Abstract:
BACKGROUND AND AIMS:Major histocompatibility complex class II deficient (Aalpha0/0) mice have decreased CD4+ T cells, making them immunologically similar to patients with acquired immunodeficiency syndrome (AIDS). Both patients with AIDS and Aalpha0/0 mice have hypertrophic gastric folds. To clarify the mechanism of gastric mucosal hyperplasia, we investigated the pathophysiology and the role of the innate immunity in the stomach of Aalpha0/0 mice. METHODS:Stomachs from 1-6 month old Aalpha0/0 mice, kept under specific pathogen free conditions, were examined at 1 month intervals histologically and immunohistochemically. Gene expression of proinflammatory cytokines, Toll-like receptors (TLRs), cyclooxygenase (COX)-2, and myeloperoxidase (MPO) activity in the gastric mucosa was investigated. Serum gastrin levels and gastric acidity were measured. Bacterial culture of the stomach was performed. To clarify the roles of hypergastrinaemia in the gastric mucosa, a gastrin receptor antagonist (AG041R) was administered. RESULTS:Aalpha0/0 mice had a diffusely thick corpus mucosa with infiltration of CD11b+ granulocytes and macrophages. Anti-Ki67 staining demonstrated expansion of the proliferating neck zone. Gene expression of interleukin 1beta, interferon gamma, TLR-2, TLR-4, and COX-2 were upregulated, and MPO activity was increased. Only a small amount of non-pathogenic bacteria was detected in the stomach. Serum gastrin levels and Reg-Ialpha positive cells in the gastric mucosa increased, despite normal gastric acidity. After treatment with AG041R, gastric mucosal thickness was significantly reduced. CONCLUSION:Persistent activation of innate immunity in the stomach induced gastric mucosal hyperplasia through upregulation of gastrin synthesis in Aalpha0/0 mice, suggesting a pathophysiology similar to the gastric changes in patients with AIDS.
journal_name
Gutjournal_title
Gutauthors
Fukui T,Nishio A,Okazaki K,Uza N,Ueno S,Kido M,Inoue S,Kitamura H,Kiriya K,Ohashi S,Asada M,Tamaki H,Matsuura M,Kawasaki K,Suzuki K,Uchida K,Fukui H,Nakase H,Watanabe N,Chiba Tdoi
10.1136/gut.2005.077917keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
607-15issue
5eissn
0017-5749issn
1468-3288pii
gut.2005.077917journal_volume
55pub_type
杂志文章相关文献
GUT文献大全abstract::The amounts of lactase (EC 3.2.1.23), sucrase (EC 3.2.1.48), maltase (EC 3.2.1.20), microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.8.662
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Both bile salts and glutathione participate in the generation of canalicular bile flow. In this work, we have investigated the effect of different bile salts on hepatic glutathione metabolism. METHODS:Using the isolated and perfused rat liver, we studied hepatic glutathione content, and metabolism ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.5.701
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.127167
更新日期:2007-12-01 00:00:00
abstract::Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.8.1075
更新日期:2003-08-01 00:00:00
abstract::Heartburn is a common symptom affecting 21-44% of the adult population on a monthly basis. Oesophagitis is less common, affecting 2% of individuals. Epidemiological studies have shown that patients with gastro-oesophageal reflux disease (GORD) have similar incidence rates of Helicobacter pylori infection as do control...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.45.2008.i13
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.51.5.701
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301078
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. AIMS:To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.232
更新日期:1998-08-01 00:00:00
abstract::Prostaglandins (PGs) are synthesised by gastric mucosa, and have been shown to inhibit gastric acid secretion and ulcer formation in man and experimental animals. Recently exogenous PGs, mainly of the E group, have been used for the treatment of peptic ulcer disease. We therefore searched for a drug that would stimula...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.10.882
更新日期:1979-10-01 00:00:00
abstract::In a study of low dose interferon alfa-2b in 587 patients expected to show a good response to treatment, 76-87% patients in different countries had alanine amino-transferase activities returned to normal after four months' treatment, 49-72% were negative for hepatitis B virus (HBV)-DNA, 51-66% were negative for hepati...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gut.34.2_suppl.s99
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Several cases of acute colitis induced by non-steroidal anti-inflammatory drugs (NSAIDs) have been reported but the general role of recent NSAID intake as a risk factor for acute diarrhoea has not been studied to date. The aim of our study was to determine whether the risk of acute diarrhoea is incr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.2.260
更新日期:2003-02-01 00:00:00
abstract::The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine. In healthy subjects, the oxyntic, antral and duodenal muco...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.4.283
更新日期:1981-04-01 00:00:00
abstract::The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.6.473
更新日期:1975-06-01 00:00:00
abstract::The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2019-318448
更新日期:2019-10-01 00:00:00
abstract::Central reading, that is, independent, off-site, blinded review or reading of imaging endpoints, has been identified as a crucial component in the conduct and analysis of inflammatory bowel disease clinical trials. Central reading is the final step in a workflow that has many parts, all of which can be improved. Furth...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2020-320690
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-313213
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Enterochromaffin cell-derived serotonin (5-HT) promotes intestinal inflammation. We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal inflammation; moreover,...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-304901
更新日期:2014-06-01 00:00:00
abstract::Thirty two patients with empyema of the gall bladder were identified among 1327 cases of gall-bladder disease presenting to one hospital over a six year period. Abdominal pain had been present for a median of eight days and, in eight cases, for between one and four months. In a few cases, the disease was painless and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.12.1183
更新日期:1983-12-01 00:00:00
abstract::A prospective, randomised, comparative study was performed to assess the need for a pure alcohol injection after an epinephrine injection in the arrest of active peptic ulcer bleeding. Sixty four patients with active ulcer bleeding were enrolled in the study. The two groups (epinephrine and epinephrine plus pure alcoh...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.9.1182
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Sodium butyrate, a product of colonic bacterial fermentation, is able to inhibit cell proliferation and to stimulate cell differentiation of colonic epithelial cell lines. It has been proposed that these cellular effects could be linked to its ability to cause hyperacetylation of histone through the inhibiti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.4.507
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:We previously described hepatitis reactivation in two carriers of the hepatitis C virus (HCV) genotype 2c. AIM:To assess the relationship between HCV genotypes and risk of hepatitis reactivation, we studied the course of aminotransferases in patients infected with the two relevant genotypes in Italy. PATIE...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.048009
更新日期:2005-03-01 00:00:00
abstract::On three occasions, a 63 year old housewife with hyperthyroidism developed a reaction which included fever, pruritus, malaise, and, on one occasion, jaundice one to 17 days after taking carbimazole. Challenge with carbimazole was followed within 12 hours by abdominal pain, pruritus, and increased serum transaminase le...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.11.913
更新日期:1975-11-01 00:00:00
abstract::The lectin, phytohaemagglutinin, present in beans survives passage through the gastrointestinal tract in a biologically and immunologically intact form. It is known that by binding to the brush border membranes of the small intestine phytohaemagglutinin induces its hyperplastic growth. However, its effect on the other...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.3.353
更新日期:1995-09-01 00:00:00
abstract::In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.7.745
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.5.636
更新日期:1997-11-01 00:00:00
abstract::An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.34.5.676
更新日期:1993-05-01 00:00:00
abstract::A method not needing fluoroscopic control for positioning a manometric probe in the gastroduodenal tract is described. It is based on hydrostatic pressure variations occurring at each recording port of a multichannel perfused probe after changes in patient's position. The data are fed into a computer and the schematic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.7.1007
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:In some infants with liver disease, 3-oxo-delta 4 bile acids are the major bile acids in urine, a phenomenon attributed to reduced activity of the delta 4-3-oxosteroid 5 beta-reductase required for synthesis of chenodeoxycholic acid and cholic acid. These patients form a heterogeneous group. Many have a know...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.4.623
更新日期:1996-04-01 00:00:00
abstract::It has been proposed that anti-inflammatory actions of corticosteroids rely on promotion of a natural peptide phospholipase A2 inhibitor, lipocortin, but in vivo effects on arachidonic acid metabolism have not been shown. Equilibrium dialysis of the rectum in patients with ulcerative colitis was used to determine whet...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.9.1095
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2011-301265
更新日期:2013-02-01 00:00:00