Inhibition of nocturnal acidity is important but not essential for duodenal ulcer healing.

abstract：:Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on ...

journal_title：Gut

authors： Fraser AG,Lam WM,Luk YW,Sercombe J,Sawyerr AM,Hudson M,Samloff IM,Pounder RE

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal adenocarcinoma cancer (PDAC). DESIGN:We screened 429 kinase inhibitors for ...

journal_title：Gut

authors： Huang J,Chen P,Liu K,Liu J,Zhou B,Wu R,Peng Q,Liu ZX,Li C,Kroemer G,Lotze M,Zeh H,Kang R,Tang D

更新日期：2020-08-14 00:00:00

abstract：:Polyacrylamide gel electrophoresis of pure pancreatic juice from 14 healthy normal subjects, 11 chronic alcoholics without detectable pancreatic disease, 15 patients with pancreatitis, and two with cancer of the pancreas consistently demonstrated the presence of two variants of trypsinogen with different electrophoret...

journal_title：Gut

authors： Rinderknecht H,Renner IG,Carmack C

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

journal_title：Gut

authors： de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Osteoporosis and fractures are frequently encountered in patients with Crohn's disease. In order to prevent fractures, treatment with bone protecting drugs appears warranted early in the course of bone disease when bone loss is not yet prominent. We therefore aimed to demonstrate a beneficial effect on bone d...

journal_title：Gut

authors： van Bodegraven AA,Bravenboer N,Witte BI,Dijkstra G,van der Woude CJ,Stokkers PC,Russel MG,Oldenburg B,Pierik M,Roos JC,van Hogezand RA,Dik VK,Oostlander AE,Netelenbos JC,van de Langerijt L,Hommes DW,Lips P,Dutch Initiat

更新日期：2014-09-01 00:00:00

abstract：:Bile acid pool size and kinetics were determined in 17 patients with cirrhosis and 11 patients without liver disease and correlated with the severity of liver disease as determined by the usual clinical and laboratory criteria. In order to assess the severity of liver disease, a grading system was devised which assign...

journal_title：Gut

authors： McCormick WC 3rd,Bell CC Jr,Swell L,Vlahcevic ZR

更新日期：1973-11-01 00:00:00

abstract：:Twenty-four patients who experienced 26 attacks of acute pancreatitis were studied. Endotoxaemia, as measured by the limulus lysate assay, was present in 13 of the attacks. Six out of seven patients with systemic complications of the disease had endotoxaemia. C3 catabolism was increased in all 26 attacks of pancreatit...

journal_title：Gut

authors： Foulis AK,Murray WR,Galloway D,McCartney AC,Lang E,Veitch J,Whaley K

更新日期：1982-08-01 00:00:00

abstract：:To test the hypothesis that Helicobacter pylori infection is associated with a decreased intragastric acidity during omeprazole therapy, ambulatory 24 hour dual point gastric pH recordings were performed in 18 H pylori positive and 14 H pylori negative subjects. There was a four to six week washout period between the ...

journal_title：Gut

authors： Verdú EF,Armstrong D,Fraser R,Viani F,Idström JP,Cederberg C,Blum AL

更新日期：1995-04-01 00:00:00

abstract：:The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal ...

journal_title：Gut

authors： Shorrock CJ,Rees WD

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins. Recent studies indicate that both may be deficient in Crohn's disease. To elucidate the possible functional c...

journal_title：Gut

authors： Nuding S,Fellermann K,Wehkamp J,Stange EF

更新日期：2007-09-01 00:00:00

abstract：:Pregnancy and contraceptive steroids are associated with a raised incidence of cholesterol gall stone disease. In pregnancy there is an increase in the size of the gall bladder. Investigation of hepatobiliary function in man and mammals has not established if the enlarged gall bladder is simply dilated, or if the abso...

journal_title：Gut

authors： Rådberg G,Svanvik J

更新日期：1986-01-01 00:00:00

abstract：AIM:The aim of this study was to implement an imaging protocol for positron emission tomography/computed tomography (PET/CT) colonography and to combine this protocol with whole body PET/CT tumour staging for a single whole body examination for routine clinical use. SUBJECTS AND METHODS:A whole body PET/CT protocol fo...

journal_title：Gut

authors： Veit P,Kühle C,Beyer T,Kuehl H,Herborn CU,Börsch G,Stergar H,Barkhausen J,Bockisch A,Antoch G

更新日期：2006-01-01 00:00:00

abstract：:The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...

journal_title：Gut

authors： Spence RW,Burns-Cox CJ

更新日期：1975-06-01 00:00:00

abstract：:Thirty eight patients with Crohn's disease and 30 patients with ulcerative colitis have been assessed using the technique of faecal excretion of 111Indium granulocytes to quantify precisely acute inflammatory activity. At the time of each faecal granulocyte measurement the serum concentration of the acute phase protei...

journal_title：Gut

authors： Saverymuttu SH,Hodgson HJ,Chadwick VS,Pepys MB

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Intestinal allograft rejection resembles Crohn's disease clinically and pathologically. An understanding of its mechanism could impact this life-saving procedure, as well as provide insight into the pathophysiology of inflammatory bowel disease. The NOD2 protein has been implicated as a key player in intesti...

journal_title：Gut

authors： Fishbein T,Novitskiy G,Mishra L,Matsumoto C,Kaufman S,Goyal S,Shetty K,Johnson L,Lu A,Wang A,Hu F,Kallakury B,Lough D,Zasloff M

更新日期：2008-03-01 00:00:00

abstract：:A series of experiments has been performed in healthy male volunteers to investigate the disposition of orally administered disodium azodisalicylate, a potentially useful drug for the treatment of ulcerative colitis. The drug was given by mouth in doses of up to 2 g a day for six weeks and there were no adverse effect...

journal_title：Gut

authors： Willoughby CP,Aronson JK,Agback H,Bodin NO,Truelove SC

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The gastrointestinal microflora exerts a barrier effect against enteropathogens. The aim of this study was to examine if bifidobacteria, a major species of the human colonic microflora, participates in the barrier effect by developing antimicrobial activity against enterovirulent bacteria. METHODS:...

journal_title：Gut

authors： Liévin V,Peiffer I,Hudault S,Rochat F,Brassart D,Neeser JR,Servin AL

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Activated hepatic stellate cells (HSCs) are an attractive target for antifibrotic therapy based on their key role in extracellular matrix accumulation during liver injury. AIM:: To develop a system for regulable and cell-specific gene expression in HSCs to enable targeted delivery of therapeutic genes. MET...

journal_title：Gut

authors： Kinoshita K,Iimuro Y,Fujimoto J,Inagaki Y,Namikawa K,Kiyama H,Nakajima Y,Otogawa K,Kawada N,Friedman SL,Ikeda K

更新日期：2007-03-01 00:00:00

abstract：:Daytime intragastric pH, fasting and meal stimulated serum gastrin and nocturnal acid output were studied in eight male duodenal ulcer patients before, during and two days after completing nizatidine 300 mg nocte (20:00 h) for four weeks. Median nocturnal acid output (mmol/10 h) decreased during treatment to 11.6 (ran...

journal_title：Gut

authors： Fullarton GM,McLauchlan G,Macdonald A,Crean GP,McColl KE

更新日期：1989-04-01 00:00:00

abstract：:A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...

journal_title：Gut

authors： Carré IJ,Froggatt P

更新日期：1970-01-01 00:00:00

abstract：:Intestinal protein loss in chronic inflammatory bowel diseases may be easily determined by measurement of alpha-1-antitrypsin (alpha 1-AT) stool concentration and alpha 1-AT clearance. Both parameters were significantly raised in 36 and 34 patients respectively with chronic inflammatory bowel diseases, compared with e...

journal_title：Gut

authors： Fischbach W,Becker W,Mössner J,Koch W,Reiners C

更新日期：1987-04-01 00:00:00

abstract：:To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and potent histamine H2 antagonist loxtidine for five months. The trophic ef...

journal_title：Gut

authors： Brenna E,Swarts HG,Klaassen CH,de Pont JJ,Waldum HL

更新日期：1994-11-01 00:00:00

abstract：:The possible relationship between enteroglucagon and cellular proliferation in a rat model of intestinal adaptation after suppression and stimulation of enteroglucagon by somatostatin and bombesin has been investigated. Forty eight rats were divided into three groups of 16 animals, each group being further sub-divided...

journal_title：Gut

authors： Sagor GR,Ghatei MA,O'Shaughnessy DJ,Al-Mukhtar MY,Wright NA,Bloom SR

更新日期：1985-01-01 00:00:00

abstract：:Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute ...

journal_title：Gut

authors： Hobsley M,Silen W

更新日期：1969-10-01 00:00:00

abstract：:The HGT-1 gastric cancer cell line was used to determine the actions of protein kinase C on the stimulation of adenylate cyclase by the human histamine H2 receptor, and the receptors for gastric inhibitory polypeptide and truncated glucagon like peptide 1 (TGLP-1). Suspensions of HGT-1 cells were preincubated with the...

journal_title：Gut

authors： McKenna P,Williams JM,Gespach CP,Hanson PJ

更新日期：1993-07-01 00:00:00

abstract：:The plasma clearance and the liver uptake of intravenously administered (64)Cu were significantly impaired in four patients with Wilson's disease. These defects were unlikely to be simply expressions of the high liver copper concentration as the plasma clearance and hepatic uptake of (64)Cu were normal in four patient...

journal_title：Gut

authors： Smallwood RA,McIlveen B,Rosenoer VM,Sherlock S

更新日期：1971-02-01 00:00:00

abstract：:This third section of the European Crohn's and Colitis Organisation (ECCO) Consensus on the management of Crohn's disease concerns postoperative recurrence, fistulating disease, paediatrics, pregnancy, psychosomatics, extraintestinal manifestations, and alternative therapy. The first section on definitions and diagnos...

journal_title：Gut

authors： Caprilli R,Gassull MA,Escher JC,Moser G,Munkholm P,Forbes A,Hommes DW,Lochs H,Angelucci E,Cocco A,Vucelic B,Hildebrand H,Kolacek S,Riis L,Lukas M,de Franchis R,Hamilton M,Jantschek G,Michetti P,O'Morain C,Anwar MM

更新日期：2006-03-01 00:00:00

abstract：:A study of HLA-DR antigen in 75 patients with primary biliary cirrhosis has been carried out in order to test the hypothesis that genetic factors related to genes controlling immune responses might be important in the pathogenesis of primary biliary cirrhosis. The frequencies of HLA-DR locus antigens was not significa...

journal_title：Gut

authors： Bassendine MF,Dewar PJ,James OF

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer is the second most common cause of cancer death in Europe and North America. Alarm features are used to prioritize access to urgent investigation, but there is little information concerning their utility in the diagnosis of colorectal cancer. METHODS:A systematic review and meta-analysis of...

journal_title：Gut

authors： Ford AC,Veldhuyzen van Zanten SJ,Rodgers CC,Talley NJ,Vakil NB,Moayyedi P

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS:To evaluate wh...

journal_title：Gut

authors： Korponay-Szabó IR,Laurila K,Szondy Z,Halttunen T,Szalai Z,Dahlbom I,Rantala I,Kovács JB,Fésüs L,Mäki M

更新日期：2003-02-01 00:00:00