Abstract:
:A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient and had no proteinuria. Studies on two of the affected children with subcellular fractionation of the uptake of radioactive vitamin B12 by ileal tissue in vivo indicate a defect in the ileal receptors for IF-bound vitamin B12. These findings are different from the single in vitro experiment on a patient with this condition that has been previously reported.
journal_name
Gutjournal_title
Gutauthors
Burman JF,Jenkins WJ,Walker-Smith JA,Phillips AD,Sourial NA,Williams CB,Mollin DLdoi
10.1136/gut.26.3.311subject
Has Abstractpub_date
1985-03-01 00:00:00pages
311-4issue
3eissn
0017-5749issn
1468-3288journal_volume
26pub_type
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