Intestinal perfusion studies in tropical sprue. 2. Movement of water and electrolytes.

abstract：:Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...

journal_title：Gut

authors： Logan RF,Gillon J,Ferrington C,Ferguson A

更新日期：1981-05-01 00:00:00

abstract：:The HGT-1 gastric cancer cell line was used to determine the actions of protein kinase C on the stimulation of adenylate cyclase by the human histamine H2 receptor, and the receptors for gastric inhibitory polypeptide and truncated glucagon like peptide 1 (TGLP-1). Suspensions of HGT-1 cells were preincubated with the...

journal_title：Gut

authors： McKenna P,Williams JM,Gespach CP,Hanson PJ

更新日期：1993-07-01 00:00:00

abstract：:A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed...

journal_title：Gut

authors： Thesleff P,Benoni C,Mårtensson H,Nilsson A,Sundler F,Akesson B

更新日期：1987-10-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS:To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal react...

journal_title：Gut

authors： McAlindon ME,Muller AF,Filipowicz B,Hawkey CJ

更新日期：1996-04-01 00:00:00

abstract：:Twenty-four patients who experienced 26 attacks of acute pancreatitis were studied. Endotoxaemia, as measured by the limulus lysate assay, was present in 13 of the attacks. Six out of seven patients with systemic complications of the disease had endotoxaemia. C3 catabolism was increased in all 26 attacks of pancreatit...

journal_title：Gut

authors： Foulis AK,Murray WR,Galloway D,McCartney AC,Lang E,Veitch J,Whaley K

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there is paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, interventions including endoscopy, radiology and surgery as well as clinical outcomes....

journal_title：Gut

authors： Oakland K,Guy R,Uberoi R,Hogg R,Mortensen N,Murphy MF,Jairath V,UK Lower GI Bleeding Collaborative.

更新日期：2018-04-01 00:00:00

abstract：:The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...

journal_title：Gut

authors： al Mardini H,al Jumaili B,Record CO,Burke D

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Crohn's disease (CD) ileal lesions are colonised by pathogenic adherent-invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. In addition, increased expression of endoplasmic reticulum (ER)-localised stress response proteins, due...

journal_title：Gut

authors： Rolhion N,Barnich N,Bringer MA,Glasser AL,Ranc J,Hébuterne X,Hofman P,Darfeuille-Michaud A

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM:To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS:Apple extracts were obtained from freeze drie...

journal_title：Gut

authors： Graziani G,D'Argenio G,Tuccillo C,Loguercio C,Ritieni A,Morisco F,Del Vecchio Blanco C,Fogliano V,Romano M

更新日期：2005-02-01 00:00:00

abstract：:Serum zinc concentrations and urine zinc excretion have been studied in 10 patients with severe Crohn's disease before and during 59 patient-weeks of intravenous nutrition. Before serum zinc concentrations (9.9 +/- 1.0 mumol/l: mean +/- SEM) and urine zinc excretion (3-3 +/- 0.6 mumol/24h) were less than controls (p l...

journal_title：Gut

authors： Main AN,Hall MJ,Russell RI,Fell GS,Mills PR,Shenkin A

更新日期：1982-11-01 00:00:00

abstract：:It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptor...

journal_title：Gut

authors： Shahidullah M,Kennedy TL,Parks TG

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The liver represents one of the major sites of human glucuronidation. Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to the formation of usually inactive glucuronides. Hepatic glucuronidation undergoes significant changes during fetal and neonatal development re...

journal_title：Gut

authors： Strassburg CP,Strassburg A,Kneip S,Barut A,Tukey RH,Rodeck B,Manns MP

更新日期：2002-02-01 00:00:00

abstract：:Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and derma...

journal_title：Gut

authors： Duggan JM,Dobson AJ,Johnson H,Fahey P

更新日期：1986-08-01 00:00:00

abstract：:Intestinal adaptation (small intestinal weight and length, weight of the caecum and of the residual colon) to feeding different doses (0-5-50-500 mg/kg bw) of the absorbable, competitive alpha-glucosidase inhibitors BAY m 1099 and BAY o 1248 for three, seven, or 28 days was studied in rats. With the highest dose of ei...

journal_title：Gut

authors： Lembcke B,Löser C,Fölsch UR,Wöhler J,Creutzfeldt W

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...

journal_title：Gut

authors： Schoon EJ,Müller MC,Vermeer C,Schurgers LJ,Brummer RJ,Stockbrügger RW

更新日期：2001-04-01 00:00:00

abstract：:Rosetting techniques were used to estimate T and B cell subpopulations in the peripheral blood in patients with treated and untreated adult coeliac disease and in control subjects. In patients with untreated coeliac disease, T cell numbers were significantly lower than in controls or treated patients, although there w...

journal_title：Gut

authors： Bullen AW,Losowsky MS

更新日期：1978-10-01 00:00:00

abstract：OBJECTIVE:Tumour-associated macrophages (TAMs) play key roles in tumour progression. Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies, raising the prospect of their targeting in human cancer. DESIGN:In a large retrospective cohort study involving 110 patients with pancreatic ...

journal_title：Gut

authors： Di Caro G,Cortese N,Castino GF,Grizzi F,Gavazzi F,Ridolfi C,Capretti G,Mineri R,Todoric J,Zerbi A,Allavena P,Mantovani A,Marchesi F

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics, complicating the design of clinical trials and biomarker developments. We analysed 1048 oesophageal tumour-germline pairs from both subtypes, to chara...

journal_title：Gut

authors： Lin DC,Dinh HQ,Xie JJ,Mayakonda A,Silva TC,Jiang YY,Ding LW,He JZ,Xu XE,Hao JJ,Wang MR,Li C,Xu LY,Li EM,Berman BP,Phillip Koeffler H

更新日期：2018-10-01 00:00:00

abstract：:The spectrum of clinical disease associated with specific defects in jejunal brush border membrane sodium/proton exchange is poorly defined and only two patients have been described so far. Jejunal brush border membrane transport studies were performed in a boy who presented with lethal familial protracted diarrhoea i...

journal_title：Gut

authors： Keller KM,Wirth S,Baumann W,Sule D,Booth IW

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylori infection and gastric atrophy status. SUBJECTS AND METHODS:A total of 9293 participants in a mass health appraisa...

journal_title：Gut

authors： Watabe H,Mitsushima T,Yamaji Y,Okamoto M,Wada R,Kokubo T,Doi H,Yoshida H,Kawabe T,Omata M

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:The normal intestinal microflora plays an important role in host metabolism and provides a natural defence mechanism against invading pathogens. Although the microbiota in adults has been extensively studied, little is known of the changes that occur in the microflora with aging. These may have important con...

journal_title：Gut

authors： Hopkins MJ,Sharp R,Macfarlane GT

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Linkage data have now identified several inflammatory bowel disease (IBD) susceptibility loci but these data have not been consistently replicated in independent studies. One potential explanation for this is the possibility that patients enrolled in such studies may have been erroneously classified with res...

journal_title：Gut

authors： Silverberg MS,Daly MJ,Moskovitz DN,Rioux JD,McLeod RS,Cohen Z,Greenberg GR,Hudson TJ,Siminovitch KA,Steinhart AH

更新日期：2001-12-01 00:00:00

abstract：:Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

journal_title：Gut

authors： Moran AP,Gupta A,Joshi L

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to protect against the development of colon cancer. However, the mechanism(s) by which NSAIDs exert their effects is not clear. AIMS:The aim of this study was to examine the effects of NSAIDs on mRNA expression of tumour suppressor adenomatou...

journal_title：Gut

authors： Kishimoto Y,Takata N,Jinnai T,Morisawa T,Shiota G,Kawasaki H,Hasegawa J

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to elucidate further the mechanisms ...

journal_title：Gut

authors： Paterson WG,Miller DV,Dilworth N,Assini JB,Lourenssen S,Blennerhassett MG

更新日期：2007-10-01 00:00:00

abstract：:We have determined the relative importance of day and night time gastric acid inhibition for duodenal ulcer healing by comparing the anti-ulcer efficacy of a single morning with that of a single bedtime dose of ranitidine. One hundred and thirty patients with active duodenal ulcer were randomly assigned to a double-bl...

journal_title：Gut

authors： Bianchi Porro G,Parente F,Sangaletti O

更新日期：1990-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to...

journal_title：Gut

authors： Negro F

更新日期：2010-09-01 00:00:00

abstract：:The responses to deglutition of the lower oesophageal high pressure zone were studied in 13 healthy subjects. The recording assembly included three perfused pressure recording catheters, whose recording orifices were at the same axial level, and a more distally situated pH electrode. Relaxation and contraction progres...

journal_title：Gut

authors： Kaye MD,Showalter JP

更新日期：1972-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...

journal_title：Gut

authors： Houghton LA,Calvert EL,Jackson NA,Cooper P,Whorwell PJ

更新日期：2002-11-01 00:00:00