Abstract:
:This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained. Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine. Overiectomized rats treated with 17B-oestradiol (short-term treatment) showed a statistically significant reduction in gastric acid secretion induced with all the secretagogues, but the results when rats were treated with testosterone were inconsistent. In animals given gastrin or histamine gastric acid secretion was reduced and was of statistical significance with gastrin (0.02 < p < 0.05) but not with histamine (0.05 < p > 0.1). It is concluded that a high oestrogen blood level is capable of inhibiting effectively acid gastric secretion in both sexes except that a higher level of blood oestrogen is required in the male. The results showed further that of all the sex hormones used, only oestrogen had a significant effect on gastric acid secretion.
journal_name
Gutjournal_title
Gutauthors
Amure BO,Omole AAdoi
10.1136/gut.11.8.641subject
Has Abstractpub_date
1970-08-01 00:00:00pages
641-5issue
8eissn
0017-5749issn
1468-3288journal_volume
11pub_type
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