HLA-DR antigens in primary biliary cirrhosis: lack of association.

abstract：BACKGROUND:Targeting tumour necrosis factor alpha (TNF-alpha) has demonstrated efficacy in Crohn's disease. AIM:To evaluate CDP571, a humanised antibody to TNF-alpha, for treating active Crohn's disease. PATIENTS:A total of 396 patients with moderate to severe Crohn's disease. METHODS:In a 28 week, randomised, doubl...

journal_title：Gut

authors： Sandborn WJ,Feagan BG,Radford-Smith G,Kovacs A,Enns R,Innes A,Patel J

更新日期：2004-10-01 00:00:00

abstract：:It has been demonstrated that cardiac output and pulmonary, gastroduodenal, pancreatic, and splenic blood flow increases after portacaval shunt operations. This report concerns a study of cerebral haemodynamics and metabolism in eight patients with cirrhosis of the liver, examined both before and after portacaval surg...

journal_title：Gut

authors： Bianchi Porro G,Maiolo AT,Della Porta P

更新日期：1969-11-01 00:00:00

abstract：:Electrogenic (Cl-) secretion was measured as the short circuit current (Isc, microA/cm2) across muscle-stripped sheets of jejunum and ileum incubated in vitro after removal from fed rats, rats starved for three days, and chronically undernourished rats (50% of fed control intake for 21 days). Concentration and Isc res...

journal_title：Gut

authors： Nzegwu HC,Levin RJ

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Interleukin-6 (IL-6) is a well-recognised mediator of liver disease and regeneration. However, the in vivo effects of IL-6 on enterocytes and the intestinal tract have not been elucidated. We sought to determine the in vivo effects of IL-6 on enterocytes. METHODS:Murine models of increased or absen...

journal_title：Gut

authors： Jin X,Zimmers TA,Zhang Z,Pierce RH,Koniaris LG

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....

journal_title：Gut

authors： Nieuwenburg SAV,Vuik FER,Kruip MJHA,Kuipers EJ,Spaander MCW

更新日期：2019-05-01 00:00:00

abstract：:Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury. ...

journal_title：Gut

authors： Gionchetti P,Lammers KM,Rizzello F,Campieri M

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...

journal_title：Gut

authors： Schoon EJ,Müller MC,Vermeer C,Schurgers LJ,Brummer RJ,Stockbrügger RW

更新日期：2001-04-01 00:00:00

abstract：:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...

journal_title：Gut

authors： Caldara R,Barbieri C,Piepoli V,Borzio M,Masci E

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:Novel imaging methods based on specific molecular targets to detect both established neoplasms and their precursor lesions are highly desirable in cancer medicine. Previously, we identified claudin-4, an integral constituent of tight junctions, as highly expressed in various gastrointestinal tumours includin...

journal_title：Gut

authors： Neesse A,Hahnenkamp A,Griesmann H,Buchholz M,Hahn SA,Maghnouj A,Fendrich V,Ring J,Sipos B,Tuveson DA,Bremer C,Gress TM,Michl P

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Most direct understanding of enteric nerve (patho)physiology has been obtained by electrode and imaging techniques in animal models and human surgical samples. Until now, neuronal activity recordings from a more accessible human tissue source have remained a true challenge. OBJECTIVES:To record nerve activi...

journal_title：Gut

authors： Cirillo C,Tack J,Vanden Berghe P

更新日期：2013-02-01 00:00:00

abstract：:The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulc...

journal_title：Gut

authors： Hossenbocus A,Fitzpatrick P,Colin-Jones DG

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Multiorgan failure is a severe life threatening state where present therapeutic approaches are suboptimal. Epidermal growth factor (EGF) is a potent stimulant of repair in in vitro and in vivo models. We therefore examined its potential beneficial effect in reducing mortality and injury induced by the noxiou...

journal_title：Gut

authors： Caballero ME,Berlanga J,Ramirez D,Lopez-Saura P,Gozalez R,Floyd DN,Marchbank T,Playford RJ

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...

journal_title：Gut

authors： Jeppesen PB,Gilroy R,Pertkiewicz M,Allard JP,Messing B,O'Keefe SJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...

journal_title：Gut

authors： Fujii S,Fujimori T,Kawamata H,Takeda J,Kitajima K,Omotehara F,Kaihara T,Kusaka T,Ichikawa K,Ohkura Y,Ono Y,Imura J,Yamaoka S,Sakamoto C,Ueda Y,Chiba T

更新日期：2004-05-01 00:00:00

abstract：:The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine. In healthy subjects, the oxyntic, antral and duodenal muco...

journal_title：Gut

authors： Konturek SJ,Obtulowicz W,Sito E,Oleksy J,Wilkon S,Kiec-Dembinska A

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:A decrease in arterial isoleucine values after intragastric blood administration in pigs has been observed. This contrasted with increased values of most other amino acids, ammonia, and urea. After an isonitrogenous control meal in these pigs all amino acids including isoleucine increased, and urea increased...

journal_title：Gut

authors： Dejong CH,Meijerink WJ,van Berlo CL,Deutz NE,Soeters PB

更新日期：1996-07-01 00:00:00

abstract：:Previous studies have suggested that profound inhibition of gastric acid secretion may increase exposure to potentially carcinogenic N-nitroso compounds. The aim of this study was to find out if the proton pump inhibitor omeprazole (20 mg daily) is associated with increased concentrations of potentially carcinogenic N...

journal_title：Gut

authors： Verdu E,Viani F,Armstrong D,Fraser R,Siegrist HH,Pignatelli B,Idström JP,Cederberg C,Blum AL,Fried M

更新日期：1994-04-01 00:00:00

abstract：:A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisti...

journal_title：Gut

authors： Te HS,Koukoulis G,Ganger DR

更新日期：1997-08-01 00:00:00

abstract：:Rats were subjects to right hemicolectomy (including removal of the caecum), left hemicolectomy or subtotal colectomy. Body weight resumed and maintained a rate of increase very similar to that in control rats. After hemicolectomy, food intake showed no change. Faecal weight increased by about one-third after right he...

journal_title：Gut

authors： Masesa PC,Forrester JM

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...

journal_title：Gut

authors： Hofmann C,Dunger N,Grunwald N,Hämmerling GJ,Hoffmann P,Schölmerich J,Falk W,Obermeier F

更新日期：2010-10-01 00:00:00

abstract：:The effect of the unconjugated bile acids, cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids, and of the conjugated bile acid taurocholic acid on the mucosal-to-serosal transport and tissue uptake of the naturally occurring folate derivative, 5-methyltetrahydrofolate (5-CH3H4PteGlu) was examined in ever...

journal_title：Gut

authors： Said HM,Hollander D,Strum WB

更新日期：1984-12-01 00:00:00

abstract：:We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

journal_title：Gut

authors： McGuinness EE,Morgan RG,Wormsley KG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Surgery in patients with malignant bile duct obstruction is associated with high postoperative morbidity and mortality. Tumour necrosis factor alpha (TNF-alpha) plays a key role in the pathogenesis of these complications. AIMS:To determine the effect of biliary drainage on plasma concentrations of TNF-alpha...

journal_title：Gut

authors： Ballinger AB,Woolley JA,Ahmed M,Mulcahy H,Alstead EM,Landon J,Clark ML,Farthing MJ

更新日期：1998-04-01 00:00:00

abstract：:Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neop...

journal_title：Gut

authors： Lynch DA,Mapstone NP,Clarke AM,Sobala GM,Jackson P,Morrison L,Dixon MF,Quirke P,Axon AT

更新日期：1995-03-01 00:00:00

abstract：CLINICAL PRESENTATION:A 28-year-old woman presented with a 3-year history of chronic watery diarrhoea along with abdominal pain and bloating, which could mostly be alleviated after defecation. Her symptom of diarrhoea, at least three times a day, could be relieved by neither probiotics nor antidiarrhoeal agents. She ha...

journal_title：Gut

authors： Zhou CB,Lu H,Chen YX,Fang JY

更新日期：2019-03-01 00:00:00

abstract：:An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...

journal_title：Gut

authors： MacPherson BR,Albertini RJ,Beeken WL

更新日期：1976-02-01 00:00:00

abstract：:This report presents a patient with proximal small bowel cystic pneumatosis associated with poorly controlled coeliac disease and pseudo-obstruction. Cystic pneumatosis is rare in the proximal small bowel and we can find no report of its occurrence in association with coeliac disease. ...

journal_title：Gut

authors： Sackier JM,Smith EJ,Wood CB

更新日期：1988-06-01 00:00:00

abstract：:The faecal blood loss of six alcoholic subjects with normal gastric mucosa, six with superficial gastritis, and six with atrophic gastritis was studied before and during ingestion of 40% v/v ethanol using (51)Cr-tagged red blood cells. No significant change in faecal blood loss was observed in the normal mucosa and su...

journal_title：Gut

authors： Dinoso VP Jr,Meshkinpour H,Lorber SH

更新日期：1973-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. We previously showed that siRNA against collagen-specific chaperone protein gp46, encapsulated in vi...

journal_title：Gut

authors： Ishiwatari H,Sato Y,Murase K,Yoneda A,Fujita R,Nishita H,Birukawa NK,Hayashi T,Sato T,Miyanishi K,Takimoto R,Kobune M,Ota S,Kimura Y,Hirata K,Kato J,Niitsu Y

更新日期：2013-09-01 00:00:00

abstract：:Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...

journal_title：Gut

authors： Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

更新日期：1995-09-01 00:00:00