Abstract:
BACKGROUND:It has been suggested that Mycobacterium paratuberculosis is the cause of Crohn's disease. In a previous report the immediate effect of two years treatment with antituberculous chemotherapy showed no clinical benefit. AIMS:To assess both the immediate and longer term effect of treatment on the disease. METHODS:Patients were followed for five years from their date of entry to the study. One hundred and thirty patients entered the initial study, and of these 111 (81%) were followed regularly. RESULTS:Overall, there was no evidence of consistent benefit or disadvantage from antituberculous chemotherapy in any of the assessments made, including the number of acute relapses, surgical episodes, hospital admissions, disease activity, blood tests, or medication required for Crohn's disease during the follow up period. CONCLUSION:The absence of any benefit at the end of the initial two year trial period, and during the three year subsequent follow up, fails to support the hypothesis that mycobacteria play an important part in the pathogenesis of Crohn's disease, or that antituberculous chemotherapy may be of benefit.
journal_name
Gutjournal_title
Gutauthors
Thomas GA,Swift GL,Green JT,Newcombe RG,Braniff-Mathews C,Rhodes J,Wilkinson S,Strohmeyer G,Kreuzpainter Gdoi
10.1136/gut.42.4.497subject
Has Abstractpub_date
1998-04-01 00:00:00pages
497-500issue
4eissn
0017-5749issn
1468-3288journal_volume
42pub_type
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