Abstract:
:The typical macroscopic features of Crohn's disease have been well described and are widely regarded as sufficient to diagnose the disease at laparotomy. We report six patients undergoing laparotomy for symptomatic Crohn's disease, shown radiologically, who were found to have macroscopically normal small bowel despite careful examination of the bowel by an experienced surgeon. In four cases resection was deferred, but all subsequently deteriorated and required further surgery. Minor abnormalities found by balloon examination of the terminal ileum prompted resection in two further patients. Histology showed an unusually superficial distribution of inflammation, which could explain the negative findings at laparotomy. We conclude that normal laparotomy findings alone do not exclude a diagnosis of clinically important small bowel Crohn's disease. Crohn's disease should be considered in patients with persisting symptoms after negative laparotomy.
journal_name
Gutjournal_title
Gutauthors
Butterworth RJ,Williams GT,Hughes LEdoi
10.1136/gut.33.1.140subject
Has Abstractpub_date
1992-01-01 00:00:00pages
140-2issue
1eissn
0017-5749issn
1468-3288journal_volume
33pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:To evaluate the relation between non-steroidal anti-inflammatory drugs (NSAIDs) and colitis due to inflammatory bowel disease. METHODS:A case-control study was conducted using a prospectively constructed, record linkage database containing hospital event and dispensed drug data (1989-93). The study populati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.5.619
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.2.201
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN:Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317632
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316234
更新日期:2018-11-01 00:00:00
abstract::Electrical activity of the colon was investigated in six healthy volunteers and 22 patients presenting functional colonic disorders associated with pain, constipation, or diarrhoea. Myoelectrical activity during 10 hours, including two daily meals, was recorded from eight groups of nickel-chrome electrodes using a 1.5...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.6.480
更新日期:1980-06-01 00:00:00
abstract::Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of the infection. A random cross sectional study was performed of H pylori infection in the adult population of San Marino, a European country with high gastric cancer rate, to assess its prevalence and to evaluate its ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.6.838
更新日期:1995-06-01 00:00:00
abstract::We have studied B-lymphocyte function in 39 patients with Crohn's disease and 35 normal individuals using a reverse haemolytic plaque assay as the effector system. Ten patients had active Crohn's disease, the others being in an inactive state of the disease. Compared with normal individuals, the Crohn's disease patien...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.11.1255
更新日期:1984-11-01 00:00:00
abstract::A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation ove...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.12.1011
更新日期:1971-12-01 00:00:00
abstract::Six cases of faecal stasis in active proctocolitis are reported. In each case the left colon was severely diseased but the right colon was unaffected. X-ray studies showed retention of barium in the right colon for as long as five weeks. In two patients subacute intestinal obstruction developed and in three patients c...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.3.4.301
更新日期:1962-12-01 00:00:00
abstract::Single angiodysplasias were demonstrated by preoperative angiography in four patients. In two cases the lesions were in the terminal ileum, and were situated just above the caecum in the other two patients. In three patients, contrast medium was extravasated into the bowel lumen. Histological verification was obtained...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.12.977
更新日期:1973-12-01 00:00:00
abstract::The cholesteryl-14C-octanoate breath test was used to monitor the intraluminal enzymatic activity of pancreatin preparations in six patients with severe pancreatic insufficiency. Conventional enzyme replacement, with cimetidine as an adjunct, was compared to supplementation with enteric coated microspheres. In healthy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.11.1324
更新日期:1990-11-01 00:00:00
abstract::The quantification of gastric, pancreatic, biliary, and small bowel functions in man often requires the use of intestinal tubes. In this study, the presence of a transpyloric tube did not alter gastric emptying, acid secretion, or serum gastrin levels in response to an ordinary solid meal. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.16.10.777
更新日期:1975-10-01 00:00:00
abstract::A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.2.111
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:Gastric mucosal surface hydrophobicity (GMSH) is an essential component of the mucosal defence system that is decreased by Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Gastric ulcers occur predominantly in elderly subjects, and may thus reflect diminished mucosal resistance. AIMS:...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.4.465
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321609
更新日期:2020-12-17 00:00:00
abstract::On the basis of circumstantial clinical and experimental evidence, it has been suggested that enteroglucagon (EG) may act as an enterotrophic factor. This study was undertaken to evaluate the effects of long term in vivo immunoneutralisation of EG, using monoclonal antibodies to EG, on the hyperplastic ileal response ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.9
更新日期:1987-01-01 00:00:00
abstract::Fasting and postprandial plasma concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured by a high pressure liquid chromatography-enzymatic assay in nine healthy subjects. The mean value of each bile acid concentration increased significantly (2.4-4.7 times) in t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.3.249
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:In normal gastric epithelium, MUC5AC is detected in superficial epithelium associated with Lewis type 1 antigens and MUC6 is detected in antral glands with Lewis type 2. Therefore, the stomach constitutes an excellent model to examine the role of glycosyltransferases in determining the specificity of apomuci...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.3.349
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Gastric cancer (GC) remains difficult to cure due to heterogeneity in a clinical challenge and the molecular mechanisms underlying this disease are complex and not completely understood. Accumulating evidence suggests that microRNAs (miRNAs) play an important role in GC, but the role of specific miRNAs involv...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306640
更新日期:2015-02-01 00:00:00
abstract::A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.12.1660
更新日期:1993-12-01 00:00:00
abstract::To determine the optimum dose of ispaghula husk in patients with irritable bowel syndrome (IBS) and to assess the correlation, if any between the relief in patients' symptoms and the whole gut transit time, and the increase in stool weight, a two part study was carried out. In part 1, 14 male patients were given ispag...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.28.2.150
更新日期:1987-02-01 00:00:00
abstract::Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.5.383
更新日期:1981-05-01 00:00:00
abstract::This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained. Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine. Overiectomized rats...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.8.641
更新日期:1970-08-01 00:00:00
abstract::Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carri...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.1.61
更新日期:1983-01-01 00:00:00
abstract::Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.8.699
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:An endoscopic procedure that uses a pH indicator called phenol red to assess Helicobacter pylori infected gastric mucosa has recently been developed. This test makes it possible to take biopsy specimens from H pylori infected areas. AIM:This test was applied to patients with early gastric cancers to clarify...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.1.20
更新日期:1998-01-01 00:00:00
abstract::In order to examine the relationship of various haemodynamic parameters in two different liver diseases, 10 patients with cirrhosis of liver and 14 patients with non-cirrhotic portal fibrosis were studied. In cirrhotics, mean (+/- SD) wedged hepatic (25.8 +/- 6.4 mmHg), intrahepatic (24.5 +/- 6.2 mmHg) and intraspleni...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.3.260
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN:By utilising large ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304037
更新日期:2014-05-01 00:00:00
abstract::Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.1.54
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314205
更新日期:2018-02-01 00:00:00