Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens.

abstract：:Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver. ...

journal_title：Gut

authors： Lau AH,de Creus A,Lu L,Thomson AW

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Six to 12 months of ingestion of moderate amounts of oats does not have a harmful effect in adult patients with coeliac disease. As the safety of long term intake of oats in coeliac patients is not known, we continued our previous 6-12 month study for five years. AIM:To assess the safety of long term ingest...

journal_title：Gut

authors： Janatuinen EK,Kemppainen TA,Julkunen RJ,Kosma VM,Mäki M,Heikkinen M,Uusitupa MI

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC). DESIGN:We conducted a prospective cohort study of 83 147 participants (age range: 45-79 years) enrolled in the Cohort of Swedish Men and Swedish Mammography Cohort. A validated food...

journal_title：Gut

authors： Khalili H,Håkansson N,Chan SS,Chen Y,Lochhead P,Ludvigsson JF,Chan AT,Hart AR,Olén O,Wolk A

更新日期：2020-09-01 00:00:00

abstract：:Forty six patients with endoscopically diagnosed duodenal ulceration were randomly allocated to treatment with either sucralfate 1 g qds (n = 24) or cimetidine 200 mg tds and 400 mg nocte (n = 22). When the ulcers healed, a maintenance dose of sucralfate 1 g bd or cimetidine 400 mg nocte was given for one year (or unt...

journal_title：Gut

authors： Tovey FI,Husband EM,Yiu YC,Baker L,McPhail G,Lewin MR,Jayaraj AP,Clark CG

更新日期：1989-05-01 00:00:00

abstract：:It has been suggested, on the basis of impaired granulocyte migration to skin windows, that there is a fundamental granulocyte defect in Crohn's disease. In vitro tests of granulocyte function have, however, failed to confirm this. We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new ...

journal_title：Gut

authors： Saverymuttu SH,Peters AM,Lavender JP,Chadwick VS,Hodgson HJ

更新日期：1985-04-01 00:00:00

abstract：:The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...

journal_title：Gut

authors： al Mardini H,al Jumaili B,Record CO,Burke D

更新日期：1991-09-01 00:00:00

abstract：:Endoscopic sphincterotomy was undertaken in 186 patients with common bile duct stones and an intact gall bladder who were considered unfit for surgery. One hundred and seventy one patients had jaundice of whom 18 also had clinical cholangitis. The mean age of treated patients was 79.7 years (range 27-92) and only 13 w...

journal_title：Gut

authors： Ingoldby CJ,el-Saadi J,Hall RI,Denyer ME

更新日期：1989-08-01 00:00:00

abstract：:An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin. Secretin resulted in the production of a large volume of low viscous pancreatic juice and was associated with an increase in the cardia...

journal_title：Gut

authors： Goodhead B,Himal HS,Zanbilowicz J

更新日期：1970-01-01 00:00:00

abstract：:Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute ...

journal_title：Gut

authors： Hobsley M,Silen W

更新日期：1969-10-01 00:00:00

abstract：:Five patients in whom small-intestinal bypass was performed for severe obesity had a second operation 11-19 months later because of insufficient weight loss. Mucosal enzyme activities and histological appearance were investigated in biopsies from different parts of the functioning and excluded small intestine. These w...

journal_title：Gut

authors： Asp NG,Gudmand-Høyer E,Andersen B,Berg NO

更新日期：1979-07-01 00:00:00

abstract：:In 1964 Samman and White described 13 patients with lymphoedema of the lower extremities associated with an unusual dystrophy of the finger and toe nails: this they termed the 'yellow-nail' syndrome. Affected nails were thickened, excessively curved along both axes, very slow growing and of yellowish-grey hue; cuticle...

journal_title：Gut

authors： Duhra PM,Quigley EM,Marsh MN

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocyti...

journal_title：Gut

authors： Uza N,Nakase H,Yamamoto S,Yoshino T,Takeda Y,Ueno S,Inoue S,Mikami S,Matsuura M,Shimaoka T,Kume N,Minami M,Yonehara S,Ikeuchi H,Chiba T

更新日期：2011-11-01 00:00:00

abstract：:Early carcinoma of the gastric remnant was diagnosed in 19 patients between January 1976 and January 1986. In all patients early cancer was suspected at endoscopy and confirmed by biopsy and histology. The main reason for endoscopic examination was diffuse epigastric pain suggestive of stump gastritis. The surgical pr...

journal_title：Gut

authors： Pointner R,Schwab G,Königsrainer A,Bodner E,Schmid KW

更新日期：1988-03-01 00:00:00

abstract：:Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activ...

journal_title：Gut

authors： Henman FD

更新日期：1970-04-01 00:00:00

abstract：:Clinically significant liver involvement in systemic amyloidosis, especially with cholestasis, is rare. We report a case of primary amyloidosis with severe intrahepatic cholestasis leading to terminal liver failure. The present case is the first of its kind reported involving Lambda light chains only as the associated...

journal_title：Gut

authors： Konikoff F,Mor C,Stern S,Shaklai M,Halevy J,Theodor E

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer (CRC) incidence is higher in African Americans (AAs) compared with non-Hispanic whites (NHWs). A diet high in animal protein and fat is an environmental risk factor for CRC development. The intestinal microbiota is postulated to modulate the effects of diet in promoting or preventing CRC. Hy...

journal_title：Gut

authors： Yazici C,Wolf PG,Kim H,Cross TL,Vermillion K,Carroll T,Augustus GJ,Mutlu E,Tussing-Humphreys L,Braunschweig C,Xicola RM,Jung B,Llor X,Ellis NA,Gaskins HR

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects. AIMS:The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supple...

journal_title：Gut

authors： Cragg RA,Phillips SR,Piper JM,Varma JS,Campbell FC,Mathers JC,Ford D

更新日期：2005-04-01 00:00:00

abstract：:The aim of this study was to develop and validate an endoscopic index for assessing the severity of Crohn's disease. Endoscopic findings were prospectively collected by a multicentre group in 75 patients with Crohn's colitis according to a previously validated procedure. The presence of nine preselected lesions was re...

journal_title：Gut

authors： Mary JY,Modigliani R

更新日期：1989-07-01 00:00:00

abstract：:Multiple endoscopic specimens were obtained from 58 patients with a columnar lined gesophagus to study the histological and histochemical features of this metaplastic epithelium. Five patients (8.6%) had presented with a primary oesophageal adenocarcinoma. Three different epithelial types, junctional, atrophic fundic ...

journal_title：Gut

authors： Rothery GA,Patterson JE,Stoddard CJ,Day DW

更新日期：1986-09-01 00:00:00

abstract：:This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...

journal_title：Gut

authors： GOULSTON SJ,GALLAGHER ND

更新日期：1962-09-01 00:00:00

abstract：:The plasma clearance and the liver uptake of intravenously administered (64)Cu were significantly impaired in four patients with Wilson's disease. These defects were unlikely to be simply expressions of the high liver copper concentration as the plasma clearance and hepatic uptake of (64)Cu were normal in four patient...

journal_title：Gut

authors： Smallwood RA,McIlveen B,Rosenoer VM,Sherlock S

更新日期：1971-02-01 00:00:00

abstract：:In order to investigate further the reported beneficial effect of deglycyrrhizinated liquorice in gastric ulcer, a trial with a double-blind, cross-over design was performed. The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo du...

journal_title：Gut

authors： Engqvist A,von Feilitzen F,Pyk E,Reichard H

更新日期：1973-09-01 00:00:00

abstract：:Increased antibody production and hypergammaglobulinaemia in cirrhosis are probably to a large extent due to decreased hepatic extraction of antigens. The deceased extraction is presumably related to changed microcirculation caused by damaged anatomical structure of the liver. It is therefore to be expected that immun...

journal_title：Gut

authors： Prytz H,Bjorneboe M,Christoffersen P,Poulsen H,Orskov F

更新日期：1977-01-01 00:00:00

abstract：AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...

journal_title：Gut

authors： Lewison G

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Shanghai fever, a community-acquired enteric illness associated with sepsis caused by Pseudomonas aeruginosa, was first described in 1918. The understanding of Shanghai fever is incomplete. OBJECTIVE:To delineate the clinical features and to examine the host and microbial factors associated with Shanghai fe...

journal_title：Gut

authors： Chuang CH,Wang YH,Chang HJ,Chen HL,Huang YC,Lin TY,Ozer EA,Allen JP,Hauser AR,Chiu CH

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Obstructive jaundice is associated with postoperative complications related to increased endotoxaemia and the inflammatory response. In animals obstructive jaundice is associated with endotoxaemia and cytokine induction, which are reversed by internal biliary drainage. AIMS:To study endotoxaemia and the sub...

journal_title：Gut

authors： Kimmings AN,van Deventer SJ,Obertop H,Rauws EA,Huibregtse K,Gouma DJ

更新日期：2000-05-01 00:00:00

abstract：:In dogs with either vagally innervated or denervated pouches, the acid responses to a standard meal, a meal which bypassed the greater part of the small bowel, and a meal introduced directly into the small intestine were measured before and after exclusion of 75% of the small bowel.After intestinal exclusion an increa...

journal_title：Gut

authors： Buxton B,Wasunna AE,Saunders J,Gillespie IE

更新日期：1972-07-01 00:00:00

abstract：:The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.2...

journal_title：Gut

authors： Raimundo AH,Patil DH,Frost PG,Silk DB

更新日期：1991-03-01 00:00:00

abstract：:Little is known about chronic constipation in infants, toddlers, and preschool children and longterm outcome after treatment. The symptoms of 174 children < or = 4 years of age, who were evaluated for chronic constipation, are reported in this study together with the long-term outcome in 90 of them. Initial symptoms w...

journal_title：Gut

authors： Loening-Baucke V

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Chronic idiopathic intestinal pseudo-obstruction (CIIP) is characterised by severe impairment of intestinal propulsive motility that mimics bowel obstruction. JC virus (JCV) is a polyomavirus that can infect brain glial cells causing a fatal disease, but may also be found throughout the normal gastr...

journal_title：Gut

authors： Selgrad M,De Giorgio R,Fini L,Cogliandro RF,Williams S,Stanghellini V,Barbara G,Tonini M,Corinaldesi R,Genta RM,Domiati-Saad R,Meyer R,Goel A,Boland CR,Ricciardiello L

更新日期：2009-01-01 00:00:00