Gastric emptying of two radiolabelled antacids.


:The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an eight hour fast each subject ingested a standardised meal of 95.7 MJ (400 kcal). One hour later 10 ml of one of the two antacids previously labelled with 99mTc was administered. Serial detection by anterior and posterior projection of the amount of antacid retained in the stomach was performed to determine gastric emptying of antacid. One week later the study was repeated under the same conditions with the other antacid also labelled with 99mTc. The mean (SD) percentages of antacid retained in the stomach fit a linear model with a t1/2 of 86.6 (15.3) minutes for magaldrate and 52.3 (5.2) minutes for Maalox (p less than 0.01). When the mean percentages of retention at six time intervals were compared for both antacids, it was found that Maalox emptied much faster (p less than 0.01 at 15 and 30 minutes, p less than 0.02 at 45, 60, 75, and 90 minutes).






Monés J,Carrió I,Roca M,Estorch M,Calabuig R,Sainz S,Martinez-Duncker C,Vilardell F





Has Abstract


1991-02-01 00:00:00














  • Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels.

    abstract:BACKGROUND/AIM:To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. METHODS:HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC an...


    pub_type: 杂志文章


    authors: Yuen MF,Tanaka Y,Shinkai N,Poon RT,But DY,Fong DY,Fung J,Wong DK,Yuen JC,Mizokami M,Lai CL

    更新日期:2008-01-01 00:00:00

  • Immunocytochemical study of the interaction of soybean trypsin inhibitor with rat intestinal mucosa.

    abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...


    pub_type: 杂志文章


    authors: Wilson PA,Melmed RN,Hampe MM,Holt SJ

    更新日期:1978-04-01 00:00:00

  • Severe haemolysis associated with hepatitis A and normal glucose-6-phosphate dehydrogenase status.

    abstract::We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency. ...


    pub_type: 杂志文章


    authors: Lyons DJ,Gilvarry JM,Fielding JF

    更新日期:1990-07-01 00:00:00

  • Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine.

    abstract::Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...


    pub_type: 杂志文章


    authors: Korman MG,Soveny C,Hansky J

    更新日期:1971-11-01 00:00:00

  • Extracorporeal lithotripsy of pancreatic stones in patients with chronic pancreatitis and pain: a prospective follow up study.

    abstract::Extracorporeal shock wave lithotripsy of pancreatic duct stones (largest stone 12 (SD) 6 mm) was performed in 24 patients with abdominal pain and a dilated duct system (main pancreatic duct 10 (3) mm). The procedure was well tolerated in all but two patients, who had a mild pancreatitic attack immediately after lithot...


    pub_type: 杂志文章


    authors: Sauerbruch T,Holl J,Sackmann M,Paumgartner G

    更新日期:1992-07-01 00:00:00

  • Defective jejunal brush border membrane sodium/proton exchange in association with lethal familial protracted diarrhoea.

    abstract::The spectrum of clinical disease associated with specific defects in jejunal brush border membrane sodium/proton exchange is poorly defined and only two patients have been described so far. Jejunal brush border membrane transport studies were performed in a boy who presented with lethal familial protracted diarrhoea i...


    pub_type: 杂志文章


    authors: Keller KM,Wirth S,Baumann W,Sule D,Booth IW

    更新日期:1990-10-01 00:00:00

  • Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans.

    abstract:BACKGROUND:Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying. AIMS:To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-...


    pub_type: 杂志文章


    authors: Schirra J,Nicolaus M,Roggel R,Katschinski M,Storr M,Woerle HJ,Göke B

    更新日期:2006-02-01 00:00:00

  • Association study of PHOX2B as a candidate gene for Hirschsprung's disease.

    abstract:BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...


    pub_type: 杂志文章


    authors: Garcia-Barceló M,Sham MH,Lui VC,Chen BL,Ott J,Tam PK

    更新日期:2003-04-01 00:00:00

  • Portal and systemic haemodynamic action of N-acetylcysteine in patients with stable cirrhosis.

    abstract::The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a signif...


    pub_type: 杂志文章


    authors: Jones AL,Bangash IH,Bouchier IA,Hayes PC

    更新日期:1994-09-01 00:00:00

  • Clinical relevance of an unfused pancreatic duct system.

    abstract::In man, the main pancreatic duct is normally derived from ventral and dorsal embryological buds of the pancreas. In a minority of people, failure of fusion of the two buds results in separate drainage of the dorsal and ventral pancreas, so that the accessory duct provides the main drainage for the gland. Patients with...


    pub_type: 杂志文章


    authors: Mitchell CJ,Lintott DJ,Ruddell WS,Losowsky MS,Axon AT

    更新日期:1979-12-01 00:00:00

  • Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains.

    abstract:BACKGROUND:Helicobacter pylori strains possessing the cagA gene are thought to induce interleukin 8 (IL-8) in gastric mucosa. However, it is still unclear whether a relation exists between the cagA gene and the expression patterns of cytokines other than IL-8. AIMS:To investigate the relation between the cagA gene and...


    pub_type: 杂志文章


    authors: Yamaoka Y,Kita M,Kodama T,Sawai N,Kashima K,Imanishi J

    更新日期:1997-10-01 00:00:00

  • PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.

    abstract:OBJECTIVES:Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver inflammation and liver failure, the regulation of hepatic cell death causing AIH remains poorly understood. The aim of t...


    pub_type: 杂志文章


    authors: He GW,Günther C,Kremer AE,Thonn V,Amann K,Poremba C,Neurath MF,Wirtz S,Becker C

    更新日期:2017-04-01 00:00:00

  • Liver in obesity.

    abstract::We report on clinical, nutritional, and hepatic histological findings in 50 non-selected obese subjects (mean overweight +74%; range +21-138%). The pathogenesis of the liver damage was assessed with the help of multidimensional analysis of a number of clinical variables. According to the severity of the hepatic lesion...


    pub_type: 杂志文章


    authors: Braillon A,Capron JP,Hervé MA,Degott C,Quenum C

    更新日期:1985-02-01 00:00:00

  • Evaluation of indium scintigraphy in patients with active inflammatory bowel disease.

    abstract::Recent reports have indicated a possible role for 111Indium leucocyte scintigraphy in the management of patients with acute inflammatory bowel disease. Our experience with this technique in 15 patients (nine with ulcerative colitis, six with Crohn's disease) is described. Perfect agreement was not obtained between sci...


    pub_type: 杂志文章


    authors: Buxton-Thomas MS,Dickinson RJ,Maltby P,Hunter JO,Wraight EP

    更新日期:1984-12-01 00:00:00

  • Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa.

    abstract:OBJECTIVE:Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity ...


    pub_type: 杂志文章


    authors: Reyes-Uribe L,Wu W,Gelincik O,Bommi PV,Francisco-Cruz A,Solis LM,Lynch PM,Lim R,Stoffel EM,Kanth P,Samadder NJ,Mork ME,Taggart MW,Milne GL,Marnett LJ,Vornik L,Liu DD,Revuelta M,Chang K,You YN,Kopelovich L,Wistub

    更新日期:2020-07-08 00:00:00

  • Oxyntic endocrine cells of hypergastrinaemic patients. Differential response to antrectomy or octreotide.

    abstract:BACKGROUND/AIMS:To evaluate the response of endocrine cells of the gastric oxyntic mucosa in hypergastrinaemic patients to either antrectomy or treatment with the somatostatin analogue octreotide. PATIENTS:(a) Two patients with enterochromaffin-like (ECL) cell carcinoid and chronic atrophic gastritis, treated with ant...


    pub_type: 临床试验,杂志文章


    authors: D'Adda T,Annibale B,Delle Fave G,Bordi C

    更新日期:1996-05-01 00:00:00

  • First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying.

    abstract:BACKGROUND:Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS:To study the effect of modulat...


    pub_type: 杂志文章


    authors: Oneta CM,Simanowski UA,Martinez M,Allali-Hassani A,Parés X,Homann N,Conradt C,Waldherr R,Fiehn W,Coutelle C,Seitz HK

    更新日期:1998-11-01 00:00:00

  • Effect of gastric acid suppressants on human gastric motility.

    abstract:BACKGROUND:The effect of histamine H2 receptor antagonists on gastric emptying is controversial. AIMS:To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. PATIENTS AND METHODS:Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (E...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Parkman HP,Urbain JL,Knight LC,Brown KL,Trate DM,Miller MA,Maurer AH,Fisher RS

    更新日期:1998-02-01 00:00:00

  • Enhanced mucosal permeability and nitric oxide synthase activity in jejunum of mast cell deficient mice.

    abstract:BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...


    pub_type: 杂志文章


    authors: Komatsu S,Grisham MB,Russell JM,Granger DN

    更新日期:1997-11-01 00:00:00

  • The genetic jigsaw of inflammatory bowel disease.

    abstract::Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence th...


    pub_type: 杂志文章,评审


    authors: Watts DA,Satsangi J

    更新日期:2002-05-01 00:00:00

  • Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery.

    abstract::The major end products of fermentation, short chain fatty acids (acetate, propionate, butyrate) were measured in portal and peripheral venous blood after the caecal instillation of lactulose at surgery in patients undergoing elective cholecystectomy. Blood samples for short chain fatty acid measurement were taken befo...


    pub_type: 杂志文章


    authors: Peters SG,Pomare EW,Fisher CA

    更新日期:1992-09-01 00:00:00

  • Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease.

    abstract:OBJECTIVE:Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment. DESIGN:50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolo...


    pub_type: 杂志文章


    authors: Rimola J,Rodriguez S,García-Bosch O,Ordás I,Ayala E,Aceituno M,Pellisé M,Ayuso C,Ricart E,Donoso L,Panés J

    更新日期:2009-08-01 00:00:00

  • Effect of Helicobacter pylori eradication on the treatment of gastro-oesophageal reflux disease.

    abstract::The important issue of whether Heliobacter pylori eradication leads to increased reflux has been the subject of many apparently contradictory publications, but when we asked two leading authorities to give us their views, there turned out to be considerable consensus, as you can read below. ...


    pub_type: 杂志文章


    authors: Richter JE

    更新日期:2004-02-01 00:00:00

  • Ranitidine increases the bioavailability of postprandial ethanol by the reduction of first pass metabolism.

    abstract::Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...


    pub_type: 临床试验,杂志文章


    authors: Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

    更新日期:1995-09-01 00:00:00

  • Laboratory diagnosis of gastrointestinal bleeding.

    abstract::The value of four tests to detect occult alimentary blood loss has been compared in normal subjects, in patients with and without alimentary disease, and in patients with congestive heart failure, and the sensitivities of these tests have been compared using suspensions of blood alone and blood in faeces. The Occultes...


    pub_type: 杂志文章


    authors: Steingold L,Roberts AA

    更新日期:1961-03-01 00:00:00

  • Hepatitis C reactivation in patients with chronic infection with genotypes 1b and 2c: a retrospective cohort study of 206 untreated patients.

    abstract:BACKGROUND:We previously described hepatitis reactivation in two carriers of the hepatitis C virus (HCV) genotype 2c. AIM:To assess the relationship between HCV genotypes and risk of hepatitis reactivation, we studied the course of aminotransferases in patients infected with the two relevant genotypes in Italy. PATIE...


    pub_type: 杂志文章


    authors: Rumi MG,De Filippi F,La Vecchia C,Donato MF,Gallus S,Del Ninno E,Colombo M

    更新日期:2005-03-01 00:00:00

  • The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.

    abstract:BACKGROUND:During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. This is illustrated by the non-neoplastic gastric-type heteroplasias present at birth in the pericaecal region of Cdx2(+/-) mice. Furthermore...


    pub_type: 杂志文章


    authors: Bonhomme C,Duluc I,Martin E,Chawengsaksophak K,Chenard MP,Kedinger M,Beck F,Freund JN,Domon-Dell C

    更新日期:2003-10-01 00:00:00

  • Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake.

    abstract:BACKGROUND AND AIMS:Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces apoptosis in transformed cells and is considered as an agent for cancer therapy. As there is evidence that TRAIL is also essential for apoptosis in animal models of liver injury, we investigated the role of TRAIL in viral hepat...


    pub_type: 杂志文章


    authors: Mundt B,Wirth T,Zender L,Waltemathe M,Trautwein C,Manns MP,Kühnel F,Kubicka S

    更新日期:2005-11-01 00:00:00

  • Urea breath tests in the management of Helicobacter pylori infection.

    abstract::The 13/14C-Urea breath test (UBT) is based on the simple principle that a solution of isotopically labelled urea will be rapidly hydrolysed by the abundantly expressed urease of H pylori. The released 13/14CO2 is absorbed across the mucus layer to the gastric mucosa and hence, via the systemic circulation, excreted in...


    pub_type: 杂志文章,评审


    authors: Logan RP

    更新日期:1998-07-01 00:00:00

  • Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

    abstract::We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac dise...


    pub_type: 杂志文章


    authors: Kagnoff MF,Paterson YJ,Kumar PJ,Kasarda DD,Carbone FR,Unsworth DJ,Austin RK

    更新日期:1987-08-01 00:00:00