Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice.

abstract：:A clinical, biochemical, and pathological study is recorded of 50 patients in whom a diagnosis of idiopathic steatorrhea had been made and who had ;flat' jejunal biopsies. It is suggested that there is an underlying constitutional defect, not yet clearly defined, and that possibly secondary intestinal infection allows...

journal_title：Gut

authors： COOKE WT,FONE DJ,COX EV,MEYNELL MJ,GADDIE R

更新日期：1963-09-01 00:00:00

abstract：:The major end products of fermentation, short chain fatty acids (acetate, propionate, butyrate) were measured in portal and peripheral venous blood after the caecal instillation of lactulose at surgery in patients undergoing elective cholecystectomy. Blood samples for short chain fatty acid measurement were taken befo...

journal_title：Gut

authors： Peters SG,Pomare EW,Fisher CA

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The potential of endoscopic mucosal resection (EMR) for treating flat dysplastic lesions in chronic ulcerative colitis (CUC) has not been addressed so far. Historically, such lesions were referred for colectomy. Furthermore, there are only limited data to support endoscopic resection of exophytic adenoma-lik...

journal_title：Gut

authors： Hurlstone DP,Sanders DS,Atkinson R,Hunter MD,McAlindon ME,Lobo AJ,Cross SS,Thomson M

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS:We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk ...

journal_title：Gut

authors： Mocellin S,Verdi D,Pooley KA,Nitti D

更新日期：2015-08-01 00:00:00

abstract：:Bacterial contamination of gastrointestinal fibre-endoscopes is a potential source of clinically significant infection. Aqueous 2% alkaline glutaraldehyde adequately disinfects fibre-endoscopes but may cause serious sensitivity reactions among endoscopy staff. A new 'closed-system' disinfecting apparatus is described ...

journal_title：Gut

authors： O'Connor HJ,Rothwell J,Maxwell S,Lincoln C,Axon AT

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:The effect of histamine H2 receptor antagonists on gastric emptying is controversial. AIMS:To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. PATIENTS AND METHODS:Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (E...

journal_title：Gut

authors： Parkman HP,Urbain JL,Knight LC,Brown KL,Trate DM,Miller MA,Maurer AH,Fisher RS

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol. These transporters are also expressed in the liver and might regulate biliary sterol secretion. AIMS:This study was therefore conducted to determine the biliary se...

journal_title：Gut

authors： Sudhop T,Sahin Y,Lindenthal B,Hahn C,Lüers C,Berthold HK,von Bergmann K

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Intrasphincteric injection of botulinum toxin (Botx) has been proposed as treatment for oesophageal achalasia. However, the predictors of response and optimal dose remain unclear. AIMS:To compare the effect of different doses of Botx and to identify predictors of response. PATIENTS/METHODS:A total of 118 a...

journal_title：Gut

authors： Annese V,Bassotti G,Coccia G,Dinelli M,D'Onofrio V,Gatto G,Leandro G,Repici A,Testoni PA,Andriulli A

更新日期：2000-05-01 00:00:00

abstract：:We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

journal_title：Gut

authors： McGuinness EE,Morgan RG,Wormsley KG

更新日期：1987-01-01 00:00:00

abstract：:These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...

journal_title：Gut

authors： Rutter MD,East J,Rees CJ,Cripps N,Docherty J,Dolwani S,Kaye PV,Monahan KJ,Novelli MR,Plumb A,Saunders BP,Thomas-Gibson S,Tolan DJM,Whyte S,Bonnington S,Scope A,Wong R,Hibbert B,Marsh J,Moores B,Cross A,Sharp L

更新日期：2020-02-01 00:00:00

abstract：:The typical macroscopic features of Crohn's disease have been well described and are widely regarded as sufficient to diagnose the disease at laparotomy. We report six patients undergoing laparotomy for symptomatic Crohn's disease, shown radiologically, who were found to have macroscopically normal small bowel despite...

journal_title：Gut

authors： Butterworth RJ,Williams GT,Hughes LE

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...

journal_title：Gut

authors： Kastrinos F,Steyerberg EW,Balmaña J,Mercado R,Gallinger S,Haile R,Casey G,Hopper JL,LeMarchand L,Lindor NM,Newcomb PA,Thibodeau SN,Syngal S,Colon Cancer Family Registry.

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Meal ingestion is often associated with exacerbation of gastrointestinal symptoms in subjects with irritable bowel syndrome (IBS). Furthermore, recent preliminary data suggest that 5-hydroxytryptamine (5-HT) concentration in platelet poor plasma is elevated following meal ingestion in some subjects with diar...

journal_title：Gut

authors： Houghton LA,Atkinson W,Whitaker RP,Whorwell PJ,Rimmer MJ

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS:To evaluate wh...

journal_title：Gut

authors： Korponay-Szabó IR,Laurila K,Szondy Z,Halttunen T,Szalai Z,Dahlbom I,Rantala I,Kovács JB,Fésüs L,Mäki M

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....

journal_title：Gut

authors： Nieuwenburg SAV,Vuik FER,Kruip MJHA,Kuipers EJ,Spaander MCW

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Hypersensitivity of gastric afferent pathways may play an aetiological role in symptoms of functional dyspepsia. AIMS:To determine whether patients with severe organic dyspepsia (associated with tissue irritation/injury) and those with functional dyspepsia (no detectable tissue irritation) differ in their p...

journal_title：Gut

authors： Mertz H,Fullerton S,Naliboff B,Mayer EA

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...

journal_title：Gut

authors： Comino I,Real A,de Lorenzo L,Cornell H,López-Casado MÁ,Barro F,Lorite P,Torres MI,Cebolla A,Sousa C

更新日期：2011-07-01 00:00:00

abstract：:Three-day faecal collections were obtained from 87 patients with a variety of gastroenterological diagnoses and 12 control subjects while consuming normal diets. Faecal weight, total fatty acids, and the proportion of hydroxystearic (OHSA) acid were measured. All patients had some easily detectable hydroxystearic acid...

journal_title：Gut

authors： Wiggins HS,Pearson JR,Walker JG,Russell RI,Kellock TD

更新日期：1974-08-01 00:00:00

abstract：:Two patients who developed biochemical and histological evidence of hepatitis while taking the anti-anginal drug perhexiline maleate are described. The pathological changes were those of mild to moderate fatty change together with a hepatitis which resembled alcoholic hepatitis, including in one patient the presence o...

journal_title：Gut

authors： Lewis D,Wainwright HC,Kew MC,Zwi S,Isaacson C

更新日期：1979-03-01 00:00:00

abstract：:Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed....

journal_title：Gut

authors： Whorwell PJ,Baldwin RC,Wright R

更新日期：1976-09-01 00:00:00

abstract：:In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without ev...

journal_title：Gut

authors： Triger DR,Charlton CA,Ward AM

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVE:Cathepsin K is a lysosomal cysteine protease that has pleiotropic roles in bone resorption, arthritis, atherosclerosis, blood pressure regulation, obesity and cancer. Recently, it was demonstrated that cathepsin K-deficient (Ctsk(-/-) ) mice are less susceptible to experimental autoimmune arthritis and enceph...

journal_title：Gut

authors： Sina C,Lipinski S,Gavrilova O,Aden K,Rehman A,Till A,Rittger A,Podschun R,Meyer-Hoffert U,Haesler R,Midtling E,Pütsep K,McGuckin MA,Schreiber S,Saftig P,Rosenstiel P

更新日期：2013-04-01 00:00:00

abstract：:Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...

journal_title：Gut

authors： Fiasse R,Lurhuma AZ,Cambiaso CL,Masson PL,Dive C

更新日期：1978-07-01 00:00:00

abstract：:Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception-that is, its relation to clinical symptoms-remains unclear. Data indicate that sensory dysfunction is associated with altered re...

journal_title：Gut

authors： Azpiroz F

更新日期：2002-07-01 00:00:00

abstract：:A prospective, randomised, comparative study was performed to assess the need for a pure alcohol injection after an epinephrine injection in the arrest of active peptic ulcer bleeding. Sixty four patients with active ulcer bleeding were enrolled in the study. The two groups (epinephrine and epinephrine plus pure alcoh...

journal_title：Gut

authors： Lin HJ,Perng CL,Lee SD

更新日期：1993-09-01 00:00:00

abstract：:Two patients with specific pancreatic amylase deficiency are described. The greatly reduced pancreatic amylase activity was not due to an enzymatically inactive amylase molecule but to an almost complete absence of the molecule itself. The findings are of diagnostic importance as they show that low pancreatic amylase ...

journal_title：Gut

authors： Sjölund K,Häggmark A,Ihse I,Skude G,Kärnström U,Wikander M

更新日期：1991-05-01 00:00:00

abstract：:The influence of dehydrocholate on bromsulphtalein relative-storage capacity, bilary transport maximum (Tm), and fractional transfer rates between plasma, liver and bile have been studied in unanaesthetized dogs. In six dogs, storage capacity, Tm, and fractional transfer rates from plasma to liver, liver to bile, and ...

journal_title：Gut

authors： Delage Y,Erlinger S,Duval M,Bpenhamou JP

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplas...

journal_title：Gut

authors： Buisine MP,Devisme L,Savidge TC,Gespach C,Gosselin B,Porchet N,Aubert JP

更新日期：1998-10-01 00:00:00

abstract：:Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...

journal_title：Gut

authors： Gazzard BG,Henderson JM,Williams R

更新日期：1976-07-01 00:00:00

abstract：:Measurements of cell proliferation can be used as biomarkers of preneoplastic change. In this study, two immunocytochemical methods that measure different components of the cell cycle were compared to assess cell proliferation on biopsy samples from human colonic mucosa. These methods are based on a monoclonal antibod...

journal_title：Gut

authors： Weisgerber UM,Boeing H,Nemitz R,Raedsch R,Waldherr R

更新日期：1993-11-01 00:00:00