.026401
更新日期:2004-04-01 00:00:00
abstract::The carrier rate of hepatitis B virus (HBV) in black Africans averages 10.4% throughout the continent. Even within each country, however, there may be wide variations. HBV carriage in black Africans is largely established in early childhood, mostly through horizontal transmission. Perinatal transmission also occurs bu...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.38.suppl_2.s31
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with diseas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.3.434
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver inflammation and liver failure, the regulation of hepatic cell death causing AIH remains poorly understood. The aim of t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311247
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of tumours and was proposed to be oncogenic, but high GATA6 levels are found in well-differentiated tumou...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311256
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar metaplasia of the distal oesophagus. METHODS:We used the squamocol...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308914
更新日期:2015-11-01 00:00:00
abstract::Pathogenic E coli have adhesive properties which are mirrored by an increase in their surface hydrophobicity. E coli isolated from patients with ulcerative colitis possess a mannose resistant adhesin similar to that found in pathogenic E coli. In this study 42 E coli isolates from patients with colitis have been compa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.1.41
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term eff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304370
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. This is illustrated by the non-neoplastic gastric-type heteroplasias present at birth in the pericaecal region of Cdx2(+/-) mice. Furthermore...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.10.1465
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321609
更新日期:2020-12-17 00:00:00
abstract:OBJECTIVE:Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. The aim of the present study was to explore whether CTRC mutants indu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.198903
更新日期:2010-03-01 00:00:00
abstract::We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.207
更新日期:1987-01-01 00:00:00
abstract::An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.2.137
更新日期:1991-02-01 00:00:00
abstract::Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorpti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.6.480
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:The detection of hepatocellular cancers (HCC) is a major role of preoperative imaging in patients with end stage liver disease being considered for orthotopic liver transplantation (OLT). AIMS:To assess the sensitivity of iodised oil computed tomography (IOCT). PATIENTS AND METHODS:A prospective evaluation...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.3.404
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2006.109157
更新日期:2007-06-01 00:00:00
abstract::Amino acid induced acid and gastrin responses during intragastric titration at pH 2.5 and 5.5 were compared in normal subjects and duodenal ulcer patients with G-cell hyperfunction. The latter were identified on the basis of raised basal or maximal acid outputs and increased gastrin responses to feeding. In normal sub...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.3.232
更新日期:1985-03-01 00:00:00
abstract::The thoracic duct was cannulated in six patients who were actively bleeding from varices and had not responded to conservative treatment but draining lymph from the thoracic duct did not control bleeding in five patients. There was no drop in intrasplenic pulp pressure following this procedure when recorded in three o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.1.48
更新日期:1971-01-01 00:00:00
abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311224
更新日期:2017-03-01 00:00:00
abstract::In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms s...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.8.1042
更新日期:1993-08-01 00:00:00
abstract::The injection of rabbits' ileum with homogenates of both normal and Crohn's affected human bowel tissue gave Crohn's-like changes in 11 of 27 animals after six months, but 12 months after injection the rabbit bowel had reverted to normal. The addition of ampicillin to the homogenates prevented the appearance of these ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.5.360
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.028779
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC). DESIGN:We conducted a prospective cohort study of 83 147 participants (age range: 45-79 years) enrolled in the Cohort of Swedish Men and Swedish Mammography Cohort. A validated food...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319505
更新日期:2020-09-01 00:00:00
abstract::Inflammatory fibroid polyps are uncommon but well documented as solitary polyps occurring typically in the stomach or ileum. A Devon family has previously been reported in which a female in three successive generations has presented with multiple polyps requiring repeated surgery over a number of years. A further two ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.7.1004
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Both bile salts and glutathione participate in the generation of canalicular bile flow. In this work, we have investigated the effect of different bile salts on hepatic glutathione metabolism. METHODS:Using the isolated and perfused rat liver, we studied hepatic glutathione content, and metabolism ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.5.701
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum of genomic alterations and identified recurrent mutations in the ErbB pathway in GBC. Here, we aime...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316039
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.143271
更新日期:2008-08-01 00:00:00
abstract::We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.4.326
更新日期:1982-04-01 00:00:00
abstract::Eighteen patients with achalasia of the cardia diagnosed by radiography, endoscopy, and manometry were subjected to forced pneumatic dilatation under fluoroscopic control. The procedure was uneventful in all but one patient who developed a pneumomediastinum which resolved on conservative management. A satisfactory res...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.6.541
更新日期:1982-06-01 00:00:00
abstract::Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.8.824
更新日期:1984-08-01 00:00:00